Results 121 to 130 of about 768,167 (327)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Determination of the Safe Orientation and Dip of a Rock Slope in an Open Pit Mine in Syria Using Kinematic Analysis

open access: yesمجلة النهرين للعلوم الهندسية, 2017
This paper presents a method for choosing the orientation and the dip of an excavated rock slope, to safely serve the intended function of the slope or the excavation.
Kinan ZainAlabideen, Maan Helal
doaj  

CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez   +12 more
wiley   +1 more source

Deep Learning–Assisted Differentiation of Four Peripheral Neuropathies Using Corneal Confocal Microscopy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peripheral neuropathies contribute to patient disability but may be diagnosed late or missed altogether due to late referral, limitation of current diagnostic methods and lack of specialized testing facilities. To address this clinical gap, we developed NeuropathAI, an interpretable deep learning–based multiclass classification ...
Chaima Ben Rabah   +7 more
wiley   +1 more source

Analisa Geoteknik Dan Penanggulangan Kelongsoran Tanggul Sungai Banjir Kanal Barat Semarang [PDF]

open access: yes, 2013
This undergraduate thesis is about the landslide Geotechnical Analysis and Landslide Handling on theSlope of West Flood Canal – Semarang. Labile land condition result the slope happened slide, one of the slope is gristle slide there are at WF 80 and WF ...
Hardiyati, S. (Siti)   +3 more
core  

Post‐COVID Fatigue Is Associated With Reduced Cortical Thickness After Hospitalization

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuropsychiatric symptoms are among the most prevalent sequelae of COVID‐19, particularly among hospitalized patients. Recent research has identified volumetric brain changes associated with COVID‐19. However, it currently remains poorly understood how brain changes relate to post‐COVID fatigue and cognitive deficits.
Tim J. Hartung   +190 more
wiley   +1 more source

Evaluasi Stabilitas Lereng Yang Telah Diperkuat Pada Jalan Tol Semarang – Solo Seksi V Ungaran Bawen [PDF]

open access: yes, 2013
Semarang – Solo toll roads, Ungaran Bawen Section was built to support economic growth in Semarang – Solo and its surroundings. The road across the hills and valleys that contain clay shale.
Atmanto, I. D. (Indrastono)   +2 more
core  

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