Results 101 to 110 of about 23,822,382 (306)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A novel empirical classification method for weak rock slope stability analysis. [PDF]

Sci Rep, 2022
Azarafza M, Hajialilue Bonab M, Derakhshani R.   +2 more
europepmc   +1 more source

Application of Powell's conjugate direction method to slope stability analysis

, 1988
Slope stability problems often arise in construction engineering projects. They are major problems in dams construction and mines excavation. For the purpose of improving the efficiency of slope stability analysis, the optimization method suggested by ...
Abifadel, Nassim Riyad, 1964-
core  

Application of Finite Element Method for safety factor analysis of slope stability

, 2017
[[abstract]]Applications of Finite Element Method in the slope stability analysis are discussed in this study. Influences from different properties of soil material followed by Mohr-Coulomb failure criterion, different angles of slope, different ...
Lu, Chih-Wei;Lai, Shing-Cheng
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Correlations between factor of safety with distributed load and crest length – Zariwam landslide as case study

Geology, Ecology, and Landscapes
This paper examines the impact on Factor of Safety (FS) value due to the variation in distributed load (LD), Crest length (CL), shear strength (τ), and shear stress (σ) both in seismic and non-seismic conditions.
Muhammad Israr Khan
doaj   +1 more source

Instability of blanket bog slopes on Cuilcagh Mountain, N.W. Ireland [PDF]

There are many accounts of slope failures on blanket bogs, but their nature and controls are poorly understood. This study investigates the mechanisms of blanket bog failure on Cuilcagh Mountain, north-west Ireland, and identifies the critical factors ...
Kirk, Kathleen Jane
core  

An integrated approach for rockfall analysis with drapery systems

, 2013
The rockfall hazard in mining environments needs to be rigorously managed in order to ensure safe mining operations, in particular when designing portal entries for punch longwalls. The installation of drapery systems is a common practice to mitigate the
Scott Sloan, Klaus Thoeni, Thoeni, Klaus, Giacomini, Anna, John Carter, Cédric Lambert, Anna Giacomini, Lambert, Cedric, Carter, John P. (R18260), Sloan, Scott W.   +9 more
core   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source