Results 31 to 40 of about 237,743 (266)

Short Linear Motifs in Colorectal Cancer Interactome and Tumorigenesis

Cells, 2022
Colorectal tumorigenesis is driven by alterations in genes and proteins responsible for cancer initiation, progression, and invasion. This multistage process is based on a dense network of protein–protein interactions (PPIs) that become dysregulated as a result of changes in various cell signaling effectors.
Fasano, Candida, Grossi, Valentina, Forte, Giovanna, Simone, Cristiano   +3 more
openaire   +4 more sources

Short linear motifs – ex nihilo evolution of protein regulation [PDF]

Cell Communication and Signaling, 2015
Short sequence motifs are ubiquitous across the three major types of biomolecules: hundreds of classes and thousands of instances of DNA regulatory elements, RNA motifs and protein short linear motifs (SLiMs) have been characterised. The increase in complexity of transcriptional, post-transcriptional and post-translational regulation in higher ...
Davey, Norman E, Cyert, Martha S, Moses, Alan M   +2 more
openaire   +3 more sources

Thousands of protein linear motif classes may still be undiscovered.

PLoS ONE, 2021
Linear motifs are short protein subsequences that mediate protein interactions. Hundreds of motif classes including thousands of motif instances are known. Our theory estimates how many motif classes remain undiscovered.
Denys Bulavka, Ariel A Aptekmann, Nicolás A Méndez, Teresa Krick, Ignacio E Sánchez   +4 more
doaj   +1 more source

Computational identification and analysis of protein short linear motifs [PDF]

Frontiers in Bioscience, 2010
Short linear motifs (SLiMs) in proteins can act as targets for proteolytic cleavage, sites of post-translational modification, determinants of sub-cellular localization, and mediators of protein-protein interactions. Computational discovery of SLiMs involves assembling a group of proteins postulated to share a potential motif, masking out residues less
Davey, Norman E., Edwards, Richard J., Shields, Denis C.   +2 more
openaire   +3 more sources

The SLiMDisc server: short, linear motif discovery in proteins [PDF]

Nucleic Acids Research, 2007
Short, linear motifs (SLiMs) play a critical role in many biological processes, particularly in protein-protein interactions. Overrepresentation of convergent occurrences of motifs in proteins with a common attribute (such as similar subcellular location or a shared interaction partner) provides a feasible means to discover novel occurrences ...
Davey, Norman E., Edwards, Richard J., Shields, Denis C.   +2 more
openaire   +4 more sources

Systematic discovery of Short Linear Motifs decodes calcineurin phosphatase signaling [PDF]

Molecular Cell, 2019
SummaryShort linear motifs (SLiMs) drive dynamic protein-protein interactions essential for signaling, but sequence degeneracy and low binding affinities make them difficult to identify. We harnessed unbiased systematic approaches for SLiM discovery to elucidate the regulatory network of calcineurin (CN)/PP2B, the Ca2+-activated phosphatase that ...
Wigington, CP, Roy, J, Damle, NP, Yadav, VK, Blikstad, C, Resch, E, Wong, CJ, Mackay, DR, Wang, JT, Krystkowiak, I, Bradburn, DA, Tsekitsidou, E, Hong, SH, Kaderali, MA, Xu, S-L, Stearns, T, Gingras, A-C, Ullman, KS, Ivarsson, Y, Davey, NE, Cyert, MS   +20 more
openaire   +3 more sources

A distributed residue network permits conformational binding specificity in a conserved family of actin remodelers

eLife, 2021
Metazoan proteomes contain many paralogous proteins that have evolved distinct functions. The Ena/VASP family of actin regulators consists of three members that share an EVH1 interaction domain with a 100 % conserved binding site.
Theresa Hwang, Sara S Parker, Samantha M Hill, Meucci W Ilunga, Robert A Grant, Ghassan Mouneimne, Amy E Keating   +6 more
doaj   +1 more source

Phylogenomics-guided discovery of a novel conserved cassette of short linear motifs in BubR1 essential for the spindle checkpoint [PDF]

Open Biology, 2016
The spindle assembly checkpoint (SAC) maintains genomic integrity by preventing progression of mitotic cell division until all chromosomes are stably attached to spindle microtubules. The SAC critically relies on the paralogues Bub1 and BubR1/Mad3, which
Eelco Tromer, Debora Bade, Berend Snel, Geert J. P. L. Kops   +3 more
doaj   +1 more source

Evidence for the concerted evolution between short linear protein motifs and their flanking regions. [PDF]

PLoS ONE, 2009
BACKGROUND: Linear motifs are short modules of protein sequences that play a crucial role in mediating and regulating many protein-protein interactions. The function of linear motifs strongly depends on the context, e.g. functional instances mainly occur
Claudia Chica, Francesca Diella, Toby J Gibson   +2 more
doaj   +1 more source

Integrated analysis of Shank1 PDZ interactions with C-terminal and internal binding motifs

Current Research in Structural Biology, 2021
PDZ domains constitute a large family of modular domains that are well-known for binding C-terminal motifs of target proteins. Some of them also bind to internal PDZ binding motifs (PDZbms), but this aspect of the PDZ interactome is poorly studied.
Muhammad Ali, Mishal Mariam McAuley, Susanne Lüchow, Stefan Knapp, Andreas C. Joerger, Ylva Ivarsson   +5 more
doaj   +1 more source