Results 41 to 50 of about 14,247 (264)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Probabilistic contextual skylines [PDF]
2010 IEEE 26th International Conference on Data Engineering (ICDE 2010), 2010 The skyline query returns the most interesting tuples according to a set of explicitly defined preferences among attribute values. This work relaxes this requirement, and allows users to pose meaningful skyline queries without stating their choices. To compensate for missing knowledge, we first determine a set of uncertain preferences based on user ...
Dimitris Sacharidis +2 more
openaire +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Skyline Path Queries With Aggregate Attributes
IEEE Access, 2016 The skyline path query is a novel extension of skyline queries. A skyline path query retrieves a set of non-dominated paths from origin s to destination t.
Yi-Chung Chen, Chiang Lee
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Optimization of Quantitative Evaluation Method for Urban Waterfront Building Cluster Skyline
BuildingsIn the contemporary era, where digital audio-visual media continues to evolve, the media landscape is increasingly converging with the urban landscape. This trend has made the importance of urban waterfront areas in city landscapes more pronounced.
Jian Zhang, Wenlei Luan, Jieshuai Zhang
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Optimizing Skyline Query Processing in Incomplete Data
IEEE Access, 2019 Given the significance of skyline queries, they are incorporated in various modern applications including personalized recommendation systems as well as decision-making and decision-support systems.
Yonis Gulzar +2 more
doaj +1 more source