Results 71 to 80 of about 2,410 (172)
Medicinal Research Reviews, Volume 46, Issue 1, Page 238-271, January 2026.ABSTRACT Solute carrier transporters (SLCs) are integral membrane proteins that play pivotal roles in maintaining cellular homeostasis by mediating the transport of a diverse range of substrates across cell membranes. With their involvement in fundamental physiological processes such as nutrient uptake, neurotransmitter signaling, and drug transport ...
Majlen A. Dilweg +3 more
wiley +1 more source
Journal of Arrhythmia, Volume 41, Issue 6, December 2025.Mendelian randomization analyses suggest that genetic proxies for antidiabetic drug targets—KCNJ11/ABCC8, SLC5A2, and RXRB—reduce the risk of paroxysmal tachycardia (PT), right bundle branch block (RBBB), and atrial fibrillation (AF), respectively.
Zheng‐Qi Song +7 more
wiley +1 more source
Identification of hexose transporter genes expressed in Caco-2/TC7 cells.
, 2016 RNA was isolated from Caco-2/TC7 cells grown for 21 days and converted to cDNA. The presence of SGLT1 (slc5a1), GLUT2 (slc2a2), GLUT5 (slc2a5), GLUT1 (slc2a1) and GLUT3 (slc2A3) transcripts was undertaken by PCR.
Patrick O’Brien (1288800) +1 more
core +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: Transporters
British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +28 more
wiley +1 more source
The Journal of Physiology, Volume 603, Issue 24, Page 7751-7763, December 15, 2025.Abstract figure legend Human intestinal organoids were genetically modified to express a fluorescent protein in enteroendocrine cells (EECs), which were then separated by flow cytometry and analysed by single‐cell RNA sequencing. High numbers of human EECs were thereby available for cluster analysis and differential gene expression, revealing ...
Christopher A. Smith +7 more
wiley +1 more source
AntioxidantsCo-fermentation with bacteria and enzymes can reduce sugar content in palm kernel cake (PKC); however, the chemical changes and their effects on cell functionality are unclear. This study investigated the active components in pre-treated PKC extracts and
Hui Zeng +5 more
doaj +1 more source
Primer pairs used in the RT-PCR reaction.
, 2014 SLC7A1: solute carrier family 7 (cationic amino acid transporter, y+system), member 1; SLC7A7: solute carrier family 7 (amino acid transporter light chain, y+L system), member 7; SLC1A1: solute carrier family 1 (neuronal/epithelial high affinity ...
Jielin Duan (520729) +19 more
core +1 more source
Molecular Nutrition &Food Research, Volume 69, Issue 22, November 2025.Early‐life exposure of rats to high‐fat‐isocaloric diet leads to metabolically obese, normal‐weight phenotype, and impaired cognition. Hippocampal transcriptomic analysis reveals disruption in pathways linked to obesity and cognitive decline, which is mitigated by perinatal leptin supplementation. PBMC share common altered genes with hippocampus, which
Carmen García‐Ruano +3 more
wiley +1 more source
, 2014 Values are means, with standard deviations represented by vertical bars (n = 6).
Lian-qiang Che (567801) +6 more
core +1 more source
Aging Cell, Volume 24, Issue 11, November 2025.Intestinal stem cells occur in clusters, and the cycle time of stem cells increases with age. The age‐dependent decline in structural intestinal tissue homeostasis is associated with a decline in stem cell activity. Aging causes significant changes in intestinal gene expression; intermittent fasting from adulthood onwards results in a gene expression ...
Michael Kothmayer +12 more
wiley +1 more source