Results 71 to 80 of about 17,654,957 (400)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Identifying and treating mycotic skin infections

, 2003
To provide physicians and nurses with an overview of mycotic infections and related cutaneous manifestations. This continuing-education activity is intended for physicians and nurses with an interest in learning how to recognize and treat mycotic skin ...
Trent, Jennifer T, Kirsner, Robert S
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Skin Testing with Inhaled Allergens: A Family Physician's Experience

South African Family Practice, 1990
No abstract available.
R.J.E. Erasmus
doaj   +1 more source

Eczema phenotypes and risk of allergic and respiratory conditions in school age children

Clinical and Translational Allergy, 2020
Background Eczema phenotypes based on eczema onset and persistence might better identify groups prone to allergic and respiratory conditions than a binary definition of eczema.
Chen Hu, Tamar Nijsten, Evelien R. van Meel, Nicole S. Erler, Christophe Piketty, Nicolette W. de Jong, Suzanne G. M. A. Pasmans, Johan C. de Jongste, Liesbeth Duijts   +8 more
doaj   +1 more source

Evaluation of skin test indications for general anesthetics in real life: a prospective cohort study

Brazilian Journal of Anesthesiology, 2022
Background: In daily practice, atopic patients and those who have other drug allergies are referred to allergy clinics for evaluation of possible general anesthetic allergy despite the fact that it is not recommended in recent guidelines.
Sengul Beyaz, Raif Coskun, Nida Oztop, Evren Aygun, Mukadder Orhan Sungur, Tulay Ozkan Seyhan, Semra Demir, Muge Olgac, Derya Unal, Bahauddin Colakoglu, Suna Buyukozturk, Asli Gelincik   +11 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The Role of Medical History and Allergic Tests in the Analysis of Antibiotic Allergy in the Pediatric Population

Allergies
According to parental reports, about 10% of children are believed to be allergic to at least one antibiotic, leading to the prescription of second line medications. This incurs higher costs, results in less effective treatments, and contributes to global
Margarita Dimitroglou, Dafni Moriki, Olympia Sardeli, Elpiniki Kartsiouni, Despoina Koumpagioti, Angeliki Galani, Vassiliki Papaevangelou, Konstantinos Douros   +7 more
doaj   +1 more source

Application of modern immunological methods in the diagnosis of tuberculosis in HIV-infected patients

Журнал инфектологии, 2015
Combination of TB and HIV-infection is still the most nowadays important problem, and it connects not only with steady growth of HIV infection, but with difficulties in TB diagnosis.
A. A. Starshinova, A. M. Panteleev, E. V. Vasil’eva, V. V. Manina, M. V. Pavlova, N. V. Sapozhnikova   +5 more
doaj   +1 more source