Results 51 to 60 of about 1,127,789 (293)

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

open access: yesFEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi   +2 more
wiley   +1 more source

Irisin Is Correlated with Blood Pressure in Obstructive Sleep Apnea Patients

open access: yesInternational Journal of Hypertension, 2021
Background. Despite approximately 95% primary cases of hypertension, secondary hypertension seems to be common with resistant forms. Notably, obstructive sleep apnea (OSA) is known as a common cause of secondary hypertension and has a major ...
Xing Wang   +6 more
doaj   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

open access: yesFEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui   +15 more
wiley   +1 more source

About sleep's role in memory.

open access: yesPhysiological Reviews, 2013
Over more than a century of research has established the fact that sleep benefits the retention of memory. In this review we aim to comprehensively cover the field of "sleep and memory" research by providing a historical perspective on concepts and a ...
B. Rasch, J. Born
semanticscholar   +1 more source

DICOM attribute manipulation tool: Easily change frame of reference, series instance, and SOP instance UID

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose In radiation oncology, the integration and registration of multiple imaging modalities is a crucial aspect of the diagnosis and treatment planning process. These images are often inherently registered, a useful feature in most cases, but possibly a hindrance when registration modifications are required.
Brian M. Anderson, Casey Bojechko
wiley   +1 more source

Numerical modeling of the effects of roughness on flow and eddy formation in fractures

open access: yesJournal of Rock Mechanics and Geotechnical Engineering, 2017
The effect of roughness on flow in fractures was investigated using lattice Boltzmann method (LBM). Simulations were conducted for both statistically generated hypothetical fractures and a natural dolomite fracture.
Scott Briggs   +2 more
doaj   +1 more source

Eye movement patterns correlate with overt emotional behaviours in rapid eye movement sleep

open access: yesScientific Reports, 2022
Growing evidence suggests that sleep plays a key role in regulating emotions. Rapid eye movements (REMs) in REM sleep could be associated with dreams emotions, but supporting evidence is indirect.
Jean-Baptiste Maranci   +8 more
doaj   +1 more source

The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation.

open access: yesSleep, 2003
OBJECTIVES To inform the debate over whether human sleep can be chronically reduced without consequences, we conducted a dose-response chronic sleep restriction experiment in which waking neurobehavioral and sleep physiological functions were monitored ...
H. V. Van Dongen   +3 more
semanticscholar   +1 more source

The burden of burnout: Understanding its prevalence and organizational drivers in medical physics

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract Background Burnout is a work‐related syndrome characterized by increased levels of emotional exhaustion (EE) and depersonalization (DP) along with decreased levels of personal achievement. In the healthcare setting, higher burnout levels have been associated with negative impacts on personnel, an increased risk of errors, and a decrease in the
Deborah Schofield   +4 more
wiley   +1 more source

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