Results 191 to 200 of about 58,468 (266)

Phosphatidylinositol-3-kinase/Protein Kinase B (PI3K/AKT) and Nucleotide-Binding Oligomerization Domain-like Receptor Family Pyrin Domain Containing 3 (NLRP3) Inflammasome Modulation Underlies the Neuroprotective Effects of Vildagliptin in a Rotenone-Induced Mouse Model of Parkinson's Disease. [PDF]

ACS Pharmacol Transl Sci
Patel D, Soni R, Bhogal I, Roy S, Shah J.   +4 more
europepmc   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

Stacking in Layered Covalent Organic Frameworks: A Computational Approach and PXRD Reference Guide. [PDF]

Int J Mol Sci
Steentjes R, Zojer E.
europepmc   +1 more source

Architected Inverse Nacre Hydrogels With High Strength and Crack‐Insensitive Toughness

Advanced Science, EarlyView.
Hydrogels hold promise for biomedical and engineering applications, yet their practical use is fundamentally limited by the strength‐toughness trade‐off and poor fatigue resistance. In this study, a bioinspired inverse nacre architecture constructed via a scalable thermo‐calendering process is introduced, which overcomes these classic limitations ...
Haidi Wu, Qin Su, Cheng Guan, Biwang Pan, Wenjie Hu, Jun Yan, Yifan Feng, Longcheng Tang, Xuewu Huang, Jiefeng Gao, Wancheng Gu   +10 more
wiley   +1 more source

A Review of Pediatric Orthopedic Disorders: Diagnosis and Treatment Updates. [PDF]

Cureus
P S, Diwakar R, Singh S, Gujarathi RH, Purohit BJ, Patni K.   +5 more
europepmc   +1 more source

When Muscle Lines Blur: An Unusual Fusion of Trapezius and Sternocleidomastoid With Surgical Relevance. [PDF]

Cureus
Sharma V, Panchal P, Babu CSR.
europepmc   +1 more source

Assessing the biomechanical characteristics of defensive movements in elite boxers of different competitive levels. [PDF]

BMC Sports Sci Med Rehabil
Wang X, Korobeynikov G.
europepmc   +1 more source

Clinical and radiological outcomes of bimalleolar ankle fractures treated with open reduction and internal fixation: a prospective observational study. [PDF]

J Trauma Inj
Vsv K, Srinivasan V, S R, Adaikkappan M, A S H.   +4 more
europepmc   +1 more source