Results 111 to 120 of about 133,728 (356)

SIRT1 Prevents Ferroptosis in Corneal Epithelial Cells by Enhancing HIF1α Protein Stability in Dry Eye Disease

open access: yesAdvanced Science, EarlyView.
Hyperosmotic stress drives ferroptosis in corneal epithelium via SIRT1 downregulation. This work demonstrates that SIRT1 activation stabilizes HIF1α, which transcriptionally upregulates GPX4 to inhibit lipid peroxidation and cell death. The identified SIRT1/HIF1α/GPX4 axis reveals a novel defense mechanism and potential therapy for dry eye disease ...
Lili Lian   +11 more
wiley   +1 more source

Space station science lab module [PDF]

open access: yes
The Science Lab Module (SLM), a key component of the proposed Space Station (SS) orbiting complex, is undergoing intensive study during the project design phase which is currently underway.
Devincenzi, D. L.
core   +1 more source

Cox rings of moduli of quasi parabolic principal bundles and the K-Pieri rule

open access: yes, 2016
We study a toric degeneration of the Cox ring of the moduli of principal $SL_m(\mathbb{C})$ bundles on the projective line, with quasi parabolic data given by the the stabilizer of the highest weight vector in $\mathbb{C}^m$ and its dual $\bigwedge^{m-1}(
Manon, Christopher
core   +1 more source

Data‐Driven Design and Fabrication of Heat‐Resistant, Ultrastrong, Lightweight Aluminum‐Based Entropy Alloy by Additive Manufacturing

open access: yesAdvanced Science, EarlyView.
A data‐driven strategy integrating quantum machine learning (QML) and high‐throughput computing overcomes hot‐cracking limitation to design a novel lightweight aluminum‐based entropy alloy for additive manufacturing. The fabrication transforms brittle intermetallics into deformable hierarchical nanostructures, yielding ultrastrong strength (>1 GPa) and
Enmao Wang   +6 more
wiley   +1 more source

Temporal recompression through a scattering medium via a broadband transmission matrix

open access: yes, 2017
The transmission matrix is a unique tool to control light through a scattering medium. A monochromatic transmission matrix does not allow temporal control of broadband light.
de Aguiar, Hilton B.   +2 more
core   +1 more source

Deciphering the Impact of RAC1‐SPTAN1 in ARPKD Cystogenesis Using Multifaceted Models

open access: yesAdvanced Science, EarlyView.
Distal/connecting tubules expressing SLC8A1 have been suggested as a potential origin of ARPKD cysts. SPTAN1 has been identified as a key molecule in ARPKD cyst formation. Restoring SPTAN1 in PKHD1−/− organoids reduced cyst formation, normalized calcium levels, and decreased RAC1/c‐FOS expression, highlighting SPTAN1's role in ARPKD and the potential ...
Shohei Kuraoka   +9 more
wiley   +1 more source

Ownership structure and capital structure dynamics in South African firms

open access: yesSouth African Journal of Economic and Management Sciences
Background: The ownership structure can impact capital structure decisions as owners are an influential group that govern the financial decisions of firms.
Delane Naidu
doaj   +1 more source

On-site and off-Site long-term economic impacts of soil fertility management practices: The case of maize-based cropping systems in Kenya [PDF]

open access: yes
"This article analyzes the on-site and off-site economic impacts of various sustainable land management (SLM) practices in Kenya. Long-term trial data are used to establish the relationship between SLM practices and maize yield.
Gachimbi, Louis N.   +5 more
core  

Home - About - Disclaimer - Privacy