Results 131 to 140 of about 707,629 (374)
Crystal structures of trypanosoma brucei oligopeptidase B broaden the paradigm of catalytic regulation in prolyl oligopeptidase family enzymes [PDF]
Oligopeptidase B cleaves after basic amino acids in peptides up to 30 residues. As a virulence factor in bacteria and trypanosomatid pathogens that is absent in higher eukaryotes, this is a promising drug target.
Canning, Peter+3 more
core +3 more sources
ABSTRACT Women with the FMR1 premutation (FXpm) are at heightened genetic vulnerability for depression, with risk compounded by the stressors of parenting a disabled child. Although risk factors persist as FXpm women age, depression in FXpm mothers during midlife and old age is poorly characterized. This study used an accelerated longitudinal design to
Jessica Klusek+8 more
wiley +1 more source
Epidemiology of Trypanosoma brucei rhodesiense sleeping sickness in Eastern Uganda [PDF]
Sleeping sickness is now recognized as one of the recent re-emerging but neglected diseases. In Uganda and the rest of sub-Saharan Africa, old foci of sleeping sickness persist despite donor-funded projects and there is evidence of expansion of these ...
Odiit, Martin.
core +1 more source
Counterflow dielectrophoresis for trypanosome enrichment and detection in blood [PDF]
Human African trypanosomiasis or sleeping sickness is a deadly disease endemic in sub-Saharan Africa, caused by single-celled protozoan parasites. Although it has been targeted for elimination by 2020, this will only be realized if diagnosis can be ...
A Carlsson+19 more
core +1 more source
Genetics of Response to ECT, TMS, Ketamine and Esketamine
ABSTRACT Treatment‐resistant mood disorders are often managed with intensive interventions that include electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), ketamine, and esketamine, but the role of genetics in clinical response to those interventions is yet to be clearly determined.
Clio E. Franklin+18 more
wiley +1 more source
ABSTRACT Mental disorders are a significant global public health concern, affecting nearly one in eight individuals worldwide. This review investigates the multifaceted etiology of mental disorders—specifically major depressive disorder (MDD), schizophrenia (SCZ), and bipolar disorder (BD)—through genetic, neurobiological, and environmental ...
Maria Francesca Astorino+8 more
wiley +1 more source
Updated estimate of the duration of the meningo-encephalitic stage in gambiense human African trypanosomiasis [PDF]
Background: The duration of the stages of HAT is an important factor in epidemiological studies and intervention planning. Previously, we published estimates of the duration of the haemo-lymphatic stage 1 and meningo-encephalitic stage 2 of the ...
Chandramohan, Daniel+4 more
core +2 more sources
A Clinical Lecture on the Sleeping Sickness: Delivered at Charing Cross Hospital, October, 1898 [PDF]
Patrick Manson
openalex +1 more source
Background Uganda has active foci of both chronic and acute HAT with the acute zoonotic form of disease classically considered to be restricted to southeast Uganda, while the focus of the chronic form of HAT was confined to the northwest of the country ...
B. von Wissmann+5 more
semanticscholar +1 more source