Results 61 to 70 of about 1,678 (140)

Amino Acid and Lipid Metabolism in Cancer: Mechanisms and Therapeutic Opportunities

MedComm, Volume 7, Issue 8, August 2026.
Amino Acid and lipid metabolism in cancer: (A) Regulation of Amino acid transportation and metabolism in cancer. (B) The core organization of lipid metabolic reprogramming in cancer and their functional consequences. ABSTRACT Metabolic reprogramming is a defining feature of cancer and a major contributor to immune escape.
Zixu Wang, Xin Fu, Jingchao Bai, Yanguo Liu, Kai Huang   +4 more
wiley   +1 more source

The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes

The FEBS Journal, Volume 293, Issue 15, Page 4489-4507, August 2026.
Brown fat cells burn lipids within their mitochondria to generate heat. This process involves two energy “shuttles,” one of which is naturally blocked during heat production. We found that the second shuttle (MASh) is not required to generate heat. However, when MASh is disabled, the fatty acids meant for fuel are instead converted back into stored fat.
Michaela Veliova, Caroline M. Ferreira, Katrina P. Montales, Francisco Villalobos, Alexandra J. Brownstein, Rebeca Acín‐Pérez, Gabrielly S. Ferreira, Anthony E. Jones, Linsey Stiles, Ajit S. Divakaruni, Marc Liesa, Orian S. Shirihai, Marcus F. Oliveira   +12 more
wiley   +1 more source

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, Volume 600, Issue 12, Page 1770-1781, June 2026.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

The impact of FMDV infection on the expression of amino acid transporter.

, 2023
PK-15 cells were infected with FMDV (MOI 0.5) for 0, 4, 8, and 12 h. The cells were collected to extract mRNA. The mRNA levels of SLC1A1, SLC1A2, SLC1A3, SLC1A6, SLC1A7, SLC25A12, SLC25A13, and SLC38A7 were determined by qPCR. n = 3.
Weijun Cao (122575), Haixue Zheng (286790), Zixiang Zhu (280085), Huisheng Liu (408091), Fan Yang (1413), Xiangtao Liu (286800), Qiao Xue (431091), Zhaoning Xue (14564656)   +7 more
core   +1 more source

Plasmacytoid Dendritic Cells Exhibit High Transferrin Receptor Expression Without Iron Accumulation

European Journal of Immunology, Volume 56, Issue 6, June 2026.
• pDCs are defined by high surface TFRC expression and dynamic iron flux, distinguishing them from conventional dendritic cell subsets. • In the Iron proteome, pDC are enriched for mitochondrial heme and Fe–S proteins but have similar iron storage to cDC. • Iron chelation does not disrupt pDC type‐1 IFN production. ABSTRACT Plasmacytoid dendritic cells
Carrie Corkish, Simon O'Shaughnessy, Claire Lin, Sophia Wugk, Sarah Kenny, Linda Sinclair, Suzanne Cloonan, David Finlay   +7 more
wiley   +1 more source

CITRIN DEFICIENCY: AN INFANT INCIDENTALLY DETECTED BY PHENYLKETONURIA SCREENING WITH A NOVEL MUTATION IN SLC25A13 GENE

, 2015
Citrin deficiency: an infant incidentally detected by phenylketonuria screening with a novel mutation in SLC25A13 gene: We report the first Turkish patient with citrin deficiency detected incidentally by phenylketonuria screening.
Erkan, T., Zeybek, A. C. Aktuglu, CEYLANER, S., Kiykim, Ertuğrul, Zubarioglu, T., Cansever, M. S.   +5 more
core   +2 more sources

Hypoketotic hypoglycemia in citrin deficiency: a case report

BMC Pediatrics, 2020
Background Citrin deficiency (CD) is a recessive metabolic disease caused by biallelic pathogenic variants in SLC25A13. Although previous studies have reported ketosis in CD, it was observed at the time of euglycemia or mild hypoglycemia.
Yoichi Wada, Natsuko Arai-Ichinoi, Atsuo Kikuchi, Osamu Sakamoto, Shigeo Kure   +4 more
doaj   +1 more source

Energy metabolism, adenosine, and glutamate signaling reprogramming by decanoic acid in Glut1 disorder syndrome

Epilepsia Open, Volume 11, Issue 3, Page 1036-1045, June 2026.
Abstract Glut1 deficiency syndrome (Glut1DS) leads to neurological and cognitive symptoms and is primarily treated using carbohydrate‐restricted ketogenic diets. However, a recent clinical trial of a less restrictive, non‐ketogenic, medium chain triglyceride (MCT) diet with a high decanoic acid content suggests efficacy in Glut1DS treatment.
Erwann Pain, Yatra Kapatel, Pankaj K. Singh, Katie Lloyd Jones, Jamuna Selvakumaran, Alberto Malerba, Walter Lucchesi, Tricia Rutherford, Christina A. Gurnett, Matthew C. Walker, Robin S. B. Williams   +10 more
wiley   +1 more source

Pseudodendritic keratitis in citrullinemia; a report of an unusual and novel ocular finding in this metabolic disorder

American Journal of Ophthalmology Case Reports
Purpose: To report a 15 year old girl with citrullinemia type 1 and 2 accompanied by neurologic signs and symptoms and a novel ocular complaint in cornea like tyrosinemia type 2.
Davoud Amirkashani, Saeid Talebi, Mohammad Vafaei shahi, Ali Zekri, Parisa Abdi, Mahdokht Mehramiz   +5 more
doaj   +1 more source

Pedigree and Functional Analysis of Two Cryptic OTC Variants Causing Ornithine Transcarbamylase Deficiency in Two Unrelated Chinese Male Patients

Molecular Genetics &Genomic Medicine, Volume 14, Issue 5, May 2026.
Two unrelated Chinese male OTCD‐suspected patients harbored an OTC synonymous variant (c.663G>A, p.Lys221Lys) and a novel de novo in‐frame variant (c.756_761dupAGCAGC, p.Ala253_Ala254dup); minigene analysis confirmed the synonymous variant induces exon 6 skipping with 41 amino acid deletion (c.541_663del, p.Glu181_Lys221del).
Qingming Wang, Huimin Xiao, Fang Zhang, Hui Li, Juan Zhao, Haiming Yuan   +5 more
wiley   +1 more source