Results 31 to 40 of about 2,410 (172)

Congenital glucose‐galactose malabsorption: A case report with a novel SLC5A1 mutation [PDF]

Clinical Case Reports, 2018
Key Clinical MessageA three‐day‐old newborn girl presented with decreased feeding and dehydration. She was sick and in shock. She had renal impairment and hypernatremia. With the resumption of breast feeding, she developed watery stools and hypernatremia. Glucose‐Galactose Malabsorption was suspected and confirmed by the presence of a likely pathogenic
Manar Al‐lawama, Jumana Albaramki, Mutaz Altamimi, Hatem El‐Shanti   +3 more
openaire   +2 more sources

A risk model of gene signatures for predicting platinum response and survival in ovarian cancer

Journal of Ovarian Research, 2022
Background Ovarian cancer (OC) is the deadliest tumor in the female reproductive tract. And increased resistance to platinum-based chemotherapy represents the major obstacle in the treatment of OC currently. Robust and accurate gene expression models are
Siyu Chen, Yong Wu, Simin Wang, Jiangchun Wu, Xiaohua Wu, Zhong Zheng   +5 more
doaj   +1 more source

Promotion of Cyst Formation from a Renal Stem Cell Line Using Organ-Specific Extracellular Matrix Gel Format Culture System

Gels, 2022
Researchers have long awaited the technology to develop an in vitro kidney model. Here, we establish a rapid fabricating technique for kidney-like tissues (cysts) using a combination of an organ-derived extracellular matrix (ECM) gel format culture ...
Yusuke Sakai, Yoshihiro Kubo, Nana Shirakigawa, Yoshinori Kawabe, Masamichi Kamihira, Hiroyuki Ijima   +5 more
doaj   +1 more source

Inhibition of mitochondrial function by metformin increases glucose uptake, glycolysis and GDF-15 release from intestinal cells

Scientific Reports, 2021
Even though metformin is widely used to treat type2 diabetes, reducing glycaemia and body weight, the mechanisms of action are still elusive. Recent studies have identified the gastrointestinal tract as an important site of action.
Ming Yang, Tamana Darwish, Pierre Larraufie, Debra Rimmington, Irene Cimino, Deborah A. Goldspink, Benjamin Jenkins, Albert Koulman, Cheryl A. Brighton, Marcella Ma, Brian Y. H. Lam, Anthony P. Coll, Stephen O’Rahilly, Frank Reimann, Fiona M. Gribble   +14 more
doaj   +1 more source

Stx2 Induces Differential Gene Expression and Disturbs Circadian Rhythm Genes in the Proximal Tubule

Toxins, 2022
Shiga toxin-producing Escherichia coli (STEC) causes proximal tubular defects in the kidney. However, factors altered by Shiga toxin (Stx) within the proximal tubules are yet to be shown.
Fumiko Obata, Ryo Ozuru, Takahiro Tsuji, Takashi Matsuba, Jun Fujii   +4 more
doaj   +1 more source

Fructose Metabolism and Its Effect on Glucose-Galactose Malabsorption Patients: A Literature Review

Diagnostics, 2023
Glucose-galactose malabsorption is a rare inherited autosomal recessive genetic defect. A mutation in the glucose sodium-dependent transporter-1 gene will alter the transportation and absorption of glucose and galactose in the intestine.
Nawaf W. Alruwaili, Fahad Alshdayed
doaj   +1 more source

Local environment‐driven adaptive evolution in a marine invasive ascidian (Molgula manhattensis)

Ecology and Evolution, 2021
Elucidating molecular mechanisms of environment‐driven adaptive evolution in marine invaders is crucial for understanding invasion success and further predicting their future invasions.
Yiyong Chen, Yangchun Gao, Xuena Huang, Shiguo Li, Aibin Zhan   +4 more
doaj   +1 more source

Changes in the gut microbiome during fasting‐induced molting and its effects on gut–liver function [PDF]

IMetaOmics
During fasting, harmful microbiota and metabolites rise, triggering intestinal injury and activation of the TGF‐β signaling pathway, which enhances intestinal stem cell proliferation. Concurrently, hepatic function declines, indicated by increased hepatic and serum bile acids and upregulation of the non‐classical bile acid synthesis pathway.
Zhang H, Luo Z, Zhang J, Wang C, Tian Y, Li D, Guo Y, Zhang Y, Li W, Gong Y, Kang X, Jiang R.   +11 more
europepmc   +2 more sources

Integration analysis of metabolome and transcriptome reveals the effect of exogenous supplementation with mixtures of vitamins ADE, zinc, and selenium on follicular growth and granulosa cells molecular metabolism in donkeys (Equus asinus)

Frontiers in Veterinary Science, 2022
Vitamins and microelements play essential roles in mammalian ovarian physiology, including follicle development, ovulation, and synthesis and secretion of hormones and growth factors.
Yajun Guo, Weisen Zhao, Nan Li, Shizhen Dai, Hao Wu, Zhenlong Wu, Shenming Zeng   +6 more
doaj   +1 more source

Correction: Brosch et al. Glucose and Inositol Transporters, SLC5A1 and SLC5A3, in Glioblastoma Cell Migration. Cancers 2022, 14, 5794

Cancers, 2023
Philipp Kreisz was not included as an author in the original publication [...]
Philippa K. Brosch, Tessa Korsa, Danush Taban, Patrick Eiring, Philipp Kreisz, Sascha Hildebrand, Julia Neubauer, Heiko Zimmermann, Markus Sauer, Ryo Shirakashi, Cholpon S. Djuzenova, Dmitri Sisario, Vladimir L. Sukhorukov   +12 more
openaire   +1 more source