Results 121 to 130 of about 158,325 (315)

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

The association between sleep problems, learning disabilities and substance use in adolescence

, 2007
Includes bibliographical references (leaves 90-112)The current study focused on investigating the relationship between sleep problems, learning disabilities and substance use in adolescence.
Fakier, Nuraan
core  

Assessing the Impact of Two Sleep Interventions on ‘Normal’ Children’s Sleep Practices [PDF]

, 2013
Insufficient sleep duration in preschool children has been associated with adverse health consequences, including increased risk of obesity; impaired reaction time, attention, memory and behaviour regulation and reduced academic performance. Very little
NEWARK, MEGAN,ELIZABETH
core  

Sleep Patterns and Disturbances in Children Aged 6-16 Years During the COVID-19 Pandemic in Türkiye [PDF]

Objective: This study aimed to evaluate the factors causing sleep patterns and disturbances in children during the coronavirus disease-2019 (COVID-19) pandemic.
Aysel Topan, Özlem Öztürk Şahin, Yeliz Taşdelen   +2 more
core   +1 more source

Sleep disturbances in older surgical patients with and without suspected cognitive impairment: A multicenter cohort study.

PLoS ONE
AimsEarly detection and management of sleep disturbances can improve postoperative outcomes given the high prevalence of sleep disturbances and unrecognized cognitive impairment in older surgical patients.
Nina Butris, Ellene Yan, Yasmin Alhamdah, Paras Kapoor, Leif Erik Lovblom, Aparna Saripella, David Gold, Jean Wong, David F Tang-Wai, Linda Mah, Mark I Boulos, David He, Frances Chung   +12 more
doaj   +1 more source

Sleep in adolescents and young adults with type 1 diabetes: associations with diabetes management and glycemic control

Health Psychology and Behavioral Medicine, 2016
Objective: To describe sleep in adolescents and young adults with type 1 diabetes (T1D) and explore the association between sleep disturbances, diabetes management and glycemic control. Methods: Adolescents with T1D (n = 159, mean age = 16.4, 43% female,
Sarah S. Jaser, Deborah Ellis
doaj   +1 more source

Long‐Term Ambient Benzene Exposure and Brain Disorders Among Urban Adults: Effect Modification by Genetic Susceptibility and Potential Mediation by Plasma Proteins

Advanced Science, EarlyView.
Low‐level ambient benzene exposure is associated with increased risks of multiple brain disorders in urban adults. Genetic susceptibility modifies these associations, while plasma proteomics points to potential biological pathways linking benzene exposure to adverse brain health.
Jianhui Guo, Xia Zhong, Petros Koutrakis, Carolina L. Zilli Vieira, Feifei Si, Yaqi Wang, Xinyao Lian, Yi Fan, Zhaokun Wang, Shaodan Huang, Jing Li   +10 more
wiley   +1 more source

Pharmacological Inhibition of FKBP51 Mitigates Early Life Adversity‐Induced Social Deficits in Male Mice

Advanced Science, EarlyView.
Early life adversity triggers persistent social subordination and brain‐wide molecular dysregulation. Pharmacological inhibition of the stress‐mediator FKBP51 during the adversity period prevents these long‐term deficits and restores normative social hierarchy.
Joeri Bordes, Xiuqi Ji, Serena Gasperoni, Choham Sudre‐Chinsky, Amirali Kalbasi, Daniela Harbich, Cornelia Flachskamm, Paula Fontanet, Sowmya Narayan, Manfred Uhr, Christian Namendorf, Camilla Bellone, Alon Chen, Felix Hausch, Juan Pablo Lopez, Mathias V. Schmidt   +15 more
wiley   +1 more source

Sleep disturbances and suicide risk: A review of the literature

, 2007
Rebecca A Bernert, Thomas E JoinerDepartment of Psychology, Florida State University, Tallahassee, FL, USAAbstract: A growing body of research indicates that sleep disturbances are associated with suicidal ideation and behaviors.
Thomas E Joiner, Rebecca A Bernert
core  

The relationship between anemia and sleep disturbances among older Chinese adults: The mediating role of handgrip strength.

PLoS ONE
BackgroundSleep plays an important role in human health, and anemia can lead to a continuous deterioration of sleep. However, the association and mechanism between anemia and sleep disturbances remain unclear. This study aimed to examine the relationship
Jie Li, Zunyi Ma, Xiaojiang Zhao
doaj   +1 more source