Results 71 to 80 of about 13,293,543 (349)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Wear Investigation of Aluminum Alloy Surface Layers Fabricated through Friction Stir Welding Method

Advances in Materials Science and Engineering, 2022
In this research paper, an effort was made to investigate the dry sliding wear rate of friction stir welded AA6262/AA5456 composite performed by the Taguchi approach. Wear experiments are carried out by selecting suitable process parameters such as load (
S. Vijayakumar, S. Anitha, R. Arivazhagan, Ashebir Dingeto Hailu, T. V. Janardhana Rao, Hari Prasadarao Pydi   +5 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Computational Analysis of Wall Slip and Cavitation in Lubricated Sliding Systems [PDF]

, 2012
Lubrication is applied to systems in which parts are in relative motion to avoid direct contact between the surfaces. The behavior of the fluid-film in sliding bearings depends on the boundary conditions at the interface between the liquid and the ...
M, Muchammad, D.J. , Schipper, J. , Jamari, M. , Tauviqirrahman   +3 more
core  

Online automatic tuning and control for fed-batch cultivation [PDF]

, 2007
Performance of controllers applied in biotechnological production is often below expectation. Online automatic tuning has the capability to improve control performance by adjusting control parameters.
Straten, G., van, Leo A. van der Pol, Anton J. B. van Boxtel, Boxtel, A.J.B., van, Pol, L.A., van der, Zita I. T. A. Soons, Soons, Z.I.T.A., Gerrit van Straten   +7 more
core   +1 more source

Investigating the tribological characteristics of copper surface composites reinforced with high entropy alloy (AlCoCrCuFe) through friction stir processing

Scientific Reports, 2023
The present investigation focuses on the fabrication of Copper-High Entropy Alloy (HEA) surface Metal Matrix Composite (MMC) using the solid-state Friction Stir Process (FSP) and the characterization of wear characteristics. Higher hardness values at the
Seenivasan Soundararajan, Gopal Pudhupalayam Muthukutti, Soorya Prakash Kumarasamy, Kavimani Vijayananth, Debabrata Barik, Prabhakar Sharma, Prabhu Paramasivam   +6 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Analysis of Sliding Characteristic of Traction Drive Reducer for Automotive In-wheel Motor

Jixie chuandong, 2018
To analyze the sliding characteristic of the traction drive reducer for the automotive in-wheel motor,the working mechanism is researched. Then,a mathematical model and an analysis method are proposed to accurately calculate the sliding characteristics ...
Shu Hongyu, Yao Zejie
doaj  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source