Results 91 to 100 of about 857,676 (288)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Topological properties of P.A. random graphs with edge-step functions
, 2019 In this work we investigate a preferential attachment model whose parameter is a function $f:\mathbb{N}\to[0,1]$ that drives the asymptotic proportion between the numbers of vertices and edges of the graph.
Alves, Caio +2 more
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Critical dynamics of ballistic and Brownian particles in a heterogeneous environment
, 2007 The dynamic properties of a classical tracer particle in a random, disordered medium are investigated close to the localization transition. For Lorentz models obeying Newtonian and diffusive motion at the microscale, we have performed large-scale ...
Boon J. P. +9 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
ON THE ALMOST PERIODIC AT INFINITY FUNCTIONS FROM HOMOGENEOUS SPACES
Проблемы анализа, 2018 We consider homogeneous spaces of functions defined on the real axis (or semi-axis) with values in a complex Banach space. We study the new class of almost periodic at infinity functions from homogeneous spaces.
Baskakov A. G. +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Sox2 Acts in a Dose-Dependent Fashion to Regulate Proliferation of Cortical Progenitors
Cell Reports, 2014 Summary: Organ formation and maintenance depends on slowly self-renewing stem cells that supply an intermediate population of rapidly dividing progenitors, but how this proliferative hierarchy is regulated is unknown.
Daniel W. Hagey, Jonas Muhr
doaj +1 more source
Capillary-gravity wave transport over spatially random drift [PDF]
, 1999 We derive transport equations for the propagation of water wave action in the presence of a static, spatially random surface drift. Using the Wigner distribution $\W(\x,\k,t)$ to represent the envelope of the wave amplitude at position $\x$ contained in ...
Bal, G, Chou, T
core +1 more source
Functional limit theorems for the Bouchaud trap model with slowly varying traps
Stochastic Processes and their Applications, 2015 We consider the Bouchaud trap model on the integers in the case that the trap distribution has a slowly varying tail at infinity. Our main result is a functional limit theorem for the model under the annealed law, analogous to the functional limit theorems previously established in the literature in the case of integrable or regularly varying trap ...
David Croydon, Stephen Muirhead
openaire +2 more sources