Results 61 to 70 of about 1,213,978 (351)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Effect of physical exercise on sleep quality in college students: Mediating role of smartphone use.

PLoS ONE, 2023
ObjectiveTo investigate the effect of physical exercise on sleep quality and the mediating effect of smartphone use behavior in college students.MethodsA cross-sectional study design was adopted.
Chuan-Yi Xu, Kai-Tuo Zhu, Xiang-Yan Ruan, Xiao-Ya Zhu, Yang-Sheng Zhang, Wen-Xia Tong, Bo Li   +6 more
doaj   +1 more source

Daily Sleep Quality is Associated with Daily Cognition in Late-Life [PDF]

, 2020
Background: Older adults often face sleep disturbance or cognitive decline that goes beyond the scope of normal aging. The present study examined the relationship between self-reported sleep quality and self-reported daytime attention in a community ...
Alessi, Cathy A., Donovan, Emily K., Dzierzewski, Joseph M., Fung, Constance H., Josephson, Karen R., Martin, Jennifer L.   +5 more
core   +1 more source

Polymorphisms in the circadian expressed genes PER3 and ARNTL2 are associated with diurnal preference and GNβ3 with sleep measures [PDF]

, 2014
Sleep and circadian rhythms are intrinsically linked, with several sleep traits, including sleep timing and duration, influenced by both sleep homeostasis and the circadian phase.
Archer, Simon N, Barclay, Nicola L, Eley, Thalia C, Gregory, Alice M, Lester, Kathryn J, Nolan, Patrick M, Parsons, Michael J   +6 more
core   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Objective sleep quality predicts subjective sleep ratings

Scientific Reports
Abstract In both clinical and observational studies, sleep quality is usually assessed by subjective self-report. The literature is mixed about how accurately these self-reports track objectively (e.g. via polysomnography) assessed sleep quality, with frequent reports of little to no association.
Róbert Pierson-Bartel, Péter Przemyslaw Ujma   +1 more
openaire   +3 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

The relationship between sleep status and activity of daily living: based on China Hainan centenarians cohort study

BMC Geriatrics, 2023
Objective This study, based on the China Hainan Centenarians Cohort Study (CHCCS), aims to comprehensively describe the characteristic of daytime, night and total sleep duration, sleep quality and different sleep mode of Hainan centenarians and their ...
Shanshan Yang, Shengshu Wang, Guangdong Liu, Rongrong Li, Xuehang Li, Shimin Chen, Yali Zhao, Miao Liu, Yunxi Liu, Yao He   +9 more
doaj   +1 more source

Associations between diurnal preference, sleep quality and externalizing behaviours: a behavioural genetic analysis [PDF]

, 2010
Background - Certain aspects of sleep co-occur with externalizing behaviours in youth, yet little is known about these associations in adults. The present study: (1) examines the associations between diurnal preference (morningness versus eveningness ...
Barclay, Nicola, Eley, Thalia, Gregory, Alice, Maughan, Barbara, Rowe, Richard   +4 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source