Results 71 to 80 of about 27,932 (217)

Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium

Cell Reports, 2019
Summary: DNA damage activates checkpoints that limit the replicative potential of stem cells, including differentiation. These checkpoints protect against cancer development but also promote tissue aging.
Kayla M. Gross, Wenhui Zhou, Jerrica L. Breindel, Jian Ouyang, Dexter X. Jin, Ethan S. Sokol, Piyush B. Gupta, Kathryn Huber, Lee Zou, Charlotte Kuperwasser   +9 more
doaj   +1 more source

Bamboo‐Like Whiskers‐Reinforced Bioceramics Accelerate Large Segmental Bone Regeneration via Dual Modulation of Type‐H Vessels and Osteoinduction

Advanced Science, EarlyView.
The graphical abstract image of bamboo‐like whisker‐reinforced Ca‐P bioceramics accelerating large segmental bone regeneration. ABSTRACT Regenerative repair of segmental bone defect remains a major clinical challenge. The conventional mental implants suffer from mechanical strength mismatch and long‐term foreign bodies presence.
Cong Feng, Haibo Teng, Chuyao Xu, Jiaze He, Keting Liu, Xueying Li, Kai Zhang, Xiangdong Zhu, Xiangfeng Li, Jianguo Xu, Xingdong Zhang   +10 more
wiley   +1 more source

An Embodied Paper‐Based Microfluidic Al‐Air Battery for Enduring Untethered Insect‐Scale Robots

Advanced Science, EarlyView.
This work presents a centimeter‐scale microfluidic aluminum–air battery (MFAAB) with dual‐surface anode and F−‐mediated byproduct decomposition. The design enables a high capacity of 2697.05 mAh/g Al and delivers tens of milliwatts to power LEDs, motors, and a toy car.
Yun Yang, Tao Jiang, Zhongyue Lu, Dapeng Fan, Zucheng Yi, Zirong Luo   +5 more
wiley   +1 more source

Translational Inhibition of Slug by Pdcd4 Contributes to Invasion Inhibition in Colorectal Cancer Cells

Cancer Medicine
Background Colorectal cancer (CRC) metastasis remains a major cause of mortality, driven by epithelial‐to‐mesenchymal transition (EMT) and invasion. Programmed cell death 4 (Pdcd4), a tumor suppressor, is known to inhibit translation via interaction with
Qing Wang, Wei He, Shilong Han, Maoquan Li, Yanlei Wang, Yekaterina Zaytseva, Li Chen, Jiang Zhu, Hsin‐Sheng Yang   +8 more
doaj   +1 more source

Continuous Generation of Millimeter-Sized Glycine Crystals in Non-Seeded Millifluidic Slug Flow

Crystals, 2019
Millimeter-sized α-glycine crystals were generated from continuous non-seeded cooling crystallization in slug flow. The crystallization process is composed of three steps in sequence: slug formation, crash-cooling nucleation, and growth.
Mingyao Mou, Huayu Li, Bing-Shiou Yang, Mo Jiang   +3 more
doaj   +1 more source

Dual‐Substrate Synergistic Photocatalysis: Exogenous Reagent‐Free Co‐Removal of Phenol and Cr(VI) via Electron‐Donor‐Mediated Redox Coupling over Modified Carbon Nitride

Advanced Science, EarlyView.
An exogenous reagent‐free dual‐substrate strategy harnesses phenol as an intrinsic electron donor to drive synchronous phenol degradation and Cr(VI) reduction over modified carbon nitride. π–π stacking and hydrogen bonding direct electron transfer to the catalyst, enriching photogenerated electrons and accelerating Cr(VI) reduction 6.4‐fold. This waste‐
Xiaoman Zhang, Qiyu Wang, Xiaodan Liu, Shuqi Wan, Cuiwei Du, Qilu Li, Chongfei Yu, Shuying Dong, Xianfa Su, Chun Hu   +9 more
wiley   +1 more source

Full‐Stack Architectures for Intelligent Brain‐Computer Interfaces

Advanced Science, EarlyView.
System‐level overview of brain–computer interfaces (BCIs), illustrating the integration of neural signal acquisition, wireless transmission, and adaptive decoding. Advanced electrode, tissue interfaces, energy‐efficient communication, and robust algorithms collectively enable stable signal quality, real‐time processing, and closed‐loop operation ...
Hee Kyu Lee, Hyun Bin Kim, Sang Uk Park, Janghoon Joo, Jinhong Min, Geumbee Lee, Joohoon Kang, Hyoyoung Jeong, Jae‐Young Yoo, Sang Min Won   +9 more
wiley   +1 more source

Imaging‐Guided Live Single‐Cell Lipid Profiling of Leader and Follower Cellsduring Collective Migration of Triple‐Negative Breast Cancer Cells

Advanced Science, EarlyView.
Integrated single‐cell mass spectrometry reveals distinct lipidomic signatures that differentiate leader and follower phenotypes in migratory breast cancer cells. Phenotype‐specific alterations across various lipid classes, including fatty acids and phosphatidylcholines, underpin functional heterogeneity.
Xiaoyue Huang, Judit González Riera, Mai Nguyen, Jeremy Broekhuis, Sylvia E. Le Dévédec, Ahmed Ali, Thomas Hankemeier   +6 more
wiley   +1 more source

CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN

Advanced Science, EarlyView.
ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu, Yifan Zhang, Haolin Li, Shengyu Zhao, Xiaoran Dai, Qili Xu, Mintian Fei, Chun Li, Zhihui Zou, Baojun Wang, Li Zhang, Hui Wang, Ligang Zhang, Chaozhao Liang   +13 more
wiley   +1 more source

AI‐Physics‐Experiment Trinity for Integrated Protein Dynamics Modeling

Advanced Science, EarlyView.
This review unites experiments, physics‐based simulations, and AI as a synergistic triad for protein dynamics modeling. It highlights integrative strategies, resolves sampling and forcefield bottlenecks, and outlines challenges and future directions for accurate, interpretable conformational ensemble prediction.
Chen Shi, Minying Low, Peng Xiu, Kresten Lindorff‐Larsen, Yong Wang   +4 more
wiley   +1 more source