Results 91 to 100 of about 1,376,553 (308)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Use of Low Molecular Weight Antigens of Mycobacterium tuberculosis as a New Skin Test for Specific Diagnosis of Tuberculosis

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2019
Background and Objectives: Tuberculosis (TB) is an infectious disease and about one-third of the world population are infected with latent TB infection.
Davoud Sadeghi Gariz, Nader Mosavari
doaj  

Unexpected anaphylaxis to tranexamic acid confirmed by drug provocation testing in orthopedic surgery: A case report

Saudi Journal of Anaesthesia
Tranexamic acid (TXA) is commonly used in orthopedic surgery to reduce perioperative bleeding. Although generally safe, TXA has been associated with rare, but potentially life-threatening anaphylactic reactions.
Seung Eun Song, Ae-Ryoung Lee
doaj   +1 more source

Multicenter assessment of quantitative sensory testing (QST) for the detection of neuropathic-like pain responses using the topical capsaicin model [PDF]

, 2018
Background: The use of quantitative sensory testing (QST) in multicenter studies has been quite limited, due in part to lack of standardized procedures among centers. Aim: The aim of this study was to assess the application of the capsaicin pain model
Bushnell, M. Catherine, Chouchou, Florian, Ferland, Catherine E., Gandhi, Wiebke, Jackson, Philip L., Lavigne, Gilles, Ma, My-Linh, Marchand, Serge, Michon, Pierre-Emmanuel, Parent, Alexandre J., Rainville, Pierre, Schweinhardt, Petra, Villemure, Chantal, Ware, Mark A.   +13 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Performance of a Haynes 188 metallic standoff thermal protection system at Mach 7 [PDF]

A flight weight, metallic thermal protection system (TPS) model applicable to reentry and hypersonic vehicles was subjected to multiple cycles of both radiant and aerothermal heating to evaluate its aerothermal performance and structural integrity.
Avery, D. E.
core   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Corrosion Behavior of Parylene-Metal-Parylene Thin Films in Saline [PDF]

, 2008
In this paper, we study the corrosion behavior of parylene-metal-parylene thin films using accelerated-lifetime soak tests. The samples under test are thin film resistors with a 200 nm layer of Au sandwiched by parylene-C on both sides, fabricated with ...
Li, W., Menon, P. R., Rodger, D. C., Tai, Y. C.   +3 more
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

The Pattern of Sensitisation to Inhalant Allergens in Omani Patients with Asthma, Allergic Rhinitis and Rhinoconjunctivitis

Sultan Qaboos University Medical Journal, 2008
Objective: Identification of relevant allergens that are prevalent in each environment which may have diagnostic and therapeutic implications in allergic diseases.
Salem H Al-Tamemi, Azza N Al-Shidhani, Rashid K Al-Abri, Balaji Jothi, Omar A Al-Rawas, Bazdawi M Al-Riyami   +5 more
doaj