Results 51 to 60 of about 13,293,543 (349)

Surface morphology in engineering applications: Influence of roughness on sliding and wear in dry fretting [PDF]

, 2011
Influence of initial surface roughness on friction and wear processes under fretting conditions was investigated experimentally. Rough surfaces (Ra=0.15-2.52 [mu]m) were prepared on two materials: carbon alloy (AISI 1034) and titanium alloy (Ti-6Al-4V ...
Mathia, T.G., Kubiak, KJ, Kubiak, Krzysztof, Liskiewicz, T.W., K.J. Kubiak, T.G. Mathia, Mathia, TG, T.W. Liskiewicz, Liskiewicz, TW   +8 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Predicting UHMWPE wear: decreasing wear rate following a change in sliding direction [PDF]

, 2010
The patient demographic for total joint replacement is becoming younger and more active leading to increased performance expectations [1]. To develop new products that meet these demands, computer simulations that predict wear are emerging as potential ...
Taylor, M., Dressler, M.R., Schlacter, A.J., Ernsberger, C., Ross, M.A., Strickland, A.M.   +5 more
core  

Predicting implant UHMWPE wear in-silico: A robust, adaptable computational-numerical framework for future theoretical models [PDF]

, 2011
Computational methods for the pre-clinical wear prediction for devices such as hip, knee or spinal implants are valuable both to industry and academia. Archard’s wear model laid the basis for the first generation of theoretical wear estimation algorithms,
M.A. Strickland, Taylor, M., Strickland, M.A., M.R. Dressler, Dressler, M.R., M. Taylor   +5 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Sliding wear of nitrided steels [PDF]

, 1993
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The unlubricated sliding wear behaviour of gas nitrided, plasma nitrided, and ferritic nitrocarburized BS970,905M39 (EN41B) steels was investigated ...
Kato, Hirotaka, Kato, H
core  

A micromechanics investigation of sliding wear in coated components [PDF]

, 2000
In this work, the wear behaviour of coated components subjected to sliding contact conditions is investigated using a multiscale micromechanics approach.
Wenyi Yan, Esteban P. Busso, Esteban P. Bus so, Noel P. O'Dowd, Yan, Wenyi, Noel P. O’dowd, O'Dowd, Noel P., Busso, Esteban P.   +7 more
core   +1 more source

Statistical modeling of Si-based refractory compounds of bamboo leaf and alumina reinforced Al–Si–Mg alloy hybrid composites

Scientific Reports, 2023
Wear properties of Al–Mg–Si alloy matrix hybrid composites made with Si-based refractory compounds (SBRC) derived from bamboo leaf ash (BLA) as complimentary reinforcement with alumina have been studied. The experimental result indicate that optimum wear
Olanrewaju S. Adesina, Adeolu A. Adediran, Francis O. Edoziuno, Olufemi O. Sanyaolu, Babatunde A. Obadele   +4 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source