Results 21 to 30 of about 2,410 (172)

Phylogenetic Relations and High-Altitude Adaptation in Wild Boar (Sus scrofa), Identified Using Genome-Wide Data

Animals
The Qinghai–Tibet Plateau (QTP) wild boar is an excellent model for investigating high-altitude adaptation. In this study, we analyzed genome-wide data from 93 wild boars compiled from various studies worldwide, including the QTP, southern and northern ...
Shiyong Fang, Haoyuan Zhang, Haoyuan Long, Dongjie Zhang, Hongyue Chen, Xiuqin Yang, Hongmei Pan, Xiao Pan, Di Liu, Guangxin E   +9 more
doaj   +2 more sources

Polymorphism analysis of AMY1, AMY2, SLC5A1, SLC2A2 and SLC2A5 genes in Italian horse breeds

, 2013
The dietary demand of modern competition horse relies on high-cereal feeding daily interspersed by limited forage and it is frequently characterized by marked changes in carbohydrate fractions, above all starch, compared to natural grazing conditions.
B. Coizet, L.G.M. Nicoloso, D. Marletta, P. Crepaldi, S. Frattini, G.G.A. Pagnacco   +5 more
openaire   +3 more sources

A new link between insulinoma and congenital glucose-galactose malabsorption

Endocrine Oncology
Congenital glucose-galactose malabsorption (CGGM) is a rare autosomal recessive disorder caused by a biallelic mutation of solute carrier family 5 member 1 (SLC5A1), encoding the sodium-dependent glucose transport-1 (SGLT-1) protein.
Antonio Prinzi, Jelka Kuiper, Adorée M van der Wiel, Marie-Louise F van Velthuysen, Remco T P van Cruchten, Lodewijk A A Brosens, Wouter W de Herder, Johannes Hofland   +7 more
doaj   +2 more sources

Differential changes in anatomical, molecular and functional determinants of intestinal glucose absorption during murine pregnancy [PDF]

Physiological Reports
Pregnancy demands increased food intake and nutrient delivery to support the growing conceptus. The timing and regional specificity of adaptations in small intestinal (SI) anatomy and transport, and their functional consequences, remain unclear.
T. Sebastian Overduin, Georgia S. Clarke, Hui Li, Richard L. Young, Kathryn L. Gatford, Amanda J. Page   +5 more
doaj   +2 more sources

10 Pre-clinical studies of sotagliflozin in hypertrophic cardiomyopathy

Journal of Clinical and Translational Science
OBJECTIVES/GOALS: Study the regulatory role of sodium glucose co-transporter 1 (SGLT1) in cardiomyocytes and the therapeutic potential of sotagliflozin in hypertrophic cardiomyopathy (HCM) by (a) quantifying SGLT1 expression in HCM and (b) examining the ...
Rebecca Taichman, Benjamin Lee, Kenneth Margulies, Sharlene Day   +3 more
doaj   +2 more sources

The Na+/glucose cotransporters: from genes to therapy

Brazilian Journal of Medical and Biological Research, 2010
Glucose enters eukaryotic cells via two types of membrane-associated carrier proteins, the Na+/glucose cotransporters (SGLT) and the facilitative glucose transporters (GLUT). The SGLT family consists of six members.
R. Sabino-Silva, R.C. Mori, A. David-Silva, M.M. Okamoto, H.S. Freitas, U.F. Machado   +5 more
doaj   +1 more source

A Rare Case of Congenital Glucose Galactose Malabsorption Due to SLC5A1 Mutation. [PDF]

Cureus
Protracted neonatal diarrhea is severe and potentially life-threatening if not promptly diagnosed and treated. Causes include congenital defects in sodium, chloride, glucose/galactose, bile acid transport, enterokinase deficiency, and villous atrophy.
Muralidharan H, Sajith A, ElSayed N, Syed Iqbaluddin J, Gupta P, Ahmed Babiker Rahamtalla D.   +5 more
europepmc   +3 more sources

Congenital Glucose-Galactose Malabsorption: A Case With a Novel SLC5A1 Mutation in a Saudi Infant [PDF]

Cureus, 2021
While only a few hundred cases have been reported in pediatrics, congenital glucose-galactose malabsorption (GGM) is an extremely rare autosomal-recessive metabolic disorder that is characterized by intractable diarrhea and severe dehydration, which can be life-threatening if not treated appropriately.
Alamoudi, Loujen O, Alfaraidi, Albaraa T, Althagafi, Samiyah S, Al-Thaqafy, Majid S, Hasosah, Mohammed   +4 more
openaire   +2 more sources

Identification of Candidate Causal Polymorphisms in <i>GGT1</i> and <i>SLC5A1</i> Associated with Fat Area Ratio on BTA17 in Japanese Black Cattle. [PDF]

Genes (Basel)
Background/Objectives: Intramuscular fat deposition is a key determinant of beef quality in Japanese Black cattle, and the fat area ratio of the rib eye (FAR) is highly correlated with Beef Marbling Standard scores. Methods: To identify genetic variants underlying variation in the FAR, we conducted a genome-wide association study (GWAS) followed by ...
Sasazaki S, Ito H, Adachi R, Iwamoto E, Yoshida E, Kawaguchi F, Oyama K, Mannen H.   +7 more
europepmc   +2 more sources

Co-segregation analysis and functional trial in vivo of candidate genes for monogenic diabetes

BMJ Open Diabetes Research & Care, 2022
Introduction The aim of this study was to perform familial co-segregation analysis and functional trial in vivo during mixed meal tolerance test (MMTT) of novel variants in diabetes candidate genes.Research design and methods It is a continuation of the ...
Jean-Louis Blouin, Ingrida Stankute, Mintaute Kazlauskiene, Valerie M Schwitzgebel, Rasa Verkauskiene   +4 more
doaj   +1 more source