The calmodulin-binding, short linear motif, NSCaTE is conserved in L-type channel ancestors of vertebrate Cav1.2 and Cav1.3 channels. [PDF]
PLoS ONE, 2013 NSCaTE is a short linear motif of (xWxxx(I or L)xxxx), composed of residues with a high helix-forming propensity within a mostly disordered N-terminus that is conserved in L-type calcium channels from protostome invertebrates to humans.
Valentina Taiakina +6 more
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The "DDVF" motif used by viral and bacterial proteins to hijack RSK kinases mimics a short linear motif (SLiM) found in proteins related to the RAS-ERK MAP kinase pathway. [PDF]
PLoS PathogensProteins of pathogens such as cardioviruses, Kaposi sarcoma-associated herpes virus, varicella zoster virus and bacteria of the genus Yersinia were previously shown to use a common "DDVF" (D/E-D/E-V-F) short linear motif (SLiM) to hijack cellular kinases
Martin Veinstein +4 more
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Diversity of short linear interaction motifs in SARS-CoV-2 nucleocapsid protein
mBio, 2023 Molecular mimicry of short linear interaction motifs has emerged as a key mechanism for viral proteins binding host domains and hijacking host cell processes.
Peter Schuck, Huaying Zhao
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FOXP in Tetrapoda: Intrinsically Disordered Regions, Short Linear Motifs and their evolutionary significance [PDF]
Genetics and Molecular Biology, 2017 The FOXP subfamily is probably the most extensively characterized subfamily of the forkhead superfamily, playing important roles in development and homeostasis in vertebrates.
Lucas Henriques Viscardi +7 more
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Definition and Discovery of Tandem SH3-Binding Motifs Interacting with Members of the p47phox-Related Protein Family [PDF]
BiomoleculesSH3 domains are widespread protein modules that mostly bind to proline-rich short linear motifs (SLiMs). Most known SH3 domain-motif interactions and canonical or non-canonical recognition specificities are described for individual SH3 domains.
Zsofia E. Kalman +3 more
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Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications. [PDF]
Sci Signal, 2021 Mészáros B +10 more
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Redefining the BH3 Death Domain as a 'Short Linear Motif'. [PDF]
Trends Biochem Sci, 2015 B cell lymphoma-2 (BCL-2)-related proteins control programmed cell death through a complex network of protein-protein interactions mediated by BCL-2 homology 3 (BH3) domains. Given their roles as dynamic linchpins, the discovery of novel BH3-containing proteins has attracted considerable attention.
Aouacheria A +3 more
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Short Linear Motifs Characterizing Snake Venom and Mammalian Phospholipases A2 [PDF]
Toxins, 2021 Snake venom phospholipases A2 (PLA2s) have sequences and structures very similar to those of mammalian group I and II secretory PLA2s, but they possess many toxic properties, ranging from the inhibition of coagulation to the blockage of nerve transmission, and the induction of muscle necrosis.
Peggion Caterina, Tonello Fiorella
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SLiMScape: a protein short linear motif analysis plugin for Cytoscape. [PDF]
BMC Bioinformatics, 2013 Abstract Background Computational protein short linear motif discovery can use protein interaction information to search for motifs among proteins which share a common interactor. Cytoscape provides a visual interface for protein networks but there is no streamlined way to rapidly visualize motifs in a network of ...
O'Brien KT, Haslam NJ, Shields DC.
europepmc +5 more sources
Systematic discovery of new recognition peptides mediating protein interaction networks. [PDF]
PLoS Biology, 2005 Many aspects of cell signalling, trafficking, and targeting are governed by interactions between globular protein domains and short peptide segments. These domains often bind multiple peptides that share a common sequence pattern, or "linear motif" (e.g.,
Victor Neduva +9 more
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