Results 71 to 80 of about 268,175 (305)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

The Fourier Transform of Restrictions of Functions on the Slice

open access: yesCoRR, 2021
This paper considers the Fourier transform over the slice of the Boolean hypercube. We prove a relationship between the Fourier coefficients of a function over the slice, and the Fourier coefficients of its restrictions. As an application, we prove a Goldreich-Levin theorem for functions on the slice based on the Kushilevitz-Mansour algorithm for the ...
openaire   +2 more sources

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

open access: yesFEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura   +19 more
wiley   +1 more source

RapidSCAT Slice Spatial Response Function Contour Parameterization [PDF]

open access: yes, 2016
The spatial response function (SRF) of the backscatter measurements for a radar scatterometer is often used in reconstruction. It has been found that in many cases the SRF can be approximated as a binary function that is 1 inside the - 6 dB contour of ...
Niedfeldt, John Clyde
core  

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

open access: yesFEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta   +7 more
wiley   +1 more source

Reducing Power of BLAKE3 implementations with dedicated FPGA resources [PDF]

open access: yesInternational Journal of Electronics and Telecommunications
The BLAKE cryptographic hash functions are efficiently expressed in software; however, their hardware implementations do not match the speed and power efficiency of alternative methods.
Jarosław Sugier
doaj   +1 more source

Organotypic Brain Slice Culture Microglia Exhibit Molecular Similarity to Acutely-Isolated Adult Microglia and Provide a Platform to Study Neuroinflammation

open access: yesFrontiers in Cellular Neuroscience, 2020
Microglia are central nervous system (CNS) resident immune cells that have been implicated in neuroinflammatory pathogenesis of a variety of neurological conditions.
Alex R. D. Delbridge   +19 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

open access: yesFEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin   +12 more
wiley   +1 more source

Twistor interpretation of slice regular functions

open access: yes, 2018
Given a slice regular function f:Ω⊂H→H, with Ω∩R≠∅, it is possible to lift it to surfaces in the twistor space CP3 of S4≃H∪{∞} (see Gentili et al., 2014).
Amedeo Altavilla, Altavilla A.
core   +1 more source

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