Results 51 to 60 of about 125,426 (247)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
New Associated Curves k-Principle Direction Curves and N_k Slant Helix
, 2014 The Frenet frame is generally known an orthonormal vector frame for curves. But, it does not always meet the needs of curve characterizations. In this study, with the help of associated curves of any spatial curve we obtained a new orthonormal frame which has the property that the second vector makes a constant angle with a fixed direction for the ...
RAMİS, Çağla +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
$V_{n}$-slant helices in Euclidean $n$-space $E^{n}$ [PDF]
, 2009 In this paper, we give a definition of harmonic curvature functions in terms of $V_{n}$ and we define a new kind of a slant helix. We call this new slant helix a $V_{n}$-slant helix in $n$-dimensional Euclidean space $E^{n}$ and define it by using new ...
Gök, İsmail +2 more
core +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Helix Notice of Adopted Amendment (2010-08-27)
, 2010 15 pp. Adopted 2010-08-27. Department of Land Conservation and Development Notice of Adopted AmendmentAs required by Federal Emergency Management Agency, the city of Helix updated its floodplain ordinance and adopted new digital floodplain maps in order ...
Helix
core +1 more source
New Frameworks for Constructing Special Curves via f-Weighted Direction Curves
MathematicsIn this paper, we investigate three classes of f-weighted direction curves, namely tangent, principal, and binormal direction curves, obtained by integrating positive smooth multiples of the corresponding Frenet vector fields of a generating Frenet curve
Levent Kula
doaj +1 more source
Frenet Curves and Successor Curves: Generic Parametrizations of the Helix and Slant Helix
, 2013 In classical curve theory, the geometry of a curve in three dimensions is essentially characterized by their invariants, curvature and torsion. When they are given, the problem of finding a corresponding curve is known as 'solving natural equations'. Explicit solutions are known only for a handful of curve classes, including notably the plane curves ...
openaire +2 more sources
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Ruled Surfaces with Bishop vectors via Smarandache geometry
MANAS: Journal of EngineeringThe paper studies new ruled surfaces with the vectors of Bishop frame via Smarandache geometry. The fundamental forms and the corresponding curvatures are provided for each ruled surface to draw characteristics of the surfaces such as developability and ...
Kebire Hilal Ayvacı Şimşek +2 more
doaj +1 more source