Results 31 to 40 of about 117,118 (314)

Skeletal muscle and fiber type-specific intramyocellular lipid accumulation in obese mice

Biomolecules & Biomedicine, 2021
In obesity, accumulation of lipid droplets in skeletal muscle fibers and a shift towards fast muscle fiber types can both contribute to insulin resistance.
Nejc Umek, Simon Horvat, Erika Cvetko
doaj   +1 more source

Slow motor neuron stimulation of locust skeletal muscle: model and measurement [PDF]

, 2013
The isometric force response of the locust hind leg extensor tibia muscle to stimulation of a slow extensor tibia motor neuron is experimentally investigated, and a mathematical model describing the response presented.
Mace, Brian R., Rustighi, Emiliano, Wilson, Emma, Mace, Brian R, Newland, Philip L, Newland, Philip L., Wilson, Emma Denise   +6 more
core   +1 more source

Minocycline Treatment Reduces Mass and Force Output From Fast-Twitch Mouse Muscles and Inhibits Myosin Production in C2C12 Myotubes

Frontiers in Physiology, 2021
Minocycline, a tetracycline-class of antibiotic, has been tested with mixed effectiveness on neuromuscular disorders such as amyotrophic lateral sclerosis, autoimmune neuritis and muscular dystrophy.
Leonit Kiriaev, Ben D. Perry, David A. Mahns, Peter J. Shortland, Asma Redwan, John W. Morley, Stewart I. Head   +6 more
doaj   +1 more source

The transcriptional coactivator PGC-1α is dispensable for chronic overload-induced skeletal muscle hypertrophy and metabolic remodeling [PDF]

, 2013
Skeletal muscle mass loss and dysfunction have been linked to many diseases. Conversely, resistance exercise, mainly by activating mammalian target of rapamycin complex 1 (mTORC1), promotes skeletal muscle hypertrophy and exerts several therapeutic ...
Handschin, Christoph, Santos, Gesa, Zorzato, Francesco, Perez-Schindler, J, Zorzato, F, Summermatter, S, Summermatter, Serge, Santos, G, Pérez-Schindler, Joaquín, Handschin, C   +9 more
core   +1 more source

Paxilline Prevents the Onset of Myotonic Stiffness in Pharmacologically Induced Myotonia: A Preclinical Investigation

Frontiers in Physiology, 2020
Reduced Cl− conductance causes inhibited muscle relaxation after forceful voluntary contraction due to muscle membrane hyperexcitability. This represents the pathomechanism of myotonia congenita.
Kerstin Hoppe, Kerstin Hoppe, Tina Sartorius, Sunisa Chaiklieng, Sunisa Chaiklieng, Georg Wietzorrek, Peter Ruth, Karin Jurkat-Rott, Scott Wearing, Scott Wearing, Frank Lehmann-Horn, Werner Klingler, Werner Klingler, Werner Klingler, Werner Klingler   +14 more
doaj   +1 more source

Physical inactivity induces insulin resistance in plantaris muscle through protein tyrosine phosphatase 1B activation in mice

Frontiers in Physiology, 2023
Inactivity causes insulin resistance in skeletal muscle and exacerbates various lifestyle-related diseases. We previously found that 24-h hindlimb cast immobilization (HCI) of the predominantly slow-twitch soleus muscle increased intramyocellular ...
Saori Kakehi, Saori Kakehi, Yoshifumi Tamura, Yoshifumi Tamura, Shin-ichi Ikeda, Shin-ichi Ikeda, Naoko Kaga, Hikari Taka, Yuya Nishida, Ryuzo Kawamori, Ryuzo Kawamori, Hirotaka Watada, Hirotaka Watada   +12 more
doaj   +1 more source

Size and Proportions of Slow-Twitch and Fast-Twitch Muscle Fibers in Human Costal Diaphragm

BioMed Research International, 2016
Smaller diaphragmatic motor unit potentials (MUPs) compared to MUPs of limb muscles lead to the hypothesis that diaphragmatic muscle fibers, being the generators of MUPs, might be also smaller.
M. Meznaric, E. Cvetko
semanticscholar   +1 more source

The embryonic genes Dkk3, Hoxd8, Hoxd9 and Tbx1 identify muscle types in a diet-independent and fiber-type unrelated way [PDF]

, 2010
Background The mouse skeletal muscle is composed of four distinct fiber types that differ in contractile function, number of mitochondria and metabolism. Every muscle type has a specific composition and distribution of the four fiber types. To find novel
Boekschoten, M.V., Mariman, E.C.M., Egbert Smit, Hulshof, M.F., Wilde, J., de, Edwin CM Mariman, Smit Egbert, Mark V Boekschoten, de Wilde, J., Janneke de Wilde, Mariman Edwin CM, de Groot, P.J., de Wilde Janneke, de Groot Philip, Smit, E., Philip de Groot, Groot, P.J., de, Boekschoten Mark V, Martijn FM Hulshof, Hulshof Martijn FM, Hulshof, M.F.M., de Groot, P.   +21 more
core   +1 more source

Comparative analysis of the transcriptomes of EDL, psoas, and soleus muscles from mice

BMC Genomics, 2020
Background Individual skeletal muscles have evolved to perform specific tasks based on their molecular composition. In general, muscle fibers are characterized as either fast-twitch or slow-twitch based on their myosin heavy chain isoform profiles.
Pabodha Hettige, Uzma Tahir, Kiisa C. Nishikawa, Matthew J. Gage   +3 more
doaj   +1 more source

Peroxisome proliferator-activated receptor-γ coactivator-1α in muscle links metabolism to inflammation [PDF]

, 2009
1. In higher eukaryotes, metabolism and immunity are tightly coupled. However, whereas evolutionary, a compromised immune response due to undernourishment has been the predominant problem, the inflammatory response to obesity and other life style ...
Handschin, C., Handschin, C
core   +1 more source