Results 51 to 60 of about 92,772 (328)

I/O-Efficient Dynamic Planar Range Skyline Queries [PDF]

, 2012
We present the first fully dynamic worst case I/O-efficient data structures that support planar orthogonal \textit{3-sided range skyline reporting queries} in $\bigO (\log_{2B^\epsilon} n + \frac{t}{B^{1-\epsilon}})$ I/Os and updates in $\bigO (\log_{2B^\
Kejlberg-Rasmussen, Casper, Tsakalidis, Konstantinos, Tsichlas, Kostas   +2 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Balloon logging with the inverted skyline [PDF]

, 1975
There is a gap in aerial logging techniques that has to be filled. The need for a simple, safe, sizeable system has to be developed before aerial logging will become effective and accepted in the logging industry.
Mosher, C. F.
core   +1 more source

Simultaneous reconstruction of evolutionary history and epidemiological dynamics from viral sequences with the birth-death SIR model

, 2014
The evolution of RNA viruses such as HIV, Hepatitis C and Influenza virus occurs so rapidly that the viruses' genomes contain information on past ecological dynamics.
Drummond, Alexei J., Kühnert, Denise, Stadler, Tanja, Vaughan, Timothy G.   +3 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The multifurcating skyline plot [PDF]

Virus Evolution, 2018
Abstract A variety of methods based on coalescent theory have been developed to infer demographic history from gene sequences sampled from natural populations. The ‘skyline plot’ and related approaches are commonly employed as flexible prior distributions for phylogenetic trees in the Bayesian analysis of pathogen gene sequences.
Hoscheit, Patrick, Pybus, Oliver G.
openaire   +6 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Feedback-Driven Pattern Matching in Time Series Data

IEEE Access
While motif discovery methods have come a long way over the years, they generally match occurrences based on the similar shape of the whole subsequence.
M. Van Onsem, V. Ledoux, W. Melange, D. Dreesen, S. Van Hoecke   +4 more
doaj   +1 more source

A Skyline-Based Decision Boundary Estimation Method for Binominal Classification in Big Data

Computation, 2020
One of the most common tasks nowadays in big data environments is the need to classify large amounts of data. There are numerous classification models designed to perform best in different environments and datasets, each with its advantages and ...
Christos Kalyvas, Manolis Maragoudakis
doaj   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source