Results 61 to 70 of about 2,410 (172)

On why cancer cells require a great amount of glucose

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract The traditional thinking has been that cancer cells require a great amount of glucose to support their rapid growth, but the reality may be different. We have previously demonstrated that all cancer cells in The Cancer Genome Atlas harbor persistent Fenton reactions in their cytosol, which generate OH− ${\text{OH}}^{-}$ and ultimately kill the
Xuechen Mu, Aoran Liu, Rui Shi, Long Xu, Zhenyu Huang, Ye Zhang, Ying Xu   +6 more
wiley   +1 more source

Polymorphisms in glucose homeostasis genes are associated with cardiovascular and renal parameters in patients with diabetic nephropathy

Annals of Medicine, 2022
Background Diabetic nephropathy (DN) has become the major cause of end-stage kidney disease and is associated to an extremely high cardiovascular (CV) risk.Methods We screened 318 DN patients for 23 SNPs in four glucose transporters (SLC2A1, SLC2A2 ...
Sonia Mota-Zamorano, Luz M. González, Nicolás R. Robles, José M. Valdivielso, José C. Arévalo-Lorido, Juan López-Gómez, Guillermo Gervasini   +6 more
doaj   +1 more source

Necrotizing Enterocolitis in Preterm Pigs Is Associated with Increased Density of Intestinal Mucosa-Associated Bacteria Including Clostridium perfringens [PDF]

, 2015
Background: Necrotizing enterocolitis (NEC) is associated with changes in the luminal gut microbiota. It is not known whether the mucosa-associated microbiota is affected by NEC and stimulates inflammatory lesions.
Heegaard, P. M. H., Delègue, Camilla Lindholm, Sangild, Per T., Delègue, C. L., Støy, Ann Cathrine Findal, Skovgaard, K., Mølbak, Lars, Manurung, Sarmauli, Heegaard, Peter M. H., Thymann, Thomas, Skovgaard, Kerstin, Sangild, Per Torp   +11 more
core   +1 more source

Modeling and Characterization of Intestinal Senescence Using Human Organoids: Insights Into the Epithelial to Mesenchymal Transition

Journal of Cellular Physiology, Volume 241, Issue 5, May 2026.
Created in BioRender. Iting, L. (2025) https://BioRender.com/b38d196. ABSTRACT Intestinal senescence is an important factor in systemic aging and age‐related diseases; however, detailed studies have been limited due to the lack of robust experimental models.
Tatsuhiro Ayabe, Yu Takahashi, I‐Ting Lee, Takeshi Kokubo, Yoshio Yamauchi, Ryuichiro Sato   +5 more
wiley   +1 more source

Hepatic Steatosis Risk Is Positively Associated With Increased Intestinal Glucose Absorption

Diabetes, Obesity and Metabolism, EarlyView.
Braden D. Rose, Domenico Tricò, Christopher K. Rayner, Tongzhi Wu, Richard L. Young   +4 more
wiley   +1 more source

Cellular microenvironment of erythropoietin‐producing cells in hypoxic and injured mouse kidneys

Experimental Physiology, Volume 111, Issue 4, Page 2236-2267, 1 April 2026.
Abstract The main sources of circulating erythropoietin (Epo) in the adult are kidney Norn cells, a recently identified interstitial cell type capable of becoming renal Epo‐producing (REP) cells following a local decrease in tissue oxygenation. REP cells are restricted to small clusters in the corticomedullary border region, suggesting that their ...
Olga M. Lempke, Thomas Knöpfel, Stellor Nlandu Khodo, Roland H. Wenger   +3 more
wiley   +1 more source

Evolution and developmental expression of the sodium–iodide symporter (NIS, slc5a5) gene family: Implications for perchlorate toxicology

Evolutionary Applications, 2022
The vertebrate sodium–iodide symporter (NIS or SLC5A5) transports iodide into the thyroid follicular cells that synthesize thyroid hormone. The SLC5A protein family includes transporters of vitamins, minerals, and nutrients. Disruption of SLC5A5 function
Ann M. Petersen, Clayton M. Small, Yi‐Lin Yan, Catherine Wilson, Peter Batzel, Ruth A. Bremiller, C. Loren Buck, Frank A. vonHippel, William A. Cresko, John H. Postlethwait   +9 more
doaj   +1 more source

Krisanaklan Reduces Intestinal Anion and Fluid Secretion Through Inhibition of Na+/K+‐ATPase and K+ Channel Activity

Annals of the New York Academy of Sciences, Volume 1556, Issue 1, February 2026.
Krisanaklan reduces CFTR‐dependent intestinal chloride and fluid secretion by inhibiting the Na+,K+‐ATPase and K+ channels in epithelial cells. Consequently, this natural, plant‐derived product may limit secretory diarrhea caused by a diverse array of microbial pathogens. However, by dissipating the transmembrane Na+ gradient, Krisanaklan also inhibits
Tessa A. Groeneweg, Erdene Baigal, Anny Leung, Gert‐Jan Kremers, Marcel J. C. Bijvelds   +4 more
wiley   +1 more source

Congenital glucose-galactose malabsorption: A case report about cause and consequence, not exactly in this order

Global Pediatrics
Congenital glucose-galactose malabsorption (CGGM) is a rare metabolic disorder caused by a deficient intestinal sodium-dependent glucose cotransporter (SGLT1) protein.
Rafaella Mergener, Marcela Rodrigues Nunes, Lívia Polisseni Cotta Nascimento, Victória Feitosa Muniz, Carla Graziadio, Paulo Ricardo Gazzola Zen   +5 more
doaj   +1 more source

A Proteochemometric Model for Ligands of the SLC5 Transporter Family

Archiv der Pharmazie, Volume 359, Issue 1, January 2026.
A novel proteochemometric model was developed to predict the activity and selectivity of SLC5 family inhibitors. The model's performance was validated using 10‐fold cross‐validation on publicly available datasets achieving Q2 = 0.79 and MSE < 0.32. Detailed analysis of the results enabled the identification of a new, previously unrecognized selectivity‐
Martin Juhás, Gerhard Ecker
wiley   +1 more source