Results 91 to 100 of about 4,746,716 (297)

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

3D Bioprinted Blood–Brain–Tumor Barrier Spheroid‐Based In Situ Evaluation of Anticancer Compounds Against Glioblastoma: ROS‐Producing Ruthenium as a Potential Therapeutic Candidate

Advanced Science, EarlyView.
The blood–brain–tumor barrier (BBTB) penetration by anticancer drugs and their effects on glioblastoma (GBM) is assessed using 3D bioprinted‐spheroids. Anticancer drug‐induced U‐87 MG cell death is quantified through in situ imaging of spheroids using a cancer cell death probe. The Ru compound, a partial P‐gp substrate, induces greater tumor‐cell death
Hyunjung Lee, Chan Ho Jeon, Doyun Kim, Minjae Lee, Minji Kwon, Joon Myong Song   +5 more
wiley   +1 more source

Parotid and Temporal Bone Resection for Skull Base Malignancies: Outcome

, 2010
We reviewed the outcome of and determined prognostic factors for patients undergoing combined lateral skull base resection for advanced lateral skull base malignancies.
Arnold, David, Angeli, Simon, Sargi, Zoukaa, Telischi, Fred, Weed, Donald, Civantos, Francisco, Gerring, Robert, Eshraghi, Adrien   +7 more
core   +1 more source

Age‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission

Advanced Science, EarlyView.
This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie   +12 more
wiley   +1 more source

Selective reconstructive options for the anterior skull base

, 2005
Carcinomas of the ethmoid, frontal, or maxillary sinuses sometimes invade the anterior skull base. It is necessary to perform en-bloc resection for this invasive carcinoma according to the concepts of surgical treatment for head and neck cancer.
KATO, Takashi, NAMEKI, Hideo, NAMEKI, Ichirota   +2 more
core  

Meningeal Lymphatic LTBR Deficiency Links Spinal Cord Injury to Secondary Brain Pathology

Advanced Science, EarlyView.
Spinal cord injury (SCI) induces remote brain alterations beyond the injured spinal cord. This study links dysfunction of meningeal lymphatic vessels (mLVs) to neuroinflammation and neuronal injury after SCI. LTBR‐mediated lymphatic restoration improves meningeal lymphatic integrity and neurological outcomes, highlighting LTBR as a potential regulator ...
Yi Chen, Yu Tang, Chengpeng Hu, Xiaoyan Duan, LingXia Min, Boya Cong, Chao Ma, Mingliang Tan, Ya Luo, Pengfei Wei, Minpeng Xu, Zhou Feng, Jingming Hou   +12 more
wiley   +1 more source

Management Strategies for Communited Fractures of Frontal Skull Base: An Institutional Experience

Indian Journal of Neurosurgery, 2015
Aim The aim of this study is to present our experience in management of complex, communited fractures of the frontal skull base. Patients and Methods This was a retrospective study performed between January 2000 to January 2013.
V. Velho, Hrushikesh U. Kharosekar, Jasmeet S. Thukral, Shonali Valsangkar, P. Survashe   +4 more
doaj   +1 more source

Coronoid-Temporalis Pedicled Rotation Flap for Middle Skull Base Reconstruction

, 2013
We report on a patient who underwent maxillectomy and subsequent coronoid-temporalis flap reconstruction of the surgical defect to treat a maxillary sinus carcinoma invading the middle skull base.
IŞIK, ABDÜLCEMAL ÜMİT, KOŞUCU, POLAT, Cansiz, Harun, Arslan, Selcuk, Arslan, Erhan   +4 more
core   +1 more source

Mac‐2 Binding Protein Glycosylation Isomer (M2BPGi)–Based Risk Stratification Refined by Tumor Metabolic Activity in Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
M2BPGi reflects background liver fibrosis and hepatic functional impairment. PET SUVmax reflects tumor metabolic aggressiveness. Their combination identifies a dual‐high subgroup with the poorest recurrence‐free and overall survival. ABSTRACT Aim To evaluate the prognostic significance of preoperative Mac‐2 binding protein glycosylation isomer (M2BPGi)
Kojiro Shirabe, Junya Mita, Shinji Itoh, Takeo Toshima, Yoshiyuki Kitamura, Norifumi Iseda, Takuro Isoda, Kousei Ishigami, Tomoharu Yoshizumi   +8 more
wiley   +1 more source

Single-Stage Rigid Midfacial Reconstruction Using Split Calvarial Bone after Anterior Skull Base Surgery: A Case Report

Journal of Plastic and Reconstructive Surgery
Reports of frontal and nasal bone-involving composite midfacial bone defect reconstruction after anterior skull base tumor resection remain scarce.
Naoya Ishida, Kentaro Tanaka, Yosuke Ariizumi, Yoshihisa Kawano, Rie Kayashima, Kyoichi Murakami, Mayu Ueno   +6 more
doaj