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2009
Sleeping sickness or African trypanosomiasis is caused by the extracellular parasite. Trypanosoma brucei and is lethal if untreated. The encephalitic stage is characterized by disrupted sleep pattern, with sleep episodes during the day and wakefulness during the night.
Kristensson K. +1 more
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Sleeping sickness or African trypanosomiasis is caused by the extracellular parasite. Trypanosoma brucei and is lethal if untreated. The encephalitic stage is characterized by disrupted sleep pattern, with sleep episodes during the day and wakefulness during the night.
Kristensson K. +1 more
openaire +3 more sources
The pathogenesis of sleeping sickness
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1980Although the clinical and pathological features of sleeping sickness have been well recognized since the beginning of the century, we still have very little idea about how these changes are brought about. A convincing role for a trypanosome-derived toxin has yet to be established and it is probable that most tissue damage results from an ...
H.C. Whittle, B.M. Greenwood
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Vector Borne and Zoonotic Diseases, 2019
In 2005, the zoonotic acute sleeping sickness was spreading rapidly from the endemic areas of southeastern Uganda with potential for merger into areas affected by the chronic form of the disease in northwest Uganda.
C. Waiswa, Mandela Robert Wangoola
semanticscholar +1 more source
In 2005, the zoonotic acute sleeping sickness was spreading rapidly from the endemic areas of southeastern Uganda with potential for merger into areas affected by the chronic form of the disease in northwest Uganda.
C. Waiswa, Mandela Robert Wangoola
semanticscholar +1 more source
Sleeping sickness and the brain
Cellular and Molecular Life Sciences, 2002Recent progress in understanding the neuropathological mechanisms of sleeping sickness reveals a complex relationship between the trypanosome parasite that causes this disease and the host nervous system. The pathology of late-stage sleeping sickness, in which the central nervous system is involved, is complicated and is associated with disturbances in
Richard Burchmore +3 more
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Neurobiology of sleeping sickness
Parasitology Today, 1989The advanced stages of sleeping sickness are correlated with a spread of trypanosomes into the central nervous system (CNS), producing a disseminated encephalitis. Inflammatory reactions extend along the blood vessels causing perivascular cuffing, which consists of in filtrations and proliferations of lymphocytes and also increased numbers of ...
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The duality of sleeping sickness: focusing on sleep
Sleep Medicine Reviews, 2001Sleeping sickness, once under control, is a re-emergent endemic parasitic disease in intertropical Africa. Its originality resides in its duality. Two trypanosome groups (Trypanososma brucei gambiense vs.rhodesiense ) are transmitted to humans by tsetse flies from two geographical areas (Western and Central Africa humid forest vs.
Radomski Mw +6 more
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Sleeping Sickness in the ‘Omics Era
PROTEOMICS – Clinical Applications, 2018AbstractSleeping sickness is a neglected tropical disease caused by Trypanosoma brucei parasites, affecting the poorest communities in sub‐Saharan Africa. The great efforts done by the scientific community, local governments, and non‐governmental organizations (NGOs) via active patients’ screening, vector control, and introduction of improved treatment
Tiberti, Natalia, Sanchez, Jean-Charles
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Sleeping Sickness Surveillance In The Abraka Sleeping Sickness Focus, Nigeria
Annals of Biomedical Sciences, 2008Humans are the main reservoir hosts for gambiense sleeping sickness. They are therefore essential for the sustainance of its endemicity and reemergence of epidemics in many disease foci within sub- Saharan Africa. To investigate the epidemiological and clinical significance of reservoir hosts in the Abraka Sleeping Sickness Focus (ASSF), this survey ...
L U Airauhi, K A Adesina, E A Airauhi
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Sleeping sickness: Sleep study of a case
Electroencephalography and Clinical Neurophysiology, 1970Abstract A 66-year-old patient with sleeping sickness was examined polygraphically 9 times in 4 months. The first clinical symptoms of the disease had been observed 4 years previously. Throughout the study period wakefulness and rapid eye movement sleep (REMS) were always normal while slow wave sleep (SWS) and intermediate sleep (Int. S) were always
B.A Schwartz, C Escande
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Nature Reviews Immunology, 2019
A new study in Science identifies nemuri (nur) as encoding a secreted factor in Drosophila that has both antimicrobial and sleep-inducing properties, thus providing a direct link between sleep homeostasis and the response to infection.
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A new study in Science identifies nemuri (nur) as encoding a secreted factor in Drosophila that has both antimicrobial and sleep-inducing properties, thus providing a direct link between sleep homeostasis and the response to infection.
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