Results 1 to 10 of about 17,745 (295)

Comparative Analysis of Structural Features in SLiMs from Eukaryotes, Bacteria, and Viruses with Importance for Host-Pathogen Interactions

Pathogens, 2022
Protein-protein interactions drive functions in eukaryotes that can be described by short linear motifs (SLiMs). Conservation of SLiMs help illuminate functional SLiMs in eukaryotic protein families. However, the simplicity of eukaryotic SLiMs makes them
Jessica Siltberg-Liberles, Christian Balbin, Heidy Elkhaligy   +2 more
exaly   +3 more sources

Dynamic, but Not Necessarily Disordered, Human-Virus Interactions Mediated through SLiMs in Viral Proteins

Viruses, 2021
Most viruses have small genomes that encode proteins needed to perform essential enzymatic functions. Across virus families, primary enzyme functions are under functional constraint; however, secondary functions mediated by exposed protein surfaces that ...
Jessica Siltberg-Liberles, Jessica Gonzalez, Christian Balbin   +2 more
exaly   +3 more sources

Integrating AlphaFold2 models and clinical data to improve the assessment of Short Linear Motifs (SLiMs) and their variants' pathogenicity. [PDF]

PLoS Computational Biology
Short Linear Motifs (SLiMs) are protein functionally relevant regions that mediate reversible protein-protein interactions. Variants that disrupt SLiMs can lead to numerous Mendelian diseases.
Franco Gino Brunello, Lorenzo Erra, Juan Nicola, Marcelo Adrián Martí   +3 more
doaj   +2 more sources

The leader proteins of Theiler’s virus and Boone cardiovirus use a combination of short linear motifs (SLiMs) to target RSK kinases to the nuclear pore complex [PDF]

Journal of Virology
Unrelated pathogens, including viruses and bacteria, use a common short linear motif (SLiM) to interact with cellular kinases of the RSK (p90 S6 ribosomal kinase) family.
Belén Lizcano-Perret, Fanny Wavreil, Martin Veinstein, Camille Duflos, Romane Milcamps, Frédéric Sorgeloos, Thomas Michiels   +6 more
doaj   +2 more sources

Decoding phospho-regulation and flanking regions in autophagy-associated short linear motifs [PDF]

Communications Biology
Short Linear Motifs (SLiMs) play a pivotal role in the interactions between intrinsically disordered proteins and their binding partners. SLiMs can undergo regulation through post-translational modifications, including phosphorylation.
Mattia Utichi, Oana N. Antonescu, Valentina Sora, Henri-Baptiste Marjault, Matteo Tiberti, Emiliano Maiani, Matteo Lambrughi, Elena Papaleo   +7 more
doaj   +2 more sources

The Use of SLiMS in The Circle of School Librarians in Semarang City

Record and Library Journal, 2021
Background of the study: Utilization of technology at this time is urgently needed in a job. Library is one of the jobs that requires technology. The technology used in school libraries has several types, one of which is SLiMS.
Ario Adi Prakoso
doaj   +1 more source

Short Linear Motifs in Colorectal Cancer Interactome and Tumorigenesis

Cells, 2022
Colorectal tumorigenesis is driven by alterations in genes and proteins responsible for cancer initiation, progression, and invasion. This multistage process is based on a dense network of protein–protein interactions (PPIs) that become dysregulated as a
Candida Fasano, Valentina Grossi, Giovanna Forte, Cristiano Simone   +3 more
doaj   +1 more source

Assistance in Library Management Based on the Senayan Library Management System (SLiMS) at SMA Darut Taqwa Purwosari

Jurnal Soeropati, 2022
This community service program is carried out in the form of library management assistance based on SLiMS at Darut Taqwa High School, Purwosari Pasuruan. Libraries have an important role in building a learning community, as well as school libraries.
Hasan Syaiful Rizal, Jakfar Syodik, Mochamad Hasyim   +2 more
doaj   +1 more source

Pengaruh Sistem Informasi SLIMS Terhadap Manajemen Kemudahan Penggunaan Layanan di Perpustakaan IAIN Kediri

Journal of Islamic Education Management, 2020
Kemajuan teknologi khususnya di bidang IT pada saat ini berkembang cukup pesat. Salah satu manfaat yang didapatkan dari adanya perkembangan teknologi IT ini adalah adanya kemudahaan penggunaan dalam suatu sistem / unit.
Puspoko Ponco Ratno, Ana Ulin Nadhirin
doaj   +1 more source

A comparative study of short linear motif compositions of the influenza A virus ribonucleoproteins. [PDF]

PLoS ONE, 2012
Protein-protein interactions through short linear motifs (SLiMs) are an emerging concept that is different from interactions between globular domains. The SLiMs encode a functional interaction interface in a short (three to ten residues) poorly conserved
Chu-Wen Yang
doaj   +1 more source