Results 41 to 50 of about 6,347,071 (258)
Short linear motifs – ex nihilo evolution of protein regulation [PDF]
Cell Communication and Signaling, 2015 Short sequence motifs are ubiquitous across the three major types of biomolecules: hundreds of classes and thousands of instances of DNA regulatory elements, RNA motifs and protein short linear motifs (SLiMs) have been characterised. The increase in complexity of transcriptional, post-transcriptional and post-translational regulation in higher ...
Davey, Norman E +2 more
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Ehrlichia effector SLiM-icry: Artifice of cellular subversion
Frontiers in Cellular and Infection Microbiology, 2023 As an obligately intracellular bacterial pathogen that selectively infects the mononuclear phagocyte, Ehrlichia chaffeensis has evolved sophisticated mechanisms to subvert innate immune defenses. While the bacterium accomplishes this through a variety of
Nicholas A. Pittner +7 more
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The identification of short linear motif-mediated interfaces within the human interactome. [PDF]
Bioinformatics, 2012 Abstract Motivation: Eukaryotic proteins are highly modular, containing multiple interaction interfaces that mediate binding to a network of regulators and effectors. Recent advances in high-throughput proteomics have rapidly expanded the number of known protein–protein interactions (PPIs); however, the molecular basis for the majority ...
Weatheritt RJ +4 more
europepmc +4 more sources
МЕБИЈУСОВА ТРАКА: ВРЕМЕНСКА ПЕТЉА У РОМАНУ ДЕЈАНА АЛЕКСИЋА ЦИПЕЛА НА КРАЈУ СВЕТА [PDF]
International Journal of Slavic Studies, 2020 This article investigates the time loop motif in Dejan Aleksić’s novel, A Shoe at the End of the World. Following a brief overview of the most important uses of the time motif in children’s literature, and positioning this paper within Nikolajeva’s (i ...
Тијана Тропин
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Orchestrating serine/threonine phosphorylation and elucidating downstream effects by short linear motifs [PDF]
Biochemical Journal, 2022 Cellular function is based on protein–protein interactions. A large proportion of these interactions involves the binding of short linear motifs (SLiMs) by folded globular domains. These interactions are regulated by post-translational modifications, such as phosphorylation, that create and break motif binding sites or tune the affinity of the ...
Johanna Kliche, Ylva Ivarsson
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PLoS Pathogens, 2013 A central challenge in host-pathogen systems biology is the elucidation of general, systems-level principles that distinguish host-pathogen interactions from within-host interactions.
Sara Garamszegi, Eric A Franzosa, Yu Xia
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Cell Reports, 2020 Summary: The hydrophobic patch (hp), a docking pocket on cyclins of CDKs (cyclin-dependent kinases), has been thought to accommodate a single short linear motif (SLiM), the “RxL or Cy” docking motif.
Mihkel Örd +10 more
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Correlating motif analysis and morphological filters for surface texture analysis [PDF]
, 2013 In contrast to the mean-line based evaluation system, motif analysis and morphological filters are two techniques oriented to the characterization of functional properties of surfaces.
Lou, Shan +2 more
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Understanding protein multifunctionality: from short linear motifs to cellular functions [PDF]
Cellular and Molecular Life Sciences, 2019 Moonlighting proteins perform multiple unrelated functions without any change in polypeptide sequence. They can coordinate cellular activities, serving as switches between pathways and helping to respond to changes in the cellular environment. Therefore, regulation of the multiple protein activities, in space and time, is likely to be important for the
Zanzoni, Andreas +2 more
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