Results 111 to 120 of about 703,277 (252)

An Investigation of Sleep Macro‐ and Microarchitecture by APOE Genotype

Annals of Neurology, EarlyView.
Objectives Apolipoprotein E ε4 (APOE ε4), a robust genetic risk factor for Alzheimer's disease (AD) is associated with functional connectivity deficits and amyloid pathology in brain regions involved in sleep regulation. Thus, alterations in sleep architecture may be one pathway through which ε4 contributes to Alzheimer's disease vulnerability. However,
Gawon Cho, Anne Chen, Eunyoung Choi, Orfeu M. Buxton, Daniel Kay, Adam Mecca, Brienne Miner   +6 more
wiley   +1 more source

Therapeutic Prospects of Ketamine for Cataplexy in Narcolepsy Type 1: Evidence from a Human Case and a Murine Model

Annals of Neurology, EarlyView.
Narcolepsy type 1 is characterized by cataplexy, for which current treatments targeting monoaminergic, histaminergic, and GABAergic pathways may be ineffective or poorly tolerated. We report the case of a 34‐year‐old man with narcolepsy type 1, intolerant to standard therapies, who experienced marked and sustained cataplexy reduction with morning ...
Francois Ricordeau, Sebastien Arthaud, Leila Langbour, Silvia Melzi, Aurelie Richard‐Mornas, Hannah Doudoux, Benjamin Rolland, Laure Peter‐Derex, Christelle Peyron   +8 more
wiley   +1 more source

Effects of maternal separation on baseline sleep and cold stress-induced sleep rebound in adult Wistar rats

, 2004
Study Objectives: To evaluate the influence of early life environments on basal and cold stress-induced sleep patterns in rats.Design: The design was a 3 (Groups [control, early handling, maternal separation]) x 2 (Situations [basal, poststress]) x 11 ...
Sergio Tufik, Tufik, Sergio [UNIFESP], Suchecki, Deborah [UNIFESP], Tiba, Paula Ayako [UNIFESP], Deborah Suchecki, Paula Ayako Tiba   +5 more
core   +1 more source

Multimodal Characterization of Glymphatic‐Related Magnetic Resonance Imaging Markers in Huntington's Disease: A Multi‐Cohort Retrospective Study

Annals of Neurology, EarlyView.
Objective To characterize magnetic resonance imaging (MRI)‐based glymphatic surrogates in Huntington's disease (HD) using MRI measures of perivascular diffusivity and structural perivascular alterations across multiple large cohorts. Methods We analyzed 2,731 MRI sessions from 880 participants across 3 large retrospective HD cohorts.
Alexia Solomon, Zexi Wang, Francesco Sanvito, Zheng Zhou, Adys Mendizabal, Jingwen Yao   +5 more
wiley   +1 more source

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, EarlyView.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Fundamentals, Advances, and Applications of Electrospun Nanofibrous 3D Materials

Journal of Applied Polymer Science, EarlyView.
Three‐dimensional electrospun nanofibrous systems offer unique properties and microenvironments. These properties are determined by the fabrication strategies employed and can be adjusted by the incorporation of functional additives to achieve multifunctionality for specific applications. The applications range from the biomedical to the environmental,
Rebecca Hengsbach, Viraj P. Nirwan, Altangerel Amarjargal, Zahra Asefi, Amir Fahmi   +4 more
wiley   +1 more source

Sleep macro- and microstructure in migraine and cluster headache: a systematic review of objective assessments

The Journal of Headache and Pain
Background Patients with primary headache disorders including migraine and cluster headache often report poor sleep quality. While subjective reports of disturbed sleep are well established, the objective alterations in sleep architecture which occur in ...
Veronica Munday, Ellie Watson, Diana Y. Wei, Alexander D. Nesbitt, Peter J. Goadsby, Philip R. Holland, Ivana Rosenzweig   +6 more
doaj   +1 more source

A critical reappraisal of the carotid sinus and carotid bulb: Distinguishing neurohistological function from vascular geometry

The Anatomical Record, EarlyView.
This review redefines the carotid bulb (CB) as a variable geometric dilation shaped by hemodynamics and the carotid sinus (CS) as a conserved neurohistological baroreceptor field. Distinguishing these entities clarifies a century of anatomical confusion and links geometry, neurohistology, and clinical interpretation within a unified framework ...
Răzvan Costin Tudose, Nicolae Radu, Mugurel Constantin Rusu   +2 more
wiley   +1 more source

Description of large, well‐preserved Enchodus specimens from the Bearpaw Formation of Alberta, Canada

The Anatomical Record, EarlyView.
Abstract Fishes of the genus Enchodus were abundant and cosmopolitan in the Late Cretaceous, but are primarily known from isolated remains in Canada. Four well‐preserved fish skulls were recovered in recent years from ammolite mines sampling the Bearpaw Formation of Southern Alberta, and are here referred to Enchodus petrosus Cope, 1874.
Luke E. Nelson, Alison M. Murray, Donald B. Brinkman   +2 more
wiley   +1 more source

Lithium Prevents REM Sleep Deprivation-Induced Impairments on Memory Consolidation

, 2013
Background: Pre-training rapid eye movement sleep (REMS) deprivation affects memory acquisition and/or consolidation. It also produces major REMS rebound at the cost of waking and slow wave sleep (SWS). Given that both SWS and REMS appear to be important
Ota, Simone Marie [UNIFESP], Moreira, Karin Di Monteiro [UNIFESP], Suchecki, Deborah [UNIFESP], Tiba, Paula Ayako [UNIFESP], Oliveira, Maria Gabriela Menezes de [UNIFESP]   +4 more
core   +1 more source