Myogenic Fusogen‐Engineered Lipid Nanoparticles Enhance mRNA Delivery in Skeletal Muscle
This study reports a biomimetic strategy of engineering full‐length Myomaker, a muscle‐specific fusogen, into lipid nanoparticles (LNPs) to harness the native myoblast fusion capability for skeletal muscle mRNA delivery. The resulting Mymk‐LNPs enhance transfection in differentiating myocytes and enable Cre‐mediated reporter activation in injured ...
Fangyu Zhang +18 more
wiley +1 more source
Clinical Utility of Anti-reflux Mucosal Intervention for Refractory Gastroesophageal Reflux Disease in Patients With a Hiatal Hernia. [PDF]
Saino M +12 more
europepmc +1 more source
Here, we develop a high‐throughput algorithm that accelerates the elucidation of phase diagrams of topological spin textures using limited computational resources at high numerical accuracy. Applying this framework to the van der Waals magnet CrSBr, we unveiled a hierarchy of previously unknown topological textures (domain‐wall bimerons, bimeron chains,
Andrew Lyall +4 more
wiley +1 more source
Effect of Different PTFE Coatings Applied to 18CrNiMo7-6 Steel on the Coefficient of Friction and Wear Under Dry Sliding Contact Using the Ball-on-Disk Method at Different Loads. [PDF]
Krbata M +9 more
europepmc +1 more source
Genetically Programmed Shape‐Morphing of Engineered Living Materials
Here, bacterial and mammalian engineered living materials (ELMs) are presented, in which living cells direct genetically programmed and enzymatically mediated shape‐morphing. The resulting deformation and shape‐recovery can be actuated in a genetically controlled manner by an ELM incorporating out‐of‐equilibrium counteracting biochemical reactions with
Jan Becker +7 more
wiley +1 more source
Sliding metasurface for wide-angle beam steering with sharp frequency filtering. [PDF]
Shi H +6 more
europepmc +1 more source
Bioinspired Hydrogels with Broadly Programmable Mechanics for Soft‐Tissue Interfaces
Sea cucumber‐inspired gelatin hydrogels are formed by directional freezing and mechanically programmed through subsequent ionic treatment. Multiscale characterization and modeling link ion‐regulated chain interactions to directional load transfer within the aligned hierarchical architecture.
Youchao Teng +20 more
wiley +1 more source
A vibration control method for chatter mitigation in milling process based on sliding mode control and reinforcement learning. [PDF]
Paul S.
europepmc +1 more source
Mask‐encoded UV exposure translates digital color information into pixel‐resolved structural‐color patterns in hydroxypropyl cellulose gels. Gaussian‐process‐guided calibration links UV processing conditions, wavelength, and mask opacity, enabling parallel fabrication of multicolor images in a single 10 s exposure.
Mengting Ye +8 more
wiley +1 more source
Tribocorrosion Mechanisms of Inconel<sup>®</sup> 718 Under Intermittent Sliding in Alkaline Environment. [PDF]
Kowalski M +6 more
europepmc +1 more source

