Results 101 to 110 of about 49,955 (299)

An n‐of‐1 gene‐directed drug repurposing trial for an ultrarare genetic condition

Epilepsia, EarlyView.
Abstract Objective Gain‐of‐function (GoF) variants in the KCNC1 potassium channel subunit gene (Kv3.1) cause motor/cognitive delays and hypotonia and have been associated with seizures. Fluoxetine has inhibitory effects on Kv3.1. However, open‐label nonrandomized administration is insufficient to guide clinical decision‐making in ultrarare conditions ...
Vedika Jha, Christina Tsetsos, Mark Bedford, Gregory Costain, Sunita Vohra, Juan Pablo Diaz Martinez, Elise Heon, Jacob Vorstman, Carolina Gorodetsky, Ajoy Vincent, Jesiqua Rapley, Lori Anderson, Evdokia Anagnostou, Danielle A. Baribeau   +13 more
wiley   +1 more source

Lithium Prevents REM Sleep Deprivation-Induced Impairments on Memory Consolidation

, 2013
Background: Pre-training rapid eye movement sleep (REMS) deprivation affects memory acquisition and/or consolidation. It also produces major REMS rebound at the cost of waking and slow wave sleep (SWS). Given that both SWS and REMS appear to be important
Ota, Simone Marie [UNIFESP], Moreira, Karin Di Monteiro [UNIFESP], Suchecki, Deborah [UNIFESP], Tiba, Paula Ayako [UNIFESP], Oliveira, Maria Gabriela Menezes de [UNIFESP]   +4 more
core   +1 more source

Are comorbid sleep disorders associated with higher risk for sudden unexpected death in epilepsy? Observations from a Canadian epilepsy clinic

Epilepsia, EarlyView.
Abstract Objective Pooled mortality is nearly three times higher in people with epilepsy (PWE). Approximately 80% of sudden unexpected death in epilepsy (SUDEP) events occur during sleep, and primary sleep disorders are prevalent in the general population and PWE.
Marion Lazaj, Ellen Lee, Tristan Derry, Helen Driver, Gavin P. Winston, Lysa Boissé Lomax, Ana Johnson, Garima Shukla   +7 more
wiley   +1 more source

Isolated Rem Sleep Behavior Disorder: A Model to Assess the Overnight Habituation of Emotional Reactivity

Clocks & Sleep
(1) Background: Phasic events in rapid eye movement (REM) sleep are a core feature of isolated REM behavior disorder (iRBD), which is often associated with emotion dysregulation.
Caterina Leitner, Viviana Greco, Francesca Casoni, Penelope A. Lewis, Luigi Ferini-Strambi, Andrea Galbiati   +5 more
doaj   +1 more source

Chemogenetic inhibition of the medial prefrontal cortex reverses the effects of REM sleep loss on sucrose consumption

eLife, 2016
Rapid eye movement (REM) sleep loss is associated with increased consumption of weight-promoting foods. The prefrontal cortex (PFC) is thought to mediate reward anticipation.
Kristopher McEown, Yohko Takata, Yoan Cherasse, Nanae Nagata, Kosuke Aritake, Michael Lazarus   +5 more
doaj   +1 more source

Dopamine Transporter Regulation during Four Nights of REM Sleep Deprivation Followed by Recovery - An in vivo Molecular Imaging Study in Humans

, 2010
Objectives: To assess the influence of total or selective REM sleep deprivation on the dopamine transporter (DAT) densities and sleep patterns of healthy volunteers.Design: Prospective study.Setting: Evaluation of polysomnography recordings and DAT ...
Bittencourt, Lia Rita Azeredo [UNIFESP], Hoexter, M. Q. [UNIFESP], Andersen, Monica Levy [UNIFESP], Guindalini, Camila [UNIFESP], Tufik, Sergio [UNIFESP], Bressan, Rodrigo Affonseca. A. [UNIFESP], Garbuio, Silvério Aparecido [UNIFESP], Martins, R. C. S. [UNIFESP], Shih, M. C. [UNIFESP], Castiglioni, M. L. V. [UNIFESP]   +9 more
core   +1 more source

Timing is everything: The effect of early‐life seizures on developing neuronal circuits subserving spatial memory

Epilepsia Open, EarlyView.
Abstract Spatial memory, the aspect of memory involving encoding and retrieval of information regarding one's environment and spatial orientation, is a complex biological function incorporating multiple neuronal networks. Hippocampus‐dependent spatial memory is not innate and emerges during development in both humans and rodents.
Gregory L. Holmes
wiley   +1 more source

Antidepressant suppression of REM and spindle sleep impairs hippocampus-dependent learning and memory but fosters striatal-dependent strategies

, 2011
REM sleep enhances hippocampus-dependent associative memory but has little impact on striatal-dependent procedural learning. Antidepressant medications like desipramine (DMI) inhibit rapid-eye-movement (REM) sleep but it is little understood how ...
Jamie Sweigart, Alain Watts, Howard Gritton, Gina Poe   +3 more
core  

Frontiers in EEG as a tool for the management of pediatric epilepsy: Past, present, and future

Epilepsia Open, EarlyView.
Abstract Electroencephalography (EEG) has evolved into an indispensable tool in pediatric epilepsy, fundamentally transforming the diagnosis, classification, and management of this condition. This review chronicles the historical journey of EEG from its groundbreaking inception to its current pivotal role in delineating distinct pediatric epilepsy ...
Hiroki Nariai
wiley   +1 more source

Hypnotic and Sleep Quality–Enhancing Properties of Kavain in Sleep-Disturbed Rats

Journal of Pharmacological Sciences, 2009
The present study was performed to investigate the effects of kavain on the sleep-wake cycle in comparison with that of rilmazafone and diphenhydramine using sleep-disturbed rats.
Ryuki Tsutsui, Kazuaki Shinomiya, Yasuhiro Takeda, Yoshihito Obara, Yoshihisa Kitamura, Chiaki Kamei   +5 more
doaj   +1 more source