Results 51 to 60 of about 148,565 (284)

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

A Systematic Review of Sleep–Wake Disorder Diagnostic Criteria Reliability Studies

Biomedicines, 2022
The aim of this article is to provide a systematic review of reliability studies of the sleep–wake disorder diagnostic criteria of the international classifications used in sleep medicine. Electronic databases (ubMed (1946–2021) and Web of Science (—2021)
Christophe Gauld, Régis Lopez, Pierre Philip, Jacques Taillard, Charles M. Morin, Pierre Alexis Geoffroy, Jean-Arthur Micoulaud-Franchi   +6 more
doaj   +1 more source

The sleep cycle: a mathematical analysis from a global workspace perspective [PDF]

, 2005
Dretske's technique of invoking necessary conditions from information theory to describe mental process can be used to derive a version of Hobson's AIM treatment of the sleep/wake cycle from a mathematical formulation of Baars' Global Workspace model of ...
Wallace, Rodrick
core  

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Development and validation of the Japanese version of the Bedtime Procrastination Scale (BPS-J)

BMC Psychology
Background The average sleep duration of Japanese people is shorter than that of people from other countries, and bedtime procrastination is suspected to be one of the factors contributing to this issue.
Megumi Hazumi, Aoi Kawamura, Takuya Yoshiike, Kentaro Matsui, Shingo Kitamura, Ayumi Tsuru, Kentaro Nagao, Naoko Ayabe, Tomohiro Utsumi, Muneto Izuhara, Mio Shinozaki, Eriya Takahashi, Michio Fukumizu, Momo Fushimi, Satomi Okabe, Taisuke Eto, Daisuke Nishi, Kenichi Kuriyama   +17 more
doaj   +1 more source

Abnormal Growth and Feeding Behavior Persist After Removal of Upper Airway Obstruction in Juvenile Rats

Scientific Reports, 2017
Pediatric obstructive sleep-disordered breathing is associated with growth retardation, but also with obesity that has a tendency to persist following treatment. We investigated the effect of upper airways obstruction (AO) and of obstruction removal (OR)
Mohammad H. Assadi, Elena Shknevsky, Yael Segev, Ariel Tarasiuk   +3 more
doaj   +1 more source

Insights into the Frequency and Distinguishing Features of Sleep Disorders in Pediatric Palliative Care Incorporating a Systematic Sleep Protocol

Children, 2021
Currently, no concrete figures on sleep disorders and sleep characteristics in children and adolescents with life-limiting conditions (LLC) and severe neurological impairment (SNI) based on pediatric palliative care professionals’ assessment and ...
Larissa Alice Dreier, Boris Zernikow, Kathrin Stening, Julia Wager   +3 more
doaj   +1 more source

Solving the mystery of human sleep schedules one mutation at a time. [PDF]

, 2013
Sleep behavior remains one of the most enigmatic areas of life. The unanswered questions range from "why do we sleep?" to "how we can improve sleep in today's society?" Identification of mutations responsible for altered circadian regulation of human ...
Fu, Ying-Hui, Hallows, William C, Ptáček, Louis J   +2 more
core   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Time-Restricted Feeding Improves Circadian Dysfunction as well as Motor Symptoms in the Q175 Mouse Model of Huntington's Disease. [PDF]

, 2018
Huntington's disease (HD) patients suffer from a progressive neurodegeneration that results in cognitive, psychiatric, cardiovascular, and motor dysfunction.
Colwell, Christopher S, Cutler, Tamara, Howland, David, Loh, Dawn H, Wang, Huei-Bin, Whittaker, Daniel S   +5 more
core   +1 more source