Results 51 to 60 of about 237,743 (266)

GibbsCluster: unsupervised clustering and alignment of peptide sequences [PDF]

, 2017
Receptor interactions with short linear peptide fragments (ligands) are at the base of many biological signaling processes. Conserved and information-rich amino acid patterns, commonly called sequence motifs, shape and regulate these interactions ...
Alvarez, Bruno, Andreatta, Massimo, Nielsen, Morten   +2 more
core   +2 more sources

Structural Mechanism for the Specific Assembly and Activation of the Extracellular Signal Regulated Kinase 5 (ERK5) Module [PDF]

, 2013
Mitogen-activated protein kinase (MAPK) activation depends on a linear binding motif found in all MAPK kinases (MKK). In addition, the PB1 (Phox and Bem1) domain of MKK5 is required for extracellular signal regulated kinase 5 (ERK5) activation.
Aberg, Adams, Alexander, Bardwell, Barsyte-Lovejoy, Bhattacharyya, Bhattacharyya, Buschbeck, Caffrey, Cavanaugh, Chang, Chen, Coulombe, Drew, Emsley, Garai, Guo, Gupta, Gógl, Hayashi, Hu, Jacobs, Kabsch, Kato, Kato, Kondoh, Li, Liu, Liu, Liu, Ma, McCoy, Milanesi, Moscat, Murakami, Nakamura, Nakamura, Nakamura, Nishimoto, Pearson, Piserchio, Potthoff, Raman, Ranganathan, Regan, Reményi, Sharrocks, Sohn, Tanoue, Wang, Watson, Winn, Won, Zarrinpar, Zeke, Zhang, Zhou, Zhou   +57 more
core   +1 more source

Correction: The Calmodulin-Binding, Short Linear Motif, NSCaTE Is Conserved in L-Type Channel Ancestors of Vertebrate Cav1.2 and Cav1.3 Channels

PLoS ONE, 2014
Valentina Taiakina, Adrienne N. Boone, Julia Fux, Adriano Senatore, Danielle Weber-Adrian, J. Guy Guillemette, J. David Spafford   +6 more
doaj   +4 more sources

Short linear motifs in intrinsically disordered regions modulate HOG signaling capacity [PDF]

BMC Systems Biology, 2017
AbstractThe effort to characterize intrinsically disordered regions of signaling proteins is rapidly expanding. An important class of disordered interaction modules are ubiquitous and functionally diverse elements known as short linear motifs (SLiMs).
Strome, Bob, Hsu, Ian S, Li Cheong Man, Mitchell, Zarin, Taraneh, Nguyen Ba, Alex, Moses, Alan M   +5 more
openaire   +3 more sources

How different viruses perturb host cellular machinery via short linear motifs

EXCLI journal, 2023
EXCLI Journal; 22:Doc1113; ISSN 1611 ...
Sobia Idrees, Keshav Raj Paudel, Tayyaba Sadaf, Philip M. Hansbro   +3 more
openaire   +3 more sources

Measuring microsatellite conservation in mammalian evolution with a phylogenetic birth-death model. [PDF]

, 2012
Microsatellites make up ∼3% of the human genome, and there is increasing evidence that some microsatellites can have important functions and can be conserved by selection.
Buschiazzo, Emmanuel, Gemmell, Neil, Lennon, Dustin, Minin, Vladimir N, Sawaya, Sterling M   +4 more
core   +1 more source

Proline-Rich Motifs Control G2-CDK Target Phosphorylation and Priming an Anchoring Protein for Polo Kinase Localization

Cell Reports, 2020
Summary: The hydrophobic patch (hp), a docking pocket on cyclins of CDKs (cyclin-dependent kinases), has been thought to accommodate a single short linear motif (SLiM), the “RxL or Cy” docking motif.
Mihkel Örd, Kait Kaarel Puss, Rait Kivi, Kaidi Möll, Tuuliki Ojala, Irina Borovko, Ilona Faustova, Rainis Venta, Ervin Valk, Mardo Kõivomägi, Mart Loog   +10 more
doaj   +1 more source

Novel linear motif filtering protocol reveals the role of the LC8 dynein light chain in the Hippo pathway. [PDF]

PLoS Computational Biology, 2017
Protein-protein interactions (PPIs) formed between short linear motifs and globular domains play important roles in many regulatory and signaling processes but are highly underrepresented in current protein-protein interaction databases.
Gábor Erdős, Tamás Szaniszló, Mátyás Pajkos, Borbála Hajdu-Soltész, Bence Kiss, Gábor Pál, László Nyitray, Zsuzsanna Dosztányi   +7 more
doaj   +1 more source

Two Mycenaean Stirrup-jars from the Levant [PDF]

, 2015
A cache of artifacts, recovered in 2014 by the cultural heritage squadron of the Guardia di Finanza (Gruppo Tutela Patrimonio Archeologico of the Nucleo Polizia Tributaria di Roma), included two Mycenaean stirrup jars among the pottery illegally brought ...
SPAGNOLI, FEDERICA
core   +1 more source

Computational Prediction of Short Linear Motifs from Protein Sequences

, 2014
Short Linear Motifs (SLiMs) are functional protein microdomains that typically mediate interactions between a short linear region in one protein and a globular domain in another. SLiMs usually occur in structurally disordered regions and mediate low affinity interactions.
Edwards, Richard J., Palopoli, Nicolas
openaire   +4 more sources