Results 31 to 40 of about 6,347,071 (258)

Short Linear Motifs in Colorectal Cancer Interactome and Tumorigenesis

Cells, 2022
Colorectal tumorigenesis is driven by alterations in genes and proteins responsible for cancer initiation, progression, and invasion. This multistage process is based on a dense network of protein–protein interactions (PPIs) that become dysregulated as a result of changes in various cell signaling effectors.
Fasano, Candida, Grossi, Valentina, Forte, Giovanna, Simone, Cristiano   +3 more
openaire   +4 more sources

Resources to Discover and Use Short Linear Motifs in Viral Proteins [PDF]

Trends in Biotechnology, 2020
Viral proteins evade host immune function by molecular mimicry, often achieved by short linear motifs (SLiMs) of three to ten consecutive amino acids (AAs). Motif mimicry tolerates mutations, evolves quickly to modify interactions with the host, and enables modular interactions with protein complexes.
Peter Hraber, Paul E. O’Maille, Andrew Silberfarb, Katie Davis-Anderson, Nicholas Generous, Benjamin H. McMahon, Jeanne M. Fair   +6 more
openaire   +2 more sources

Short Linear Motifs Characterizing Snake Venom and Mammalian Phospholipases A2 [PDF]

Toxins, 2021
Snake venom phospholipases A2 (PLA2s) have sequences and structures very similar to those of mammalian group I and II secretory PLA2s, but they possess many toxic properties, ranging from the inhibition of coagulation to the blockage of nerve transmission, and the induction of muscle necrosis.
Peggion Caterina, Tonello Fiorella
openaire   +3 more sources

A distributed residue network permits conformational binding specificity in a conserved family of actin remodelers

eLife, 2021
Metazoan proteomes contain many paralogous proteins that have evolved distinct functions. The Ena/VASP family of actin regulators consists of three members that share an EVH1 interaction domain with a 100 % conserved binding site.
Theresa Hwang, Sara S Parker, Samantha M Hill, Meucci W Ilunga, Robert A Grant, Ghassan Mouneimne, Amy E Keating   +6 more
doaj   +1 more source

SLiMSearch 2.0: biological context for short linear motifs in proteins [PDF]

Nucleic Acids Research, 2011
Short, linear motifs (SLiMs) play a critical role in many biological processes. The SLiMSearch 2.0 (Short, Linear Motif Search) web server allows researchers to identify occurrences of a user-defined SLiM in a proteome, using conservation and protein disorder context statistics to rank occurrences.
Norman E. Davey, Niall J. Haslam, Denis C. Shields, Richard J. Edwards   +3 more
openaire   +4 more sources

Phylogenomics-guided discovery of a novel conserved cassette of short linear motifs in BubR1 essential for the spindle checkpoint [PDF]

Open Biology, 2016
The spindle assembly checkpoint (SAC) maintains genomic integrity by preventing progression of mitotic cell division until all chromosomes are stably attached to spindle microtubules. The SAC critically relies on the paralogues Bub1 and BubR1/Mad3, which
Eelco Tromer, Debora Bade, Berend Snel, Geert J. P. L. Kops   +3 more
doaj   +1 more source

Integrated analysis of Shank1 PDZ interactions with C-terminal and internal binding motifs

Current Research in Structural Biology, 2021
PDZ domains constitute a large family of modular domains that are well-known for binding C-terminal motifs of target proteins. Some of them also bind to internal PDZ binding motifs (PDZbms), but this aspect of the PDZ interactome is poorly studied.
Muhammad Ali, Mishal Mariam McAuley, Susanne Lüchow, Stefan Knapp, Andreas C. Joerger, Ylva Ivarsson   +5 more
doaj   +1 more source

Ehrlichia SLiM Ligand Mimetic Activates Notch Signaling in Human Monocytes

mBio, 2022
Ehrlichia chaffeensis evades innate host defenses by reprogramming the mononuclear phagocyte through mechanisms that involve the exploitation of multiple evolutionarily conserved cellular signaling pathways, including Notch.
LaNisha L. Patterson, Thangam Sudha Velayutham, Caitlan D. Byerly, Duc Cuong Bui, Jignesh Patel, Veljko Veljkovic, Slobodan Paessler, Jere W. McBride   +7 more
doaj   +1 more source

Native proline-rich motifs exploit sequence context to target actin-remodeling Ena/VASP protein ENAH

eLife, 2022
The human proteome is replete with short linear motifs (SLiMs) of four to six residues that are critical for protein-protein interactions, yet the importance of the sequence surrounding such motifs is underexplored.
Theresa Hwang, Sara S Parker, Samantha M Hill, Robert A Grant, Meucci W Ilunga, Venkatesh Sivaraman, Ghassan Mouneimne, Amy E Keating   +7 more
doaj   +1 more source

A short linear motif in BNIP3L (NIX) mediates mitochondrial clearance in reticulocytes. [PDF]

Autophagy, 2012
Elimination of defective mitochondria is essential for the health of long-lived, postmitotic cells. To gain insight into this process, we examined programmed mitochondrial clearance in reticulocytes. BNIP3L is a mitochondrial outer membrane protein that is required for clearance.
Zhang J, Loyd MR, Randall MS, Waddell MB, Kriwacki RW, Ney PA.   +5 more
europepmc   +4 more sources