Results 51 to 60 of about 11,486,483 (290)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Application of moving sliding mode control for a DC motor driven four-bar mechanism

Advances in Mechanical Engineering, 2018
The angular velocity of the input link of a mechanism fluctuates due to the inertia of links and the external forces, although it is generally assumed constant in design.
Orhan Çakar, Alper Kadir Tanyıldızı
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Improved control strategy for PMSM based on fuzzy sliding mode control and sliding-mode observer

Journal of Measurement Science and Instrumentation, 2021
Aimed at the problems of large torque ripple,obvious chattering and poor estimation accuracy of back-EMFs in traditional permanent magnet synchronous motor（PMSM）control system with sliding mode observer（SMO）,an improved control strategy for PMSM based on
ZHAO Feng, LUO Wen, GAO Fengyang, YU Jiale   +3 more
doaj  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Integral Sliding Mode and Integral Supertwisting Sliding Mode Control for Ship Course-Keeping

IEEE Access
This paper proposes variable structure-based nonlinear control algorithms, including synergetic, terminal synergetic, integral sliding mode, and integral supertwisting sliding mode controllers, for ship course-keeping.
Muhammad Munir Butt, Azhar Iqbal Kashif Butt, Iftikhar Ahmad   +2 more
doaj   +1 more source

New approach of sliding mode control for nonlinear uncertain pneumatic artificial muscle manipulator enhanced with adaptive fuzzy estimator

International Journal of Advanced Robotic Systems, 2018
A new enhanced adaptive fuzzy sliding mode control approach is proposed in this article with its good availability for application in control of a highly uncertain nonlinear two-link pneumatic artificial muscle manipulator. Stability demonstration of the
Ho Pham Huy Anh, Cao Van Kien, Nguyen Ngoc Son, Nguyen Thanh Nam   +3 more
doaj   +1 more source

On the notion of Safe Sliding Mode Control

Nonlinear Analysis: Hybrid Systems
12 pages, 7 ...
Marco A. Gómez, Christopher D. Cruz-Ancona, Leonid M. Fridman   +2 more
openaire   +3 more sources

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Fixed-Time-Convergent Sliding Mode Control with Sliding Mode Observer for PMSM Speed Regulation

Sensors
This paper focuses on the speed control of a permanent magnet synchronous motor (PMSM) for electric drives with model uncertainties and external disturbances.
Xin Zhang, Hongwen Li, Meng Shao
doaj   +1 more source