Results 71 to 80 of about 22,100 (204)

Precision‐Arranged DNA Origami Plasmonic Nanoantennas for Multidimensional Smart‐Warning of Weightlessness Induced Bone Loss

Advanced Science, EarlyView.
It is synthesized precision‐arranged DNA origami plasmonic nanoantennas for multiplexed and intelligent warning of bone loss induced by microgravity and radiation. The ordered nanoantennas simultaneously and accurately detected calcium ions, interleukin‐6, and microRNA‐214 in serum from mice exposed to microgravity and radiation, with performance ...
Yufan Ling, Xuan Qin, Weijia Sun, Fan Yue, Yiwei Wang, Di Fan, Haoyuan Xu, Ruao Xie, Jiawei Zhang, Jianwei Li, Bingyan Li, Yang Yang, Yingxian Li, Houyu Wang, Guangming Zhou   +14 more
wiley   +1 more source

Targeting Histamine H4 Receptor in the Rostral Ventromedial Medulla to Relieve Hypertension

Advanced Science, EarlyView.
H4R and its downstream TRPV1 channel mediate the excitatory effect of TMN histaminergic afferent inputs on GABAergic sympathoinhibitory neurons in RVMM. Intranasal delivery of selective H4R agonist VUF 8430 suppresses renal sympathetic outflow and elicits sustained depressor and bradycardia responses in SHRs and CUMS‐induced hypertensive rats ...
Ying Shi, Yang‐Xun Zhang, Jun‐Yi Chen, Sai Ma, Wei‐Xuan Xue, Wei Li, Qian‐Xiao Li, Bo Song, Ya‐Ting Li, Hong‐Yu Ma, Shu‐Tao Xie, Hong‐Zhao Li, Di‐Jun Chen, Qi‐Peng Zhang, Hui‐Jie Ma, Jian‐Jun Wang, Lei Yu, Xiao‐Yang Zhang, Jing‐Ning Zhu   +18 more
wiley   +1 more source

Type 2 Diabetes‐Associated Phenylacetylglutamine Induces Deleterious Inflammation Cycle in Myeloid Cells through β2 Adrenergic Receptors and Impedes Wound Healing

Advanced Science, EarlyView.
The microbiota‐derived metabolite phenylacetylglutamine (PAGln) is elevated in type 2 diabetes and tightly associated with poor healing in both diabetic and non‐diabetic human patients. PAGln promotes mouse inflammation and impairs healing through a transmissible β2‐adrenergic receptor–mediated trained‐immunity loop.
Lu Huang, Xinran Ye, Chia‐Kang Ho, Ya Gao, Dongsheng Wen, Jiaming Sun, Yuxin Liu, Yangdan Liu, Guoyuan Wang, Yangbai Sun, Jinyan Zhang, Yifan Zhang, Qingfeng Li   +12 more
wiley   +1 more source

Polydopamine Nanodots Ameliorate Inflammatory Bowel Disease by Restoring Redox Homeostasis and Intestinal Microenvironment

Advanced Science, EarlyView.
A novel melanin‐based therapeutic composed of ultrasmall polydopamine nanodots is employed as an efficient oral formulation for the targeted treatment of inflammatory bowel disease. The potential therapeutic mechanism of polydopamine nanodots mainly involves the elimination of excessive oxidative stress, the reduction of ROS‐mediated proinflammatory ...
Zhen Ding, Xingfu Bao, Ying Zhao, Lin Bai, Jinming Zhang, Chengjing Xu, Tianyan Chen, Shuang Dai, Yufu Liu, Min Hu, Meng Qin, Zhen Liu   +11 more
wiley   +1 more source

Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review

Advanced Science, EarlyView.
Recent advances in materials and device engineering enable continuous, real‐time monitoring of muscle activity via wearable and implantable systems. This review critically summarizes emerging technologies for tracking electrophysiological, biomechanical, and oxygenation signals, outlines fundamental principles, and highlights key challenges and ...
Zhengwei Liao, Ata Golparvar, Mohammad Javad Bathaei, Filipe Arroyo Cardoso, Clementine M. Boutry   +4 more
wiley   +1 more source

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

Overview of clinical trial protocols for behavioral insomnia in infants

Revista Brasileira de Enfermagem
Objective: to describe the overview of clinical trial protocols for behavioral insomnia in infants. Methods: an analytical study that reviewed protocols registered with the International Clinical Trials Registry Platform between August and September ...
Rayanne Branco dos Santos Lima, Ana Jéssica Lopes Dias, Lorena Pinheiro Barbosa   +2 more
doaj   +2 more sources

Comparing the Effects of Melatonin and Zolpidem on Sleep Quality, Depression, and Anxiety in Patients With Colorectal Cancer Undergoing Chemotherapy

Basic and Clinical Neuroscience, 2021
Introduction: Patients with cancer may have many complications involving their psychosomatic systems, such as sleep disturbance, depression, and anxiety. Thus, many research studies were conducted to reduce these complications.
Maryam Shahrokhi, Padideh Ghaeli, Pantea Arya, Alia Shakiba, Afsaneh Noormandi, Mehdi Soleimani, Mohsen Esfandbod   +6 more
doaj  

Enhanced Selenium Supplement Extends Lifespan and Delays Multi‐Organs Aging by Regulating the Sik1 Pathway Through Maintaining Calcium Homeostasis

Advanced Science, EarlyView.
Aging involves physiological decline and heightened disease susceptibility, necessitating effective interventions. Redox‐responsive selenium‐loaded nanoparticles (SeMSNs) are developed, which delay cellular senescence by reducing oxidative stress and senescence markers (p16/p21). In aged mice, SeMSNs extend lifespan, improve organ function, and restore
Yang Yu, Jintao Song, Mengjiao Guo, RuZe Ma, Mingyang Du, Zhe Xun, Xu Liu, RongXia Xu, Xiaochun Xie, Peilin Qi, Yujie Chen, Dan Shao, Chao Yang, Liang Wang, Xiaoyu Song, Difei Wang   +15 more
wiley   +1 more source

Strain‐Adaptive Liquid Metal Interfaces Overcome Poisson's Ratio Constraints in Piezoresistive Sensors for Infant Sleep Monitoring

Advanced Science, EarlyView.
 This work overcomes Poisson's ratio limitations in piezoresistive sensors via strain‐adaptive liquid metal (LM) interfaces. EGaIn‐coated TPU scaffolds enable directional LM flow to fill microcracks under deformation, achieving ultra‐high sensitivity (693.65 kPa-1).
Yuxiao Zhang, Chenchen Wang, Juan Tao, Shaoyu Ma, Siyu Xie, Weiwei Guo, Rongrong Bao, Jianbei Qiu, Yue Liu, Zhengwen Yang, Caofeng Pan   +10 more
wiley   +1 more source