Results 71 to 80 of about 703,277 (252)

Innovative Test Strip‐Based Colorimetric Sensors Integrated With Affinity Chromatography: Acetylcholinesterase Inhibitor Screening Breakthrough in Lycium Barbarum Leaves

Advanced Science, EarlyView.
Schematic diagrams illustrating the breakthrough in the screening of AChE inhibitors from LBL, and the research process of the pharmacodynamics of the NCP are presented. ABSTRACT Current Alzheimer's drugs exhibit limited effectiveness, highlighting the necessity for multi‐target treatments.
Yuping Sa, Hui Yuan, Jingui Ma, Zhigang Yang, Mei Wang, Weibiao Wang, Lingling Yang, Fen Ma, Weiman Zhang, Gidion Wilson Mening'oo, Guoning Chen, Xueqin Ma   +11 more
wiley   +1 more source

Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid‐Beta Pathology in Alzheimer's Mice

Advanced Science, EarlyView.
Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu, Jihua Fan, Xiang Zhou, Zhiqi Yang, Mingyue Gong, Mingzhu Huang, Zhenlu Cai, Shaofan Yang, Teng Teng, Chuanyan Yang, Jin Li, Haoyu Wang, Shuangshuang Dai, Chunhai Chen, Xiaowei Chen, Manxia Wang, Kuan Zhang   +16 more
wiley   +1 more source

Sleep During Pregnancy: The nuMoM2b Pregnancy and Sleep Duration and Continuity Study [PDF]

, 2017
To characterize sleep duration, timing and continuity measures in pregnancy and their association with key demographic variables. Multisite prospective cohort study.
Judette M. Louis, Judith H. Chung, Pien, Grace W., Francesca L. Facco, Wing, Deborah A., Kathryn J. Reid, Grace W. Pien, Jay Iams, Samuel Parry, Saade, George R, Haas, David M., Facco, Francesca L., Basner, Robert C, Zee, Phyllis C, Hyagriv N. Simhan, Reid, Kathryn J., Deborah A. Wing, Chung, Judith H, Grobman, William A, Robert C. Basner, Simhan, Hyagriv N., Simhan, Hyagriv N, Shalini Manchanda, Louis, Judette M., Basner, Robert C., Manchanda, Shalini, Saade, George R., Nhan-Chang, Chia-Lang, Phyllis C. Zee, Louis, Judette M, Herbas, Marcos, Marcos Herbas, Shannon Hunter, Hunter, Shannon, Parker, Corette B, David M. Haas, Chung, Judith H., George R. Saade, Chia-Lang Nhan-Chang, Wing, Deborah A, Facco, Francesca L, Robert M. Silver, Iams, Jay, Zee, Phyllis C., Parker, Corette B., Grobman, William A., Pien, Grace W, William A. Grobman, Corette B. Parker, Parry, Samuel, Reid, Kathryn J, Haas, David M, Silver, Robert M., Silver, Robert M   +53 more
core   +1 more source

Associations of actigraphy measures of sleep duration and continuity with executive function, vigilance, and fine motor control in children with snoring and mild sleep-disordered breathing

, 2023
Children with snoring and mild sleep-disordered breathing may be at increased risk for neurocognitive deficits despite few obstructive events. We hypothesized that actigraphy-based sleep duration and continuity associate with neurobehavioral functioning ...
Zhuoran Wei, Ron B. Mitchell, Fauziya Hassan, Keith A. Robinson, Hjelm, Michelle, Rueschman, Michael, Kamal Naqvi, Tham, Addy, Lisa M. Elden, Cristina M. Baldassari, Tapia, Ignacio E, Ievers-Landis, Carolyn E, Jerilynn Radcliffe, Hassan, Fauziya, Wang, Rui, Kirkham, Erin, Sally Ibrahim, Michelle Hjelm, Carol L. Rosen, Michael Rueschman, Ignacio E. Tapia, Naqvi, Kamal, Ariel A. Williamson, Addy Tham, Chervin, Ronald D, Ronald D. Chervin, Williamson, Ariel A, Ishman, Stacey, Wei, Zhuoran, Mitchell, Ron B, Rui Wang, Stacey Ishman, Erin Kirkham, Susan Garetz, Robinson, Keith A, Elden, Lisa M, Baldassari, Cristina M, Taylor, H Gerry, Susan Redline, Carolyn E. Ievers-Landis, H. Gerry Taylor, Rosen, Carol L, Ibrahim, Sally, Redline, Susan, Radcliffe, Jerilynn, Garetz, Susan   +45 more
core   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Different criteria of sleep latency and the effect of melatonin on sleep consolidation

, 2004
Objectives: Since there is no consensus definition of sleep onset, we studied different aspects of initial sleep periods in healthy volunteers taking melatonin.
Sergio Tufik, Luciano Ribeiro Pinto, Tufik, Sergio [UNIFESP], Maria de Lourdes Seabra, Pinto Júnior, Luciano Ribeiro [UNIFESP], Seabra, Maria de Lourdes [UNIFESP]   +5 more
core   +1 more source

Adaptive Conductive Systems: Enabling Deformable Electronics Through Engineered Materials, Circuits, and Intelligent Systems

Advanced Science, EarlyView.
This review presents the research advances of adaptive conductive systems from the perspective of materials, circuits, systems, and applications. Deformable conductors consist of substrates/matrices and conductive materials, structural design of circuit interconnections, fabrication of circuit interconnections, as well as intelligent systems ...
Yufei Lu, Siyu Liang, Jingyi Niu, Jie Chen, Shuo Zhang, Hongjian Zhang, Dongsheng Jia, Wei Huang   +7 more
wiley   +1 more source

In-Home Sleep Recordings in Military Veterans With Posttraumatic Stress Disorder Reveal Less REM and Deep Sleep <1 Hz

Frontiers in Human Neuroscience, 2018
Veterans with posttraumatic stress disorder (PTSD) often report suboptimal sleep quality, often described as lack of restfulness for unknown reasons. These experiences are sometimes difficult to objectively quantify in sleep lab assessments.
Julie A. Onton, Julie A. Onton, Scott C. Matthews, Scott C. Matthews, Dae Y. Kang, Todd P. Coleman   +5 more
doaj   +1 more source

Sleep-related sweating in obstructive sleep apnoea: association with sleep stages and blood pressure

, 2010
To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldThe aim of this study was to investigate sleep-related sweating as a symptom of obstructive sleep apnoea (OSA).
Arnardottir, Erna S I F,, Gislason, Thorarinn,, Thorleifsdottir, Bjorg, Olafsson, Isleifur, Thorleifsdottir, Bjorg,, Olafsson, Isleifur,, Svanborg, Eva, Arnardottir, Erna Sif, Gislason, Thorarinn, Svanborg, Eva,   +9 more
core   +1 more source

Tumor Exposomics: A New Paradigm for Individualized Continuous Exposure Monitoring

Advanced Science, EarlyView.
Tumor exposomics integrates continuous monitoring of environmental exposures, endogenous biological responses, and behavioral factors within a unified temporal framework. By combining multimodal sensing technologies with AI‐enabled causal modeling, this emerging paradigm reconstructs exposure‐damage trajectories and supports individualized dynamic risk
Kaicheng Shen, Weiyi Wang, Yang Wang, Yiqiang Wu, Xiaohong Liu, Wei Zhang, Juanjuan Ou   +6 more
wiley   +1 more source