Results 61 to 70 of about 1,376,553 (308)

Allergy Profile of Patients Visiting a Tertiary Care Hospital in Hilly Areas of Solan, Himachal Pradesh, India [PDF]

Journal of Clinical and Diagnostic Research, 2018
Introduction: Allergic diseases are common and affect a large population worldwide. Not many studies are available regarding the same and almost none in Solan district.
Manpreet Singh Nanda, Kamaljit Singh, Rama Devi   +2 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Stability of diluted chlorhexidine for skin testing in drug allergy evaluations

Journal of Allergy and Clinical Immunology: Global
Background: Chlorhexidine gluconate (CHX), a common cause of perioperative anaphylaxis, is frequently used for skin testing in allergy evaluations. Although CHX’s maximal nonirritating concentrations are known, the stability of its dilutions for skin ...
Divya Shah, MD, Gabriel Cojuc-Konigsberg, BS, Stacy D. Brown, PhD, Sergio E. Chiarella, MD, Gerald W. Volcheck, MD, Hirohito Kita, MD, Lene H. Garvey, MD, PhD, Alexei Gonzalez-Estrada, MD   +7 more
doaj   +1 more source

Effect of a Clinical Evidence Technology on Patient Skin Disease Outcomes in Primary Care: A Cluster-Randomized Controlled Trial [PDF]

, 2018
Objective: Providers’ use of clinical evidence technologies (CETs) improves their diagnosis and treatment decisions. Despite these benefits, few studies have evaluated the impact of CETs on patient outcomes. Investigators evaluated the effect of one CET,
Burke, Marianne, Littenberg, Benjamin, MD   +1 more
core   +1 more source

Immediate-Type Hypersensitivity to Succinylated Corticosteroids [PDF]

, 2011
Background: Despite their frequent use, systemic corticosteroids have rarely elicited immediate-type reactions. Objective: We report two male patients, aged 26 and 70 years, respectively, with severe immediate-type hypersensitivity secondary to the ...
Przybilla, Bernhard, Raewer, Helen-Caroline, Sieber, Wolfgang, Walker, Annett Isabel   +3 more
core   +1 more source

Horse-serum skin tests [PDF]

Journal of Hygiene, 1938
An investigation is described which shows the type of skin reaction which may be expected from the intracutaneous injection of 0·1 c.c. normal horse serum in the normal and sensitized human subject. 150 normal individuals and 100 who had received previous serum injection were skin-tested. Of the normal subjects 30% showed a reaction of skin sensitivity,
openaire   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Assessment of patch test results carried out during ten years in a city in southern Brazil [PDF]

Anais Brasileiros de Dermatologia, 2018
: Background: Contact dermatitis affects up to 20% of the population. Patch testing for contact allergy may be needed to confirm the diagnosis. Objectives: To describe and discuss the results of patch tests performed in a city in southern Brazil ...
Mariane Corrêa-Fissmer, Cintia Camila Dalazen, Bárbara Piacentini Ferreira, Betine Pinto Moehlecke Iser   +3 more
doaj   +1 more source

Innovative Agents for Actinic Keratosis and Nanocarriers Enhancing Skin Penetration [PDF]

, 2010
Actinic keratosis and cutaneous squamous cell carcinoma are of increasing importance with aging and increased ultraviolet light exposure in Western societies. Efficient and well-tolerated therapy is still a matter of concern.
Höltje, H.-D., Höltje, M., Korting, Hans Christian, Schäfer-Korting, Monika   +3 more
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source