The calmodulin-binding, short linear motif, NSCaTE is conserved in L-type channel ancestors of vertebrate Cav1.2 and Cav1.3 channels. [PDF]
PLoS ONE, 2013 NSCaTE is a short linear motif of (xWxxx(I or L)xxxx), composed of residues with a high helix-forming propensity within a mostly disordered N-terminus that is conserved in L-type calcium channels from protostome invertebrates to humans.
Valentina Taiakina +6 more
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Elucidation of Short Linear Motif-Based Interactions of the FERM Domains of Ezrin, Radixin, Moesin, and Merlin. [PDF]
Biochemistry, 2023 The ERM (ezrin, radixin, and moesin) family of proteins and the related protein merlin participate in scaffolding and signaling events at the cell cortex.
Ali M +4 more
europepmc +2 more sources
FOXP in Tetrapoda: Intrinsically Disordered Regions, Short Linear Motifs and their evolutionary significance [PDF]
Genetics and Molecular Biology, 2017 The FOXP subfamily is probably the most extensively characterized subfamily of the forkhead superfamily, playing important roles in development and homeostasis in vertebrates.
Lucas Henriques Viscardi +7 more
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Short linear motifs—underexplored players driving Toxoplasma gondii infection [PDF]
Microbiology SpectrumPathogens infect hosts by interacting with host proteins and exploiting their functions to their advantage. Short linear motifs, small functional regions within intrinsically disordered protein regions, are common mediators of host-pathogen protein ...
Jesús Alvarado Valverde +5 more
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Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications [PDF]
Science Signaling, 2021 Manjeet Kumar +2 more
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Redefining the BH3 Death Domain as a 'Short Linear Motif'. [PDF]
Trends Biochem Sci, 2015 B cell lymphoma-2 (BCL-2)-related proteins control programmed cell death through a complex network of protein-protein interactions mediated by BCL-2 homology 3 (BH3) domains. Given their roles as dynamic linchpins, the discovery of novel BH3-containing proteins has attracted considerable attention.
Aouacheria A +3 more
europepmc +5 more sources
Defining short linear motif binding determinants by phage display-based deep mutational scanning [PDF]
Protein ScienceIfigenia Tsitsa +2 more
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ELM-the Eukaryotic Linear Motif resource-2024 update. [PDF]
, 2023 Short Linear Motifs (SLiMs) are the smallest structural and functional components of modular eukaryotic proteins. They are also the most abundant, especially when considering post-translational modifications. As well as being found throughout the cell as
Dean, K +54 more
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SLiMScape: a protein short linear motif analysis plugin for Cytoscape. [PDF]
BMC Bioinformatics, 2013 Abstract Background Computational protein short linear motif discovery can use protein interaction information to search for motifs among proteins which share a common interactor. Cytoscape provides a visual interface for protein networks but there is no streamlined way to rapidly visualize motifs in a network of ...
O'Brien KT, Haslam NJ, Shields DC.
europepmc +5 more sources
Systematic discovery of new recognition peptides mediating protein interaction networks. [PDF]
PLoS Biology, 2005 Many aspects of cell signalling, trafficking, and targeting are governed by interactions between globular protein domains and short peptide segments. These domains often bind multiple peptides that share a common sequence pattern, or "linear motif" (e.g.,
Victor Neduva +9 more
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