Results 61 to 70 of about 1,500 (175)
Design of Nanocarriers for Kidney Targeted Delivery of Nucleic Acid Therapeutics
Macromolecular Bioscience, Volume 26, Issue 7, July 2026.Nucleic acid therapeutics have been investigated to expand their applications to renal genetic disorders. This review summarizes key considerations in the design and fabrication of nanocarriers for the systemic delivery of nucleic acid therapeutics to the kidneys.
Jun Hyuk Lee +3 more
wiley +1 more source
Frontiers in Immunology, 2019 Porcine reproductive and respiratory syndrome virus (PRRSV) can cause respiratory disease and reproductive failure in pregnant pigs. Previous transcriptome analyses in susceptive cells have mainly concentrated on pulmonary alveolar macrophages (PAM) and ...
Kang Zhang +9 more
doaj +1 more source
KLINIČNI PRIMER BOLNIKA S CISTINURIJO
Slovenska pediatrija, 2020 Cistinurija je redka genetska bolezen, za katero je značilno pojavljanje ledvičnih kamnov. Klinično se kaže z ledveno bolečino, vročino ali hematurijo. »e bolezni ne zdravimo, lahko kamni zaprejo odtok urina in ogrozijo ledvico.
Matej Kemperle, Robert Kordič, Rina Rus
doaj +1 more source
Molecular Nutrition &Food Research, Volume 70, Issue 12, 28 June 2026.IPEC–J2 cell line is derived from piglet jejunal cells. Four different culture media were assessed for their ability to support IPEC‐J2 differentiation into an in vitro gut barrier. PS10 media proved most successful. Once differentiated with PS10, the IPEC‐J2 barrier was sufficiently robust for treatment with digested infant food. This demonstrates the
Francesca Bietto +6 more
wiley +1 more source
Efficient Screening of the Cystinuria-Related C663T Slc3a1 Nonsense Mutation in Newfoundland Dogs by Denaturing High-Performance Liquid Chromatography [PDF]
, 2006 Cystinuria in Newfoundland dogs is a metabolic disease associated with a nonsense mutation in the exon 2 of the Slc3a1 gene. Similar to type I human cystinuria, heterozygote carriers are not affected by the disease and do not reveal differences in ...
Cláudia Mascarenhas +3 more
core +1 more source
Pregnancy, Volume 2, Issue 3, May 2026.Abstract Carrier screening for genetic conditions performed preconception or during pregnancy allows identification of fetal risk for inherited autosomal recessive and X‐linked conditions. The goal is to identify at‐risk patients/couples and offer them reproductive options such as preimplantation genetic diagnosis, prenatal testing, or targeted newborn
Emily B. Rosenfeld +5 more
wiley +1 more source
Investigating Potential Therapies to Decrease the Rate of Cystine Stone Growth in Slc3a1-/- Mice [PDF]
, 2015 Cystinuria is an autosomal recessive disorder characterized by a defective renal transporter involved in the reabsorption of cystine and other dibasic amino acids. This leads to an accumulation of cystine in the urine, resulting in cystine stones.
Damodar, Sruthi
core +2 more sources
Clinical profile of a Polish cohort of children and young adults with cystinuria
Renal Failure, 2021 Background Cystinuria is an inherited disorder that results in increased excretion of cystine in the urine. It accounts for about 1–2% of pediatric kidney stones.
Marcin Tkaczyk +16 more
doaj +1 more source
Animals, 2023 Weaning is an important period that affects the performance of piglets. However, the regulation of dietary amino acid levels is considered to be an effective way to alleviate the weaning stress of piglets.
Naizhi Hu +7 more
doaj +1 more source
Advanced Science, Volume 13, Issue 17, 23 March 2026.This study emphasizes the role of the Mapk13‐Tcf1‐Slc7a5‐methionine metabolism axis in stem‐like CD4+ T cells. Moreover, it uncovers the mechanism through which limiting one‐carbon metabolism in CD4+ stem‐like T cells suppresses the tide of chronic allograft vasculopathy, offering potential targets to promote long‐term graft survival.
Wang Yi +8 more
wiley +1 more source