Results 61 to 70 of about 2,699,597 (146)

TRPC4 Mediates Trigeminal Neuropathic Pain via Ca2+‐ERK/P38‐ATF2 Pathway in the Trigeminal Ganglion of Mice

CNS Neuroscience &Therapeutics, Volume 31, Issue 4, April 2025.
The specific mechanism of trigeminal neuropathic pain (TNP) is not fully understood. Through the chronic constriction of the unilateral infraobital nerve (CION) mouse model, we found that nerve compression injury leads to increased expression levels of TRPC4, a sensory neuron in the trigeminal ganglion.
Xinlong Ke, Huajing Cai, Fangla Luo, Xing Zheng, Qian Hu, Youfa Zhou, Yongjie Wang, Xiangnan Zhang, Yeru Chen, Gang Chen   +9 more
wiley   +1 more source

METTL16 is Required for Meiotic Sex Chromosome Inactivation and DSB Formation and Recombination during Male Meiosis

Advanced Science, Volume 12, Issue 3, January 20, 2025.
METTL16 predominantly controls the expression of critical meiotic genes essential for DSB formation and recombination in early meiotic spermatocytes and is involved in the expansion of DNA damage response (DDR) factors and epigenetic modifications in the XY body for the establishment and maintenance of meiotic sex chromosome inactivation (MSCI) in ...
Lisha Yin, Nan Jiang, Wenjing Xiong, Shiyu Yang, Jin Zhang, Mengneng Xiong, Kuan Liu, Yuting Zhang, Xinxin Xiong, Yiqian Gui, Huihui Gao, Tao Li, Yi Li, Xiaoli Wang, Youzhi Zhang, Fengli Wang, Shuiqiao Yuan   +16 more
wiley   +1 more source

Effect of chronic exposure of pancreatic acinar 266-6 cells to NNK on activity of SLC19A2 and SLC19A3 promoters.

, 2013
Full-length SLC19A2 (A) and SLC19A3 (B) promoters in pGL3-Basic were transfected into 266-6 cells were exposed to 3 µM NNK for 24 h followed by determination of luciferase activity.
Veedamali S. Subramanian (452244), Padmanabhan Srinivasan (481324), Hamid M. Said (385809)   +2 more
core   +1 more source

Neonatal diabetes mellitus around the world: Update 2024

Journal of Diabetes Investigation, Volume 15, Issue 12, Page 1711-1724, December 2024.
Between 2018 and early 2024, six brand new NDM‐genes have been discovered and 3 genes known to cause different diseases were identified as NDM‐genes. Currently NDM genes' list exceeds forty.This genetic heterogeneity translates into many different mechanism(s) of disease that are investigated with state‐of‐the‐art methodologies, such as induced ...
Fabrizio Barbetti, Asma Deeb, Shigeru Suzuki   +2 more
wiley   +1 more source

Dietary thiamine influences L-asparaginase sensitivity in a subset of leukemia cells

, 2020
Tumor environment influences anticancer therapy response but which extracellular nutrients affect drug sensitivity is largely unknown. Using functional genomics, we determine modifiers of l-asparaginase (ASNase) response and identify thiamine ...
Williams, Robert T., Birsoy, Kivanc, Mestanoglu, Mert, Guarecuco, Rohiverth, La, Konnor, Passarelli, Maria C., Molina, Henrik, Baudrier, Lou, Alwaseem, Hanan, Fidelin, Justine, Ekizoglu, Naz, Garcia-Bermudez, Javier, Rostandy, Bety, La, Konnor C.   +13 more
core   +1 more source

Ectoin attenuates cortisone‐induced skin issues by suppression GR signaling and the UVB‐induced overexpression of 11β‐HSD1

Journal of Cosmetic Dermatology, Volume 23, Issue 12, Page 4303-4314, December 2024.
Abstract Background Accelerated pace of modern work and lifestyles subject individuals to various external and psychological stressors, which, in turn, can trigger additional stress through visible signs of fatigue, hair loss, and obesity. As the primary stress hormone affecting skin health, cortisol connects to the glucocorticoid receptor (GR) to ...
Dailin Xu, Yue Wu
wiley   +1 more source

Recurrent Stroke in a Child with TRMA Syndrome and SLC19A2 Gene Mutation.

Iranian journal of child neurology
Here we report a 5-month-old boy with thiamine Responsive Megaloblastic Anemia syndrome (TRMA syndrome) with several attacks of stroke, admitted to Mofid Children's Hospital, Tehran, Iran, in 2016. In addition to the cardinal clinical manifestations of the syndrome, other manifestations comprise thiamine-responsive megaloblastic anemia, diabetes ...
Parvaneh, Karimzadeh, Toktam, Moosavian, Hamidreza, Moosavian   +2 more
openaire   +1 more source

Effect of chronic exposure of transgenic mice carrying SLC19A2 and SLC19A3 promoters to NNK on the activity of these promoters.

, 2013
The activity of SLC19A2 (A) and SLC19A3 (B) promoters were determined as described in “Materials and Methods” and are presented as percentage relative to pair-fed controls.
Veedamali S. Subramanian (452244), Padmanabhan Srinivasan (481324), Hamid M. Said (385809)   +2 more
core   +1 more source

Association of the CCR5 gene with juvenile idiopathic arthritis [PDF]

, 2010
The CC chemokine receptor 5 (CCR5) has been shown to be important in the recruitment of T-helper cells to the synovium, where they accumulate, drive the inflammatory process and the consequent synovitis and joint destruction.
Martin, P., BSPAR Study Group, Barton, A., UKRAG Consortium, Worthington, J., Gardner-Medwin, J. [CAPS and BSPAR Study Groups], Thomson, W., W Thomson, Flynn, E., A Hinks, E Flynn, J Packham, Packham, J., Hinks, A., S Eyre, J Worthington, Eyre, S.; id_orcid, Eyre, S., Barton, A.; id_orcid, P Martin, Childhood Arthritis Prospective Study (CAPS), Martin, P.; id_orcid, A Barton   +22 more
core   +1 more source

Role of the minimal regions of the SLC19A2 and SLC19A3 promoters in mediating the NNK effect.

, 2013
Full-length and minimal SLC19A2 (A) and SLC19A3 (B) promoters in pGL3-Basic were transiently transfected in 266-6 pancreatic acinar cells; luciferase assays were performed as described under “Materials and Methods”.
Veedamali S. Subramanian (452244), Padmanabhan Srinivasan (481324), Hamid M. Said (385809)   +2 more
core   +1 more source