Results 91 to 100 of about 23,822,382 (306)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Search For Critical Slip Surface In Slope Stability Analysis By Spline-Based Ga Method [PDF]
, 2008 The stability of a soil slope is usually analyzed by limit equilibrium methods, in which the identification of the critical slip surface is of principal importance.
孙建平 +3 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Frontiers in Earth ScienceStrength anisotropy and heterogeneous rotated anisotropy are prevalent phenomena in natural slopes. Previous studies have underscored their significance in slope stability analysis.
Wei Cao +4 more
doaj +1 more source
Three-dimensional strength reduction and two-dimensional limit equilibrium methods of slope stability analysis. [PDF]
Heliyon, 2023 Shirago K, Dirate D.
europepmc +1 more source
Slope stability analysis of critical slope along North South Highway (Southern Region) using limit equilibrium method [PDF]
, 2010 The occurrence of slope failure is always hard to be predicted. Hence, slope stability analysis must be often carried out in order to ensure the slope is safe and also minimise the probability of slope failure.
Jahidin, Mohammed Ridzuan
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Slope stability analysis considering the strength anisotropy of c-φ soil. [PDF]
Sci Rep, 2022 He Y +5 more
europepmc +1 more source
Seismic Stability Analysis of a Himalayan Rock Slope
, 2010 The seismic slope stability analysis of the right abutment of a railway bridge proposed at about 350 m above the ground level, crossing a river and connecting two huge hillocks in the Himalayas, India, is presented in this paper.
Garaga, Arunakumari, Latha, Gali Madhavi
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