Results 31 to 40 of about 1,504,818 (288)

Comparative analysis of the transcriptomes of EDL, psoas, and soleus muscles from mice

BMC Genomics, 2020
Background Individual skeletal muscles have evolved to perform specific tasks based on their molecular composition. In general, muscle fibers are characterized as either fast-twitch or slow-twitch based on their myosin heavy chain isoform profiles.
Pabodha Hettige, Uzma Tahir, Kiisa C. Nishikawa, Matthew J. Gage   +3 more
doaj   +1 more source

The embryonic genes Dkk3, Hoxd8, Hoxd9 and Tbx1 identify muscle types in a diet-independent and fiber-type unrelated way [PDF]

, 2010
Background The mouse skeletal muscle is composed of four distinct fiber types that differ in contractile function, number of mitochondria and metabolism. Every muscle type has a specific composition and distribution of the four fiber types. To find novel
Boekschoten, M.V., Mariman, E.C.M., Egbert Smit, Hulshof, M.F., Wilde, J., de, Edwin CM Mariman, Smit Egbert, Mark V Boekschoten, de Wilde, J., Janneke de Wilde, Mariman Edwin CM, de Groot, P.J., de Wilde Janneke, de Groot Philip, Smit, E., Philip de Groot, Groot, P.J., de, Boekschoten Mark V, Martijn FM Hulshof, Hulshof Martijn FM, Hulshof, M.F.M., de Groot, P.   +21 more
core   +1 more source

Cycling Cross-Bridges Contribute to Thin Filament Activation in Human Slow-Twitch Fibers

Frontiers in Physiology, 2020
It has been shown that not only calcium but also strong binding myosin heads contribute to thin filament activation in isometrically contracting animal fast-twitch and cardiac muscle preparations. This behavior has not been studied in human muscle fibers
Alfredo Jesus López-Dávila, Joseph M. Chalovich, Stefan Zittrich, Birgit Piep, Faramarz Matinmehr, Andras Málnási-Csizmadia, Anna Á. Rauscher, Theresia Kraft, Bernhard Brenner, Robert Stehle   +9 more
doaj   +1 more source

Light Chains from Slow‐Twitch Muscle Myosin. [PDF]

European Journal of Biochemistry, 1976
Myosin light chains have been isolated from slow‐twitch soleus muscles of rabbit and cat. Two chemically related light chains of molecular weight about 22000 have been identified from their thiol sequences in each species, and these have been further characterized by amino acid analysis and peptide mapping studies. These light chains are related to the
openaire   +2 more sources

Effect of ADP on slow‐twitch muscle fibres of the rat: implications for muscle fatigue [PDF]

The Journal of Physiology, 2006
Slow‐twitch mechanically skinned fibres from rat soleus muscle were bathed in solutions mimicking the myoplasmic environment but containing different [ADP] (0.1 μm to 1.0 mm). The effect of ADP on sarcoplasmic reticulum (SR) Ca2+‐content was determined from the magnitude of caffeine‐induced force responses, while temporal changes in SR Ca2+‐content ...
Macdonald, William Alexander., Stephenson, Dimitrie.   +1 more
openaire   +2 more sources

Peroxisome proliferator-activated receptor-γ coactivator-1α in muscle links metabolism to inflammation [PDF]

, 2009
1. In higher eukaryotes, metabolism and immunity are tightly coupled. However, whereas evolutionary, a compromised immune response due to undernourishment has been the predominant problem, the inflammatory response to obesity and other life style ...
Handschin, C., Handschin, C
core   +1 more source

Mitochondrial dynamics define muscle fiber type by modulating cellular metabolic pathways

Cell Reports, 2023
Summary: Skeletal muscle is highly developed after birth, consisting of glycolytic fast-twitch and oxidative slow-twitch fibers; however, the mechanisms of fiber-type-specific differentiation are poorly understood.
Tatsuki Yasuda, Takaya Ishihara, Ayaka Ichimura, Naotada Ishihara   +3 more
doaj   +1 more source

Diversity and Differential Expression of MicroRNAs in the Human Skeletal Muscle with Distinct Fiber Type Composition

Life, 2023
The ratio of fast- and slow-twitch fibers in human skeletal muscle is variable and largely determined by genetic factors. In this study, we investigated the contribution of microRNA (miRNA) in skeletal muscle fiber type composition.
Andrey V. Zhelankin, Liliia N. Iulmetova, Ildus I. Ahmetov, Eduard V. Generozov, Elena I. Sharova   +4 more
doaj   +1 more source

The slow sarco/endoplasmic reticulum Ca2+-ATPase declines independently of slow myosin in soleus muscle of diabetic rats [PDF]

, 2009
The sarcoplasmic reticulum Ca2+-ATPase (SERCA) isoforms are normally expressed in coordination with the corresponding myosin heavy chain (MyHC) isoforms in the fibers of skeletal muscle but this coordination is often disrupted in pathological conditions.
Rácz, Gábor, Zádor, Ernő, Vér, Ágota, Szabó, András   +3 more
core   +2 more sources

Quantitative analysis of dystrophin in fast‐ and slow‐twitch mammalian skeletal muscle [PDF]

FEBS Letters, 1992
The relative tissue content of dystrophin has been evaluated in the slow‐twitch soleus (primarily type I fibers) and fast‐twitch vastus lateralis (primarily type IIb filbers) muscles of the rat and mouse, as well as in human biopsy samples from the vastus lateralis and gluteus maximus muscles, using a sensitive immunochemical assay.
Ho-Kim, My-Anh, Rogers, Peter A.
openaire   +2 more sources