Results 1 to 10 of about 237,743 (266)

Signatures of pleiotropy, economy and convergent evolution in a domain-resolved map of human-virus protein-protein interaction networks. [PDF]

PLoS Pathogens, 2013
A central challenge in host-pathogen systems biology is the elucidation of general, systems-level principles that distinguish host-pathogen interactions from within-host interactions.
Sara Garamszegi, Eric A Franzosa, Yu Xia
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Modeling EphB4-EphrinB2 protein–protein interaction using flexible docking of a short linear motif [PDF]

BioMedical Engineering OnLine, 2017
Background Many protein–protein interactions are mediated by a short linear motif. Usually, amino acid sequences of those motifs are known or can be predicted. It is much harder to experimentally characterize or predict their structure in the bound form.
Maciej Pawel Ciemny, Mateusz Kurcinski, Maciej Blaszczyk, Andrzej Kolinski, Sebastian Kmiecik   +4 more
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A comparative study of short linear motif compositions of the influenza A virus ribonucleoproteins. [PDF]

PLoS ONE, 2012
Protein-protein interactions through short linear motifs (SLiMs) are an emerging concept that is different from interactions between globular domains. The SLiMs encode a functional interaction interface in a short (three to ten residues) poorly conserved
Chu-Wen Yang
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Allosteric control of dynamin-related protein 1 through a disordered C-terminal Short Linear Motif [PDF]

Nature Communications
The mechanochemical GTPase dynamin-related protein 1 (Drp1) catalyzes mitochondrial and peroxisomal fission, but the regulatory mechanisms remain ambiguous.
Isabel Pérez-Jover, Kristy Rochon, Di Hu, Mukesh Mahajan, Pooja Madan Mohan, Isaac Santos-Pérez, Julene Ormaetxea Gisasola, Juan Manuel Martinez Galvez, Jon Agirre, Xin Qi, Jason A. Mears, Anna V. Shnyrova, Rajesh Ramachandran   +12 more
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A short linear motif in scaffold Nup145C connects Y-complex with pre-assembled outer ring Nup82 complex [PDF]

Nature Communications, 2017
The Nup82–Nup159–Nsp1 complex, which plays a key role in mRNA export, is recruited late during the process of nuclear pore complex (NPC) assembly. Here the authors combine crosslinking mass spectrometry, biochemical reconstitution and molecular modeling ...
Roman Teimer, Jan Kosinski, Alexander von Appen, Martin Beck, Ed Hurt   +4 more
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The predictive performance of short-linear motif features in the prediction of calmodulin-binding proteins [PDF]

BMC Bioinformatics, 2018
Background The prediction of calmodulin-binding (CaM-binding) proteins plays a very important role in the fields of biology and biochemistry, because the calmodulin protein binds and regulates a multitude of protein targets affecting different cellular ...
Yixun Li, Mina Maleki, Nicholas J. Carruthers, Paul M. Stemmer, Alioune Ngom, Luis Rueda   +5 more
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Short linear motif acquisition, exon formation and alternative splicing determine a pathway to diversity for NCoR-family co-repressors [PDF]

Open Biology, 2015
Vertebrate NCoR-family co-repressors play central roles in the timing of embryo and stem cell differentiation by repressing the activity of a range of transcription factors. They interact with nuclear receptors using short linear motifs (SLiMs) termed co-
Stephen Short, Tessa Peterkin, Matthew Guille, Roger Patient, Colin Sharpe   +4 more
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Replication licensing regulated by a short linear motif within an intrinsically disordered region of origin recognition complex [PDF]

Nature Communications
In eukaryotes, the origin recognition complex (ORC) faciliates the assembly of pre-replicative complex (pre-RC) at origin DNA for replication licensing.
Yue Wu, Qiongdan Zhang, Yuhan Lin, Wai Hei Lam, Yuanliang Zhai   +4 more
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Brucella NpeA is a secreted Type IV effector containing an N-WASP-binding short linear motif that promotes niche formation [PDF]

mBio
The modulation of actin polymerization is a common theme among microbial pathogens. Even though microorganisms show a wide repertoire of strategies to subvert the activity of actin, most of them converge in the ones that activate nucleating factors, such
Agostina Giménez, Mariela G. Del Giudice, Paula V. López, Francisco Guaimas, Hugo Sámano-Sánchez, Toby J. Gibson, Lucía B. Chemes, Carlos O. Arregui, Juan E. Ugalde, Cecilia Czibener   +9 more
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Elucidation of short linear motif-based interactions of the MIT and rhodanese domains of the ubiquitin-specific protease 8 [PDF]

Biology Direct
Ubiquitin-specific protease 8 (USP8) is a deubiquitinating enzyme with essential functions in protein trafficking and stability. It is a multidomain protein, with an N-terminal MIT (microtubule interacting and trafficking) domain, followed by a non ...
Aimiliani Konstantinou, Julia K. Varga, Alicia Córdova-Pérez, Leandro Simonetti, Lidia Gomez-Lucas, Ora Schueler-Furman, Norman E. Davey, Yogesh Kulathu, Ylva Ivarsson   +8 more
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