Results 61 to 70 of about 518,855 (348)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Earthquake Source and Seismic Strain Rate: Portugal in the Context of The Western Part of the Eurasia - Africa Plate Boundary [PDF]

open access: yes, 2004
Fault plane solutions, stress-pattern and deformation rate along the Western part of the Eurasia-Africa Plate Boundary, particu- larly between Azores triple junction and Gibraltar are analyzed.
Bezzeghoud, M   +3 more
core  

Quantifying the slip rates, spatial distribution and evolution of active normal faults from geomorphic analysis: Field examples from an oblique-extensional graben, southern Turkey [PDF]

open access: yes, 2009
Quantifying the extent to which geomorphic features can be used to extract tectonic signals is a key challenge in the Earth Sciences. Here we analyse the drainage patterns, geomorphic impact, and long profiles of bedrock rivers that drain across and ...
Boulton, SJ, Whittaker, AC
core   +2 more sources

Experimental Evaluation of 100Cr6 Steel Microindented Surfaces Under Lubricated Nonconformal Point Contacts

open access: yesAdvanced Engineering Materials, EarlyView.
The tribological behavior of 100Cr6 steel spheres textured via Vickers microindentation is evaluated under lubricated sliding by varying both dimple size and density. Fine and dense textures significantly reduce friction across all lubrication regimes, while large dimples increase it.
Farideh Davoodi   +3 more
wiley   +1 more source

Experimental Investigation of the Effect of Fault Reactivation Induced by Water Injection

open access: yesApplied Sciences
An understanding of fault reactivation induced by water injection is of great significance for geothermal energy development and utilization. We conducted a series of water injection shear tests on low-permeability granite samples that each contained a ...
Wenjing Liu, Hu Si
doaj   +1 more source

A Universal Molecular-Kinetic Scaling Relation for Slip of a Simple Fluid at a Solid Boundary

open access: yes, 2019
Using the observation that slip in simple fluids at low and moderate shear rates is a thermally activated process driven by the shear stress in the fluid close to the solid boundary, we develop a molecular-kinetic model for simple fluid slip at solid ...
Hadjiconstantinou, Nicolas G.   +1 more
core   +1 more source

On the Lightweight Potential of Laser Additive Manufactured NiTi Triply Periodic Minimal Sheet Lattices

open access: yesAdvanced Engineering Materials, EarlyView.
This study explores the lightweight potential of laser additive‐manufactured NiTi triply periodic minimal surface sheet lattices. It systematically investigates the effects of relative density and unit cell size on surface quality, deformation recovery, compression behavior, and energy absorption.
Haoming Mo   +3 more
wiley   +1 more source

Current Slip and Strain Rate Distribution Along the Ganzi-Yushu-Xianshuihe Fault System Based on InSAR and GPS Observations

open access: yesFrontiers in Earth Science, 2022
The Ganzi-Yushu-Xianshuihe fault (GYXSF), a large strike-slip fault located on the east side of the Tibetan Plateau, has seen high seismic activity in recent years.
Wenting Zhang   +12 more
doaj   +1 more source

A Workflow to Accelerate Microstructure‐Sensitive Fatigue Life Predictions

open access: yesAdvanced Engineering Materials, EarlyView.
This study introduces a workflow to accelerate predictions of microstructure‐sensitive fatigue life. Results from frameworks with varying levels of simplification are benchmarked against published reference results. The analysis reveals a trade‐off between accuracy and model complexity, offering researchers a practical guide for selecting the optimal ...
Luca Loiodice   +2 more
wiley   +1 more source

Probabilistic Assessment of Slip Rates and Their Variability Over Time of Offshore Buried Thrusts: A Case Study in the Northern Adriatic Sea

open access: yesFrontiers in Earth Science, 2021
When sedimentation rates overtake tectonic rates, the detection of ongoing tectonic deformation signatures becomes particularly challenging. The Northern Apennines orogen is one such case where a thick Plio-Pleistocene foredeep sedimentary cover blankets
Yuri Panara   +8 more
doaj   +1 more source

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