Results 31 to 40 of about 25,296 (269)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Prevalence and factors associated with sleep disorders among children with cerebral palsy in Uganda; a cross-sectional study [PDF]

, 2018
This study determined the prevalence and associated factors of sleep disorders among children aged 2 – 12 years with cerebral palsy in Uganda.Background Sleep plays a prominent role in the growth and development of children. Children with cerebral palsy
Munyumu, Kisughu, Kaddumukasa, Mark, Idro, Richard, Richard Idro, Elly Katabira, Abbo, Catherine, Mupere, Ezekiel, Ezekiel Mupere, Katabira, Elly, Angelina Kakooza-Mwesige, Mark Kaddumukasa, Kakooza-Mwesige, Angelina, Catherine Abbo, Kisughu Munyumu   +13 more
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

The adverse impact of excessive smartphone screen-time on sleep quality among young adults: A prospective cohort [PDF]

Sleep Science
Introduction: Problematic over usage of smartphones has led to various deteriorating effects including poor sleep quality. Screen exposure, especially near bedtime, directly leads to poor sleep quality.
Daneyal Arshad, Usaid Munir Joyia, Sadaf Fatima, Noor Khalid, Anser Ikram Rishi, Naimat Ullah Abdul Rahim, Syed Faheem Bukhari, Gulfam Khan Shairwani, Ahmed Salmaan   +8 more
doaj   +1 more source

Associations between menopausal hormone therapy and sleep disturbance in women during the menopausal transition and post-menopause: data from the Norwegian prescription database and the HUNT study

BMC Women's Health, 2020
Background Impaired sleep is common in menopausal women. The aim was to examine associations between uses of systemic menopausal hormone therapy (MHT) and sleep disturbance in a large population sample.
Randi Andenæs, Milada Cvancarova Småstuen, Nina Misvær, Lis Ribu, Ingvild Vistad, Sølvi Helseth   +5 more
doaj   +1 more source

Reliability and Validity of the Brief Insomnia Questionnaire in the America Insomnia Survey

, 2010
Study Objectives: To evaluate the reliability and validity of the Brief Insomnia Questionnaire (BIQ), a fully structured questionnaire developed to diagnose insomnia according to hierarchy-free Diagnostic and Statistical Manual, Fourth Edition, Text ...
Kessler, Ronald C., Shillington, Alicia, Walsh, James K., Coulouvrat, Catherine, Hajak, Goeran, Zammit, Gary K., Sampson, Nancy, Lakoma, Matthew D., Roth, Thomas, Stephenson, Judith J., Shahly, Victoria   +10 more
core   +1 more source

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Sleep disorders in children with cerebral palsy.

, 2006
To determine the frequency and predictors of sleep disorders in children with cerebral palsy (CP) we analyzed the responses of 173 parents who had completed the Sleep Disturbance Scale for Children.
Newman, C.J., Hensey, O., O'Regan, M.
core   +1 more source