Results 151 to 160 of about 2,410 (172)

Identification of Appropriate Reference Genes for qPCR Analyses of Placental Expression of SLC7A3 and Induction of SLC5A1 in Porcine Endometrium [PDF]

Placenta, 2017
Endometria and placentae undergo developmental changes that affect the stability of genes used as references for normalization of qPCR data. We identified genes that are stable within the porcine endometrium and placenta throughout pregnancy, and elucidated the temporal/spatial mRNA localization of the glucose and arginine transporters, solute carrier ...
Guoyao Wu, Haijun Gao, Fuller W. Bazer
exaly   +3 more sources

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A Case of Congenital Glucose Galactose Malabsorption with a New Mutation in the SLC5A1 Gene

Journal of Pediatric Genetics, 2020
AbstractCongenital glucose-galactose malabsorption (CGGM) is an autosomal recessive disorder originating from an abnormal transporter mechanism in the intestines. It was sourced from a mutation in the SLC5A1 gene, which encodes a sodium-dependent glucose transporter.
Hasan Akduman, Dilek Dilli, Serdar Ceylaner   +2 more
openaire   +2 more sources

Circ_0003028 Enhances the Proliferation and Glycolytic Capacity and Suppresses Apoptosis in Non-Small Cell Lung Cancer Cells via the miR-1305/miR-1322-SLC5A1 Axis

Annals of Translational Medicine, 2023
Circular RNA (circRNA), a unique RNA molecule with a circular structure, is relevant to the process of non-small cell lung cancer (NSCLC). However, the role and possible mechanisms of circ_0003028 in NSCLC are not completely clear. Here, we investigated the role of circ_0003028 in NSCLC progression.We first confirmed the stability and head-to-tail ...
Bin Ke, Shaobing Chen
exaly   +3 more sources

Deoxynivalenol triggers porcine intestinal tight junction disorder through hijacking SLC5A1 and PGC1α-mediated mitochondrial function

Food and Chemical Toxicology, 2022
Deoxynivalenol (DON) is a mycotoxin frequently occurring in human and animal food worldwide, which raises increasing public health concerns. Growing evidence suggests that mitochondria is a pivotal molecular target for DON. However, the contribution of mitochondrial dysfunction to the pathogenesis of DON-induced gut epithelial barrier disruption ...
Dongfang, Xue, Ping, Yang, Yanyu, Yang, Yanan, Wang, Kuntan, Wu, Desheng, Qi, Shuai, Wang   +6 more
openaire   +2 more sources

Investigation of SLC6A9 and SLC5A1 as a promising therapeutic target for obesity and diabetes using in silico characterization, 3D structure prediction and molecular docking analysis

Alzheimer's & Dementia, 2023
AbstractBackgroundObesity is a multi‐factorial clinical condition resulting from energy dyshomeostasis. Obesity is known to be linked with the development of Type‐1 and Type‐2 diabetes due to abnormal glucose regulation. Additionally, it is associated with the onset of insulin resistance as well as atypical nutrient and hormonal sensing in the CNS. The
Jitendra Kumar Sinha, Shantanu Durgvanshi, Manish Verma, SHAMPA GHOSH   +3 more
openaire   +1 more source

Multiple sequence variations in SLC5A1 gene are associated with glucose-galactose malabsorption in a large cohort of Old Order Amish

Clinical Genetics, 2010
Glucose-galactose malabsorption (GGM) is an autosomal recessive disease with life-threatening newborn diarrhea caused by mutations in the Na(+) /glucose cotransporter gene SLC5A1. Because of its rarity, the clinical course of the disease has not been well studied.
B, Xin, H, Wang
openaire   +2 more sources

Identification of Candidate Causal Polymorphisms in GGT1 and SLC5A1 Associated With Fat Area Ratio on BTA17 in Japanese Black Cattle

Genes
Background/Objectives: Intramuscular fat deposition is a key determinant of beef quality in Japanese Black cattle, and the fat area ratio of the rib eye (FAR) is highly correlated with Beef Marbling Standard scores. Methods: To identify genetic variants underlying variation in the FAR, we conducted a genome-wide association study (GWAS) followed by ...
Hideyuki Mannen, Kenji Oyama, Shinji Sasazaki   +2 more
exaly   +2 more sources

SODIUM-D-GLUCOSE COTRANSPORTER SGLT1 (SLC5A1) IN MOUSE

2013
A high affinity/low capacity sodium-D-glucose cotransporter Sglt1 (Slc5a1) in the brush-border membrane (BBM) of small intestine (SI) and renal proximal tubule (PT) mediates glucose (re)absorption. A detailed localization of Sglt1 (mSglt1) along the nephron, and possibly in other mouse organs is unknown.
Breljak, Davorka, Vrhovac Madunić, Ivana, Sabolić, Ivan   +2 more
openaire  

SLC5A1 Mutations in Saudi Arabian Patients With Congenital Glucose‐Galactose Malabsorption

Journal of Pediatric Gastroenterology and Nutrition, 2018
ABSTRACTCongenital glucose‐galactose malabsorption (cGGM) is a rare autosomal recessive disorder, caused by mutations in the SLC5A1 gene, encoding the sodium/glucose cotransporter 1, which may result in severe life‐threatening osmotic diarrhea due to the accumulation of unabsorbed sugars in the intestinal lumen.
Yasir, Al-Suyufi, Khalid, ALSaleem, Ali, Al-Mehaidib, Mohammed, Banemai, Wajeeh M, Aldekhail, Abdulhakim, Al-Muhandes, Manal, Mohammed, Rabab, Allam, Amani, Jambi, Khushnooda, Ramzan, Faiqa, Imtiaz   +10 more
openaire   +2 more sources

SODIUM-D-GLUCOSE COTRANSPORTER SGLT1 (SLC5A1) IN MOUSE ORGANS

2013
A high affinity/low capacity sodium-D-glucose cotransporter Sglt1 (Slc5a1) in the brush-border membrane (BBM) of small intestine (SI) and renal proximal tubule (PT) mediates glucose (re)absorption. A detailed localization of Sglt1 (mSglt1) along the nephron, and possibly in other mouse organs is unknown.
Vrhovac, Ivana, Breljak, Davorka, Koepsell, Hermann, Sabolić Ivan   +3 more
openaire   +1 more source