Results 51 to 60 of about 6,347,071 (258)

Diversity of Short Linear Interaction Motifs in SARS-CoV-2 Nucleocapsid Protein

mBio, 2023
SUMMARY Molecular mimicry of short linear interaction motifs has emerged as a key mechanism for viral proteins binding host domains and hijacking host cell processes. Here, we examine the role of RNA-virus sequence diversity in the dynamics of the virus-host interface, by analyzing the uniquely vast sequence record of
Peter Schuck, Huaying Zhao
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Novel linear motif filtering protocol reveals the role of the LC8 dynein light chain in the Hippo pathway. [PDF]

PLoS Computational Biology, 2017
Protein-protein interactions (PPIs) formed between short linear motifs and globular domains play important roles in many regulatory and signaling processes but are highly underrepresented in current protein-protein interaction databases.
Gábor Erdős, Tamás Szaniszló, Mátyás Pajkos, Borbála Hajdu-Soltész, Bence Kiss, Gábor Pál, László Nyitray, Zsuzsanna Dosztányi   +7 more
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Computational Investigation of Structural Interfaces of Protein Complexes with Short Linear Motifs [PDF]

Journal of Proteome Research, 2020
Abstract Protein complexes with short linear motifs (SLiMs) are known to play important regulatory functions in eukaryotes. In this investigation, I have studied the structures deposited in PDB with SLiMs. The structures Were grouped into three broad categories of protein-protein, protein-peptide and the rest as others.
openaire   +2 more sources

Detecting Multiple Motif Co-occurrences in the Aarne-Thompson-Uther Tale Type Catalog: A Preliminary Survey [PDF]

, 2011
Catalogs project subject field experience onto a multidimensional map which is then converted to a hierarchical list. In the case of the Aarne-Thompson-Uther Tale Type Catalog (ATU), this subject field is the global pattern of tale content defining tale ...
Darányi, Sándor, Forró, László, Sándor Darányi, László Forró, Darányi, Sándor,   +4 more
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Structure and Dynamics in the ATG8 Family From Experimental to Computational Techniques

Frontiers in Cell and Developmental Biology, 2020
Autophagy is a conserved and essential intracellular mechanism for the removal of damaged components. Since autophagy deregulation is linked to different kinds of pathologies, it is fundamental to gain knowledge on the fine molecular and structural ...
Valentina Sora, Mukesh Kumar, Emiliano Maiani, Matteo Lambrughi, Matteo Tiberti, Elena Papaleo, Elena Papaleo   +6 more
doaj   +1 more source

A dynamic view of domain-motif interactions. [PDF]

PLoS Computational Biology, 2012
Many protein-protein interactions are mediated by domain-motif interaction, where a domain in one protein binds a short linear motif in its interacting partner.
Eyal Akiva, Gilgi Friedlander, Zohar Itzhaki, Hanah Margalit   +3 more
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Cell signaling in Ehrlichia infection and cancer: Parallels in pathogenesis

Frontiers in Cellular and Infection Microbiology
Ehrlichia chaffeensis (E. chaffeensis) has recently emerged as an intracellular bacterial pathogen with sophisticated survival mechanisms that include repurposing evolutionarily conserved eukaryotic cell signaling pathways for immune evasion.
Regina N. Solomon, Nicholas A. Pittner, Jaclyn R. McCoy, Paityn A. Warwick, Jere W. McBride, Jere W. McBride, Jere W. McBride, Jere W. McBride, Jere W. McBride   +8 more
doaj   +1 more source

Computational Prediction of Short Linear Motifs from Protein Sequences

, 2014
Short Linear Motifs (SLiMs) are functional protein microdomains that typically mediate interactions between a short linear region in one protein and a globular domain in another. SLiMs usually occur in structurally disordered regions and mediate low affinity interactions.
Edwards, Richard J., Palopoli, Nicolas
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Short linear motifs in intrinsically disordered regions modulate HOG signaling capacity [PDF]

BMC Systems Biology, 2017
Abstract The effort to characterize intrinsically disordered regions of signaling proteins is rapidly expanding. An important class of disordered interaction modules are ubiquitous and functionally diverse elements known as short linear motifs (SLiMs).
Bob Strome, Ian Shenyen Hsu, Mitchell Li Cheong Man, Taraneh Zarin, Alex N. Nguyen Ba, Alan M. Moses   +5 more
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Discovery of short linear motif-mediated interactions through phage display of intrinsically disordered regions of the human proteome.

, 2016
The intrinsically disordered regions of eukaryotic proteomes are enriched in short linear motifs (SLiMs), which are of crucial relevance for cellular signaling and protein regulation; many mediate interactions by providing binding sites for peptide ...
Yadav, V.
core   +1 more source