Results 81 to 90 of about 241,963 (315)

Update on the Genetics of Systemic Lupus Erythematosus: Genome-Wide Association Studies and Beyond

Cells, 2019
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of complex etiology that primarily affects women of childbearing age. The development of SLE is attributed to the breach of immunological tolerance and the interaction between SLE ...
Young-Chang Kwon, Sehwan Chun, Kwangwoo Kim, Anselm Mak   +3 more
doaj   +1 more source

SLE Boundary Visits

Annales Henri Poincaré, 2015
We study the probabilities with which chordal Schramm-Loewner Evolutions (SLE) visit small neighborhoods of boundary points. We find formulas for general chordal SLE boundary visiting probability amplitudes, also known as SLE boundary zig-zags or order refined SLE multi-point Green's functions on the boundary.
Kytölä Kalle, Kytölä Kalle, Järvinen Matti, Jokela Niko   +3 more
openaire   +2 more sources

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, EarlyView.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

Discovery of Small Molecule Drugs Targeting the Biogenesis of microRNA-155 for the Treatment of Systemic Lupus Erythematosus

CHIMIA, 2020
ystemic lupus erythematosus (SLE) is an autoimmune disease that often leads to functional disorder in multiple organs, most often with symptoms related to skin lesions, cardiovascular disease and kidney damage. Although significant efforts have been made
Kamal Azzaoui, Marcel Blommers, Marjo Götte, Kaspar Zimmermann, He Liu, Heinz Fretz   +5 more
doaj   +1 more source

Mendelian Randomization and Double Machine Learning Modeling Reveal Brain Imaging‐Derived Phenotypes as Functional Contributors to 18 Autoimmune Inflammatory Diseases

Advanced Science, EarlyView.
This schematic integrates the eight statistically significant causal relationships identified between 1,366 brain imaging‐derived phenotypes (IDPs) and 18 autoimmune inflammatory diseases (AIDs). Arrows indicate the direction of causality inferred from bidirectional two‐sample MR analyses.
Jinbin Chen, Xin Wang, Haifeng Ding, Bosheng Zheng, Keni Zeng, Chuying Hu, Jiayi Liu, Xiao Zhu, Haibing Yu   +8 more
wiley   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Is There a Future for Anti-CD38 Antibody Therapy in Systemic Autoimmune Diseases?

Cells, 2019
CD38 is a type II glycoprotein highly expressed on plasmablasts, short-lived and long-lived plasma cells, but weakly expressed on other lymphoid cells, myeloid cells and non-hematopoietic cells.
Devis Benfaremo, Armando Gabrielli
doaj   +1 more source

Reprogramming M2b Macrophages via GPX1 Activation by Selenium Nanoparticles Attenuates Lupus Nephritis

Advanced Science, EarlyView.
SeZM NPs selectively target M2b macrophages through mannose–MRC1 (CD206) recognition, enhance GPX1 biosynthesis, and suppress mitochondrial ROS generation, oxidative stress, and JAK–STAT signaling. This dual regulation reduces pro‐inflammatory cytokine release, limits immune cell infiltration and fibrosis, and preserves renal function, providing a ...
Haoran Lv, Guanning Huang, Hongyu Li, Hanzhi Liang, Huajing Peng, Kefei Wu, Wenfang Chen, Dandan Zhang, Kexin Ma, Yufei Du, Siweier Luo, Yi Zhou, Haiping Mao, Wei Chen, Tianfeng Chen, Yiming Zhou, Qinghua Liu   +16 more
wiley   +1 more source

Molecular‐Scale Tuning of Low‐Molecular‐Weight Gelators Controls Supramolecular Assembly and Directs Human Mesenchymal Stem Cell Growth

Angewandte Chemie, EarlyView.
Chemistry in charge of biology! Simple low‐molecular‐weight gelators, with minor modifications in molecular structure, self‐assemble differently and can also co‐assemble when simultaneously triggered. This creates a family of gels with different properties that direct the growth of stem cells in different ways.
Chayanan Tangsombun, Amy Simpson, Rebecca L. Charlton, Lucy E. Sabin, Paul G. Genever, David K. Smith   +5 more
wiley   +2 more sources

The pathological role of B cells in systemic lupus erythematosus: From basic research to clinical

Autoimmunity, 2020
Systemic lupus erythematosus (SLE) is an autoimmune disease that often occurs in females of child-bearing age. It involves multiple systems and severely threatens human life.
Yu Feng, Ming Yang, Haijing Wu, Qianjin Lu   +3 more
doaj   +1 more source