Results 41 to 50 of about 2,410 (172)

The Molecular Basis of Glucose Galactose Malabsorption in a Large Swedish Pedigree

Function, 2021
Glucose-galactose malabsorption (GGM) is due to mutations in the gene coding for the intestinal sodium glucose cotransporter SGLT1 (SLC5A1). Here we identify the rare variant Gln457Arg (Q457R) in a large pedigree of patients in the Västerbotten County in
M Pilar Lostao, Donald D Loo, Olle Hernell, Gunnar Meeuwisse, Martin G Martin, Ernest M Wright   +5 more
doaj   +1 more source

Intestinal gluconeogenesis is downregulated in pediatric patients with celiac disease

BMC Medicine, 2022
Background Untreated celiac disease (CD) patients have increased levels of blood glutamine and a lower duodenal expression of glutaminase (GLS). Intestinal gluconeogenesis (IGN) is a process through which glutamine is turned into glucose in the small ...
Olof Karlson, Henrik Arnell, Audur H. Gudjonsdottir, Daniel Agardh, Åsa Torinsson Naluai   +4 more
doaj   +1 more source

Single nucleotide polymorphisms in the bovine SLC2A12 and SLC5A1 glucose transporter genes – the effect on gene expression and milk traits of Holstein Friesian cows

Animal Biotechnology, 2021
In this study, novel single nucleotide polymorphisms (SNPs) were found in the 5′-regulatory regions (promoters) of the bovine glucose transporter (GT) genes SLC2A12 and SLC5A1. These polymorphisms were shown to associate with certain milk production traits in HF cows, including milk yield, milk composition, and somatic cell count. It was shown that the
Lech, Zwierzchowski, Małgorzata, Ostrowska, Beata, Żelazowska, Emilia, Bagnicka   +3 more
openaire   +2 more sources

Host–pathogen interactions and genetic selection for resilience to post-weaning diarrhea in piglets

Animal Nutriomics
Rapid etiological diagnosis of diarrheal disease is challenging in multi-pathogen settings. Host blood transcriptomes provide a pathogen-agnostic signal, but models must be accurate and interpretable. We analyzed peripheral blood transcriptomes from pigs
Yige Li, Luoyi Zhu, Shuqi Liu, Liang Huang, Sai Xiao, Erjia Hou, Yan Xuan, Xin Zong   +7 more
doaj   +1 more source

Development of the gastrointestinal tract of newborn goats under maternal feed restriction at different stages of gestation

Revista Brasileira de Zootecnia, 2023
This study evaluated how nutritional insults applied at different stages of intrauterine development affect the growth and development of total tract organs and the mRNA expression of genes that encode growth factors, tight junction proteins, digestive ...
Luana Ruiz dos Santos, Thaís Correia Costa, Ranyeri Oliveira Souza, Tathyane Ramalho Santos Gionbelli, Ivam Moreira de Oliveira Junior, Germán Darío Ramírez-Zamudio, Karolina Batista Nascimento, Marcio de Souza Duarte, Mateus Pies Gionbelli   +8 more
doaj   +1 more source

Loss of endometrial sodium glucose cotransporter SGLT1 is detrimental to embryo survival and fetal growth in pregnancy

, 2017
Embryo implantation requires a hospitable uterine environment. A key metabolic change that occurs during the peri-implantation period, and throughout early pregnancy, is the rise in endometrial glycogen content.
Madunić, Ivana Vrhovac, Diethelm Wallwiener, Brucker, Sara Y., Chen, Hong, Ursula Kohlhofer, Breljak, Davorka, Vrhovac Madunić, Ivana, Madhuri S. Salker, Ivan Sabolić, Hajar Fakhri, Anja T Umbach, Sabolić, Ivan, Pavle Vrljicak, Hong Chen, Ruban R. Peter Durairaj, Kohlhofer, Ursula, Sara Y Brucker, Ivana Vrhovac Madunić, Shaqiu Zhang, Hermann Koepsell, Zeng, Ni, Barros, Flavio S. V., Yogesh Singh, Quintanilla-Martinez, Leticia, Fakhri, Hajar, Ni Zeng, Sascha Ott, Singh, Yogesh, Lang, Florian, Jan J. Brosens, Zhang, Shaqiu, Flavio S. V. Barros, Davorka Breljak, Brosens, Jan J., Salker, Madhuri S., Durairaj, Ruban R. Peter, Koepsell, Hermann, Florian Lang, Umbach, Anja T, Leticia Quintanilla-Martinez, Brucker, Sara Y, Umbach, Anja T., Ott, Sascha, Wallwiener, Diethelm, Vrljicak, Pavle   +44 more
core   +1 more source

The gene expression of SLC5A2 and SLC5A1 in human pancreatic islets correlated with glucagon gene expression.

, 2016
The mRNA expression of SLC5A1 (panel A, n = 131, r = 0.53, q ...
Emilia Ottosson-Laakso (843794), Monika Gullström (843796), Petter Vikman (62474), Per-Henrik Groop (135217), Leif Groop (12005), Tiinamaija Tuomi (12004), Björn Forsén (843795)   +6 more
core   +1 more source

Evaluating integrative strategies for incorporating phenotypic features in spatial transcriptomics

Journal of Microscopy, EarlyView.
Abstract The key advantage of spatial transcriptomics (ST) technologies lies in the spatial domain: these techniques not only offer an unprecedented opportunity to interrogate intact biological samples in a spatially informed manner, but also set the stage for integration with other imaging‐based modalities.
Levin M Moser, Ahmad Kamal Hamid, Esteban Miglietta, Nodar Gogoberidze, Beth A Cimini   +4 more
wiley   +1 more source

SGLT1 Deficiency Turns Listeria Infection into a Lethal Disease in Mice

Cellular Physiology and Biochemistry, 2017
Background: Cellular glucose uptake may involve either non-concentrative glucose carriers of the GLUT family or Na+-coupled glucose-carrier SGLT1, which accumulates glucose against glucose gradients and may thus accomplish cellular glucose uptake even at
Piyush Sharma, Vishal Khairnar, Ivana Vrhovac Madunić, Yogesh Singh, Aleksandra Pandyra, Madhuri S. Salker, Hermann Koepsell, Ivan Sabolić, Florian Lang, Philipp A. Lang, Karl S. Lang   +10 more
doaj   +1 more source

A review of xenobiotic membrane transporter expression within the human placenta: Lessons gained from primary tissue and in vitro methodologies

The Journal of Physiology, EarlyView.
Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass, Kathryn Wolton, Amanda N. Sferruzzi‐Perri   +2 more
wiley   +1 more source