Results 111 to 120 of about 187,260 (305)

3D finite element back analysis of a large rockslope failure on the East wall of the LAB Chrysotile Mine in Canada

, 2018
A major mining slope failure occurred in July 2012 on the East wall of the LAB Chrysotile mine in Canada. The failure zone was 1000 m x 100 m, with a mobilized volume of 25 hm3.
Grenon, Martin, Caudal, Philippe
core  

FALL CONE TEST CALIBRATION FOR SLOPE STABILITY ANALYSIS

Rudarsko-geološko-naftni Zbornik
Undrained shear strength is considered as an essential factor to assess the stability of natural slopes and embankments. Traditionally, this parameter is determined through laboratory tests, which are often costly and time-consuming.
Chalabi Youssouf, Aissaoui Soufyane, Zadjaoui Abdeldjalil, Aissa Mamoune Sidi Mohammed   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Determination of the Safe Orientation and Dip of a Rock Slope in an Open Pit Mine in Syria Using Kinematic Analysis

مجلة النهرين للعلوم الهندسية, 2017
This paper presents a method for choosing the orientation and the dip of an excavated rock slope, to safely serve the intended function of the slope or the excavation.
Kinan ZainAlabideen, Maan Helal
doaj  

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Slope Stability Analysis Using Unified Strength Theory

, 2011
Numerical computations using finite difference method and unified strength theory are reported to analyze the slope stability problem. The Factor of safety of plane strain and axisymmetric slopes was calculated by strength reducing method, and the ...
Mao Hong Yu, Zong Yuan Ma, Hong Jian Liao   +2 more
core   +1 more source

Stability analysis of road cut slopes in Sikkim Himalaya along national highway 10, India

Geology, Ecology, and Landscapes
The point-specific analysis of slope stability of road cut at nine locations was conducted along NH-10, between Rangpo and Ranipool in Sikkim, India.
Kuldeep Dutta, Nishchal Wanjari, Anil Kumar Misra   +2 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

The stability analysis for high slope excavation of rockmass

, 1997
A complete finite element stress analysis regarding the response for highslope excavation of rock mass is presented. Rock mass is modelled as a linear elastic-perfectly plastic meterial with Drucker - Prager yield condition and its associated flow rule ...
Zhang GD, Zhang, GD (reprint author), Chinese Acad Sci, Inst Mech, Beijing 100080, Peoples R China.   +1 more
core  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source