Results 41 to 50 of about 88,174 (264)

Simultaneous reconstruction of evolutionary history and epidemiological dynamics from viral sequences with the birth-death SIR model

, 2014
The evolution of RNA viruses such as HIV, Hepatitis C and Influenza virus occurs so rapidly that the viruses' genomes contain information on past ecological dynamics.
Drummond, Alexei J., Kühnert, Denise, Stadler, Tanja, Vaughan, Timothy G.   +3 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Horseshoe-based Bayesian nonparametric estimation of effective population size trajectories

, 2019
Phylodynamics is an area of population genetics that uses genetic sequence data to estimate past population dynamics. Modern state-of-the-art Bayesian nonparametric methods for recovering population size trajectories of unknown form use either change ...
Carpenter B., Easton N.A., Felsenstein J., Holmes C.E., Murray I., Neal R., Palacios J.A., R Core Team, Watanabe S.   +8 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Метод та програмний засіб формування Skyline-вибірок з багатовимірних даних

Adaptivni Sistemi Avtomatičnogo Upravlinnâ
Метою даної роботи є вирішення проблем CoD та високої складності інтеграції існуючих рішень для формування Парето-фронтів шляхом розробки та впровадження методу та спеціалізованого програмного засобу формування Skyline-вибірок.
В. Кривоносюк, І. Стеценко   +1 more
doaj   +1 more source

Scene-Awareness Based Single Image Dehazing Technique via Automatic Estimation of Sky Area

IEEE Access, 2019
The occurrence of fog, mist, smog, or haze significantly reduces the visibility of the scenes and images, resulting in limited recognition of computer vision and computer graphics. So, removing haze from images is a must.
Hui Fu, Bin Wu, Yanhua Shao, Hongying Zhang   +3 more
doaj   +1 more source

New hyper-Kaehler manifolds by fixing monopoles

, 1997
The construction of new hyper-Kaehler manifolds by taking the infinite monopole mass limit of certain Bogomol'nyi-Prasad-Sommerfield monopole moduli spaces is considered.
A. S. Dancer, A. S. Dancer, A. S. Dancer, C. J. Houghton, Conor J. Houghton, E. J. Weinberg, G. W. Gibbons, G. W. Gibbons, J. Hurtubise, J. P. Gauntlett, K. Lee, K. Lee, M. F. Atiyah, N. J. Hitchin, N. J. Hitchin, N. S. Manton, R. Bielawski, S. W. Hawking, W. Nahm   +18 more
core   +2 more sources

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

A tale of (at least) two cities [PDF]

, 2008
Modernism is built on a foundation of the double, the facsimile and similitude – the repetitions of the machine age. Model T-Fords, Motel chains and Fast Food restaurants are the most obvious – most digestible? – remnants of the modernist production line.
Davies, Colin, Parrinder, Monika
core